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coronavirus
Coronavirus, 2020. Modified from the original illustration by David S. Goodsell@RCSB PDB

The recent outbreak of the Novel Coronavirus disease (COVID-19) is a serious threat to people all over the world. In order to understand and develop an effective drug against this virus (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2), structural work on the related proteins has already started and the resultant entries are accumulating in the PDB. PDBj provides a portal page for the COVID-19 related entries for our users. New entries will be added simultaneously with the public release from the wwPDB.

An explanation article covering one of the proteins of this virus is available on the "Molecules of the Month" page below:

The tab "All entries" contains all PDB IDs, in case you want to check all independent entries, including group depositions by the same authors. The "Repr. entries" tab contains only representative PDB entries with the highest resolution, excluding duplicate entries with 100% amino acid sequence identitiy, even if they contain a different ligand. Finally, the "Latest entries" tab contains the latest entries released this week.


Created: 2020-10-28 (last edited: more than 1 year ago)2022-09-02
8VKM
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Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
Deposit date:2024-01-09
Release date:2024-02-14
Last modified:2025-02-26
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024
8VKN
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BU of 8vkn by Molmil
Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (focused refinement of RBD and mouse ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
Deposit date:2024-01-09
Release date:2024-02-14
Last modified:2025-02-26
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024
8VKO
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BU of 8vko by Molmil
Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
Deposit date:2024-01-09
Release date:2024-02-14
Last modified:2025-02-26
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024
8VKP
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BU of 8vkp by Molmil
Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
Deposit date:2024-01-09
Release date:2024-02-14
Last modified:2025-02-26
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024
8CDC
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BU of 8cdc by Molmil
Native 3CLpro from SARS-CoV-2 at 1.54 A
Descriptor: 3C-like proteinase
Authors:Mazzei, L, Jovanovic, A, Acton, T.B, Ciurli, S, Montelione, G.T.
Deposit date:2023-01-30
Release date:2024-02-21
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Expression, purification, and characterization of SARS-CoV2 3CLpro in a mature form
To Be Published
8CIN
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BU of 8cin by Molmil
BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA.4/5-5 fab HEAVY CHAIN, ...
Authors:Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E.
Deposit date:2023-02-10
Release date:2024-02-21
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86.
Nat Commun, 15, 2024
8G70
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BU of 8g70 by Molmil
SARS-CoV-2 spike/nanobody mixture complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, ...
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:SARS-CoV-2 spike/nanobody mixture complex
To Be Published
8G71
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BU of 8g71 by Molmil
Spike/Nb2 complex with 1 RBD up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:SARS-CoV-2 spike/Nb2 complex with 1 RBD up
To Be Published
8G76
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BU of 8g76 by Molmil
SARS-CoV-2 spike/Nb5 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-5, ...
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants.
Plos Pathog., 20, 2024
8G77
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BU of 8g77 by Molmil
SARS-CoV-2 spike/Nb6 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-6, ...
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants.
Plos Pathog., 20, 2024
8G78
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BU of 8g78 by Molmil
Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-5, Nanosota-6, ...
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD
To Be Published
8G79
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BU of 8g79 by Molmil
Local refinement of SARS-CoV-2 spike/nanobody mixture complex around RBD
Descriptor: Nanosota-3, Nanosota-4, Spike glycoprotein
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Local refinement of SARS-CoV-2 spike/nanobody mixture complex around RBD
To Be Published
8G7A
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BU of 8g7a by Molmil
SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, Spike glycoprotein
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 (local refinement)
To Be Published
8G7B
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BU of 8g7b by Molmil
SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, Spike glycoprotein
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3
To Be Published
8G7C
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BU of 8g7c by Molmil
local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-4, Spike glycoprotein
Authors:Ye, G, Bu, F, Liu, B, Li, F.
Deposit date:2023-02-16
Release date:2024-02-21
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound
To Be Published
8RZC
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BU of 8rzc by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 11
Descriptor: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-imidazol-1-yl-benzoic acid, ...
Authors:Kalnins, G.
Deposit date:2024-02-12
Release date:2024-02-21
Last modified:2025-01-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RZD
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BU of 8rzd by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 9
Descriptor: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-(3-hydroxyphenyl)benzoic acid, ...
Authors:Kalnins, G.
Deposit date:2024-02-12
Release date:2024-02-21
Last modified:2025-01-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RZE
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BU of 8rze by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 10
Descriptor: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-pyridin-3-yl-benzoic acid, ...
Authors:Kalnins, G.
Deposit date:2024-02-12
Release date:2024-02-21
Last modified:2025-01-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8CMA
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BU of 8cma by Molmil
SARS-CoV-2 Delta-RBD complexed with BA.4/5-35 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BA.4/5-35 heavy chain, BA.4/5-35 light chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.I.
Deposit date:2023-02-18
Release date:2024-02-28
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Nat Commun, 15, 2024
8GWK
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BU of 8gwk by Molmil
SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP
Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y.
Deposit date:2022-09-17
Release date:2024-02-28
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
8GWM
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BU of 8gwm by Molmil
SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP
Descriptor: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), Helicase, Non-structural protein 7, ...
Authors:Yan, L.M, Rao, Z.H, Lou, Z.Y.
Deposit date:2022-09-17
Release date:2024-02-28
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
8WGV
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BU of 8wgv by Molmil
BA.2(S375) Spike (S6P)/hACE2 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Wei, X, Zhang, Z.
Deposit date:2023-09-22
Release date:2024-02-28
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
Nat.Immunol., 25, 2024
8WGW
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BU of 8wgw by Molmil
Local refinement of RBD-ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Wei, X, Zhang, Z.
Deposit date:2023-09-22
Release date:2024-02-28
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
Nat.Immunol., 25, 2024
8YA5
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BU of 8ya5 by Molmil
Mpro from SARS-CoV-2
Descriptor: 3C-like proteinase
Authors:Zhang, C.Y, Xu, Q, Wang, W.W, Zhou, H, Wang, Q.S.
Deposit date:2024-02-07
Release date:2024-02-28
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystallographic data collection using a multilayer monochromator on an undulator beamline at SSRF
To Be Published
8IG4
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BU of 8ig4 by Molmil
Crystal structure of SARS-Cov-2 main protease in complex with GC376
Descriptor: Non-structural protein 11, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide
Authors:Zhou, X.L, Zhang, J, Li, J.
Deposit date:2023-02-20
Release date:2024-03-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376.
J.Mol.Biol., 436, 2024

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