2J0T
Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
E | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
F | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A1266 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A1267 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
D | CYS1 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA A1268 |
Chain | Residue |
A | GLY190 |
A | GLY192 |
A | ASP194 |
A | ASP158 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A1269 |
Chain | Residue |
A | ASP175 |
A | GLY176 |
A | GLY178 |
A | ASN180 |
A | ASP198 |
A | GLU201 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA A1270 |
Chain | Residue |
A | ASP124 |
A | GLU199 |
A | GLU201 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B1267 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B1268 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
E | CYS1 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA B1269 |
Chain | Residue |
B | ASP158 |
B | GLY190 |
B | GLY192 |
B | ASP194 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B1270 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ASN180 |
B | ASP198 |
B | GLU201 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B1271 |
Chain | Residue |
B | ASP124 |
B | GLU199 |
B | GLU201 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C1264 |
Chain | Residue |
C | HIS168 |
C | ASP170 |
C | HIS183 |
C | HIS196 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C1265 |
Chain | Residue |
C | HIS218 |
C | HIS222 |
C | HIS228 |
F | CYS1 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA C1266 |
Chain | Residue |
C | ASP158 |
C | GLY190 |
C | GLY192 |
C | ASP194 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C1267 |
Chain | Residue |
C | ASP175 |
C | GLY176 |
C | GLY178 |
C | ASN180 |
C | ASP198 |
C | GLU201 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA C1268 |
Chain | Residue |
C | ASP124 |
C | GLU199 |
C | GLU201 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
A | VAL215-LEU224 |
site_id | PS00288 |
Number of Residues | 13 |
Details | TIMP Tissue inhibitors of metalloproteinases signature. CtCvPpHPQtaFC |
Chain | Residue | Details |
D | CYS1-CYS13 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22427646 |
Chain | Residue | Details |
D | CYS1 | |
E | CYS1 | |
F | CYS1 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | SITE: Involved in metalloproteinase-binding => ECO:0000269|PubMed:22427646, ECO:0007744|PDB:3V96 |
Chain | Residue | Details |
D | LEU34 | |
E | LEU34 | |
F | LEU34 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19139490 |
Chain | Residue | Details |
D | ASN30 | |
E | ASN30 | |
F | ASN30 | |
B | ASP158 | |
B | GLY190 | |
B | ASP194 | |
C | ASP158 | |
C | GLY190 | |
C | ASP194 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002 |
Chain | Residue | Details |
D | ASN78 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
C | HIS168 | |
C | HIS183 | |
C | HIS196 | |
C | HIS218 | |
C | HIS222 | |
C | HIS228 | |
E | ASN78 | |
F | ASN78 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
B | HIS168 | |
B | HIS183 | |
B | HIS196 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP170 | |
B | ASP170 | |
C | ASP170 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP175 | |
B | ASP175 | |
C | ASP175 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY176 | |
B | GLY176 | |
C | GLY176 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY178 | |
A | ASN180 | |
B | GLY178 | |
B | ASN180 | |
C | GLY178 | |
C | ASN180 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY192 | |
B | GLY192 | |
C | GLY192 |
site_id | SWS_FT_FI10 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP198 | |
B | ASP198 | |
C | ASP198 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU199 | |
B | GLU199 | |
C | GLU199 |
site_id | SWS_FT_FI12 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU201 | |
B | GLU201 | |
C | GLU201 |
site_id | SWS_FT_FI13 |
Number of Residues | 3 |
Details | SITE: Not glycosylated => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN143 | |
B | ASN143 | |
C | ASN143 |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:2557822 |
Chain | Residue | Details |
A | PRO269 | |
B | PRO269 | |
C | PRO269 |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN120 | |
B | ASN120 | |
C | ASN120 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET236 | |
A | GLU219 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | MET236 | |
B | GLU219 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | MET236 | |
C | GLU219 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU219 |
site_id | CSA5 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU219 |
site_id | CSA6 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | GLU219 |