2J0T
Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | INTERSTITIAL COLLAGENASE | polymer | 170 | 18996.7 | 3 | UniProt (P03956) Pfam (PF00413) In PDB | HOMO SAPIENS (HUMAN) | MATRIX METALLOPROTEINASE-1, MMP-1, FIBROBLAST COLLAGENASE |
| 2 | D, E, F | METALLOPROTEINASE INHIBITOR 1 | polymer | 126 | 14269.3 | 3 | UniProt (P01033) Pfam (PF00965) In PDB | HOMO SAPIENS (HUMAN) | TIMP-1, ERYTHROID POTENTIATING ACTIVITY, EPA, TISSUE INHIBITOR OF METALLOPROTEINASES, FIBROBLAST COLLAGENASE INHIBITOR, COLLAGENASE INHIBITOR, TISSUE INHIBITOR OF METALLOPROTEINASE-1 |
| 3 | A, B, C | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | A, B, C | CALCIUM ION | non-polymer | 40.1 | 9 | Chemie (CA) | |||
| 5 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B, C: 101 - 269 (UniProt: P03956)
| PDB | External Database | Details |
|---|---|---|
| Met 100 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 99798.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 753.2 | |
| All* | Total formula weight | 100551.3 |
