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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-03-11 (last edited: yesterday)2020-08-13
所有结构 (325)代表性结构 (124)最新条目 (8)
6XLU
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STRUCTURE OF SARS-COV-2 SPIKE AT PH 4.0
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhou, T., Tsybovsky, Y., Olia, A., Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Biorxiv, 2020
7CAH
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THE INTERFACE OF H014 FAB BINDS TO SARS-COV-2 S
Descriptor:Light chain of H014 Fab, Heavy chain of H014 Fab, Spike glycoprotein
Authors:Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Rao, Z., wang, Y., Qin, C., Wang, X.
Deposit date:2020-06-08
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
Science, 2020
6XM3
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STRUCTURE OF SARS-COV-2 SPIKE AT PH 5.5, SINGLE RBD UP, CONFORMATION 1
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhou, T., Tsybovsky, Y., Olia, A., Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Biorxiv, 2020
6XM0
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CONSENSUS STRUCTURE OF SARS-COV-2 SPIKE AT PH 5.5
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhou, T., Tsybovsky, Y., Olia, A., Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Biorxiv, 2020
6ZRU
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CRYSTAL STRUCTURE OF SARS COV2 MAIN PROTEASE IN COMPLEX WITH INHIBITOR BOCEPREVIR
Descriptor:Main Protease, DIMETHYL SULFOXIDE, boceprevir (bound form)
Authors:Oerlemans, R., Wang, W., Lunev, S., Domling, A., Groves, M.R.
Deposit date:2020-07-14
Release date:2020-08-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of SARS CoV2 main protease in complex with inhibitor Boceprevir
To Be Published
7JN2
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER441
Descriptor:Papain-Like Protease, 3-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-08-03
Release date:2020-08-12
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder441
to be published
6XM4
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STRUCTURE OF SARS-COV-2 SPIKE AT PH 5.5, SINGLE RBD UP, CONFORMATION 2
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhou, T., Tsybovsky, Y., Olia, A., Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Biorxiv, 2020
6ZRT
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CRYSTAL STRUCTURE OF SARS COV2 MAIN PROTEASE IN COMPLEX WITH INHIBITOR TELAPREVIR
Descriptor:Main Protease, DIMETHYL SULFOXIDE, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide
Authors:Oerlemans, R., Wang, W., Lunev, S., Domling, A., Groves, M.R.
Deposit date:2020-07-14
Release date:2020-08-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of SARS CoV2 main protease in complex with inhibitor Telaprevir
To Be Published
7JIT
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER495
Descriptor:Papain-like protease, 5-[(carbamoylcarbamoyl)amino]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder495
to be published
7JIW
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER530
Descriptor:Papain-Like Protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder530
to be published
7JIV
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER530
Descriptor:Papain-like protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder530
to be published
7JIR
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER457
Descriptor:Papain-like protease, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder457
to be published
6WC1
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PEPTIDE-BOUND SARS-COV-2 NSP9 RNA-REPLICASE
Descriptor:SARS-coV-2 Non-structural protein 9, SULFATE ION
Authors:Littler, D.R., Gully, B.S., Rossjohn, J.
Deposit date:2020-03-28
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of a putative peptide-binding site at the dimer interface of the SARS-CoV-2 Nsp9 RNA-replicase.
To Be Published
6ZLW
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SARS-COV-2 NSP1 BOUND TO THE HUMAN 40S RIBOSOMAL SUBUNIT
Descriptor:40S ribosomal protein SA, 40S ribosomal protein S3a, 40S ribosomal protein S2, ...
Authors:Thoms, M., Buschauer, R., Ameismeier, M., Denk, T., Kratzat, H., Mackens-Kiani, T., Cheng, J., Berninghausen, O., Becker, T., Beckmann, R.
Deposit date:2020-07-01
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 2020
6ZP7
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SARS-COV-2 SPIKE IN PREFUSION STATE (FLEXIBILITY ANALYSIS, 1-UP OPEN CONFORMATION)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Martinez, M., Marabini, R., Carazo, J.M.
Deposit date:2020-07-08
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
Biorxiv, 2020
6ZON
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SARS-COV-2 NSP1 BOUND TO A HUMAN 43S PREINITIATION RIBOSOME COMPLEX - STATE 1
Descriptor:40S ribosomal protein SA, 40S ribosomal protein S3a, 40S ribosomal protein S2, ...
Authors:Thoms, M., Buschauer, R., Ameismeier, M., Denk, T., Kratzat, H., Mackens-Kiani, T., Cheng, J., Berninghausen, O., Becker, T., Beckmann, R.
Deposit date:2020-07-07
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 2020
6ZSL
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CRYSTAL STRUCTURE OF THE SARS-COV-2 HELICASE AT 1.94 ANGSTROM RESOLUTION
Descriptor:SARS-CoV-2 helicase NSP13, ZINC ION, PHOSPHATE ION
Authors:Newman, J.A., Yosaatmadja, Y., Douangamath, A., Arrowsmith, C.H., von Delft, F., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-07-15
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
To Be Published
6ZOW
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SARS-COV-2 SPIKE IN PREFUSION STATE
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Martinez, M., Marabini, R., Carazo, J.M.
Deposit date:2020-07-07
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
Biorxiv, 2020
7C7P
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CRYSTAL STRUCTURE OF THE SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH TELAPREVIR
Descriptor:main protease, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, CHLORIDE ION, ...
Authors:Zeng, R., Qiao, J.X., Wang, Y.F., Li, Y.S., Yao, R., Yang, S.Y., Lei, J.
Deposit date:2020-05-26
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir
To Be Published
7JFQ
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH DE-OXIDIZED C145
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-17
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
To Be Published
6XM5
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STRUCTURE OF SARS-COV-2 SPIKE AT PH 5.5, ALL RBDS DOWN
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhou, T., Tsybovsky, Y., Olia, A., Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-07-29
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Biorxiv, 2020
6XQB
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SARS-COV-2 RDRP/RNA COMPLEX
Descriptor:RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ...
Authors:Liu, B., Shi, W., Yang, Y.
Deposit date:2020-07-09
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
6ZDG
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ASSOCIATION OF THREE COMPLEXES OF LARGELY STRUCTURALLY DISORDERED SPIKE ECTODOMAIN WITH BOUND EY6A FAB
Descriptor:Spike glycoprotein, EY6A heavy chain, EY6A light chain, ...
Authors:Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I.
Deposit date:2020-06-14
Release date:2020-07-29
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 2020
6XEZ
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STRUCTURE OF SARS-COV-2 REPLICATION-TRANSCRIPTION COMPLEX BOUND TO NSP13 HELICASE - NSP13(2)-RTC
Descriptor:nsp12, nsp8, nsp7, ...
Authors:Chen, J., Malone, B., Llewellyn, E.C., Campbell, E.A., Darst, S.A.
Deposit date:2020-06-14
Release date:2020-07-29
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.
Biorxiv, 2020
6ZBP
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H11-H4 COMPLEX WITH SARS-COV-2
Descriptor:Spike glycoprotein, H11-H4, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Naismith, J.H., Huo, J., Mikolajek, H., Ward, P., Dumoux, M., Owens, R.J., LeBas, A.
Deposit date:2020-06-08
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:H11-D4 complex with SARS-CoV-2 RBD
To Be Published
167518
数据于2020-08-12公开中