7LRT
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7N8H
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7N8I
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7BWQ
| Structure of nonstructural protein Nsp9 from SARS-CoV-2 | 分子名称: | Nsp9, SULFATE ION | 著者 | Zhang, C, Chen, Y, Li, L, Su, D. | 登録日 | 2020-04-15 | 公開日 | 2021-07-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.954 Å) | 主引用文献 | Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed, 1, 2020
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7EGQ
| Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | 著者 | Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2021-03-25 | 公開日 | 2021-07-21 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
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7KRI
| FR6-bound SARS-CoV-2 Nsp9 RNA-replicase | 分子名称: | 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ... | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | 登録日 | 2020-11-20 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9. J.Biol.Chem., 297, 2021
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7R6W
| SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Snell, G, Czudnochowski, N, Hernandez, P, Nix, J.C, Croll, T.I, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | 登録日 | 2021-06-23 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature, 597, 2021
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7R6X
| SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Monoclonal antibody S2E12 Fab heavy chain, ... | 著者 | Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | 登録日 | 2021-06-23 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature, 597, 2021
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7R7N
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7M42
| Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989 | 分子名称: | REGN10985 antibody Fab fragment heavy chain, REGN10985 antibody Fab fragment light chain, REGN10989 antibody Fab fragment heavy chain, ... | 著者 | Zhou, Y, Romero Hernandez, A, Saotome, K, Franklin, M.C. | 登録日 | 2021-03-19 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies. Cell, 184, 2021
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7MLZ
| Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain | 分子名称: | B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike protein S1, ... | 著者 | Zhou, T, Tsybovsky, T, Kwong, P.D. | 登録日 | 2021-04-29 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Science, 373, 2021
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7MM0
| Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B1-182.1 Fab heavy chain, ... | 著者 | Zhou, T, Tsybovsky, T, Kwong, P.D. | 登録日 | 2021-04-29 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Science, 373, 2021
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7N0B
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7N0C
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7N0D
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7N1A
| SARS-CoV-2 YLQ peptide binds to HLA-A2 | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1B
| SARS-CoV-2 RLQ peptide binds to HLA-A2 | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1E
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7N1F
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7N6D
| HLA peptide complex | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... | 著者 | Chaurasia, P, Petersen, J, Rossjohn, J. | 登録日 | 2021-06-08 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein. J.Biol.Chem., 297, 2021
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7N6E
| TCR peptide HLA-A2 complex | 分子名称: | Beta-2-microglobulin, MHC class I antigen, Spike protein S1, ... | 著者 | Chaurasia, P, Rossjohn, J, Petersen, J. | 登録日 | 2021-06-08 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein. J.Biol.Chem., 297, 2021
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7P3D
| MHC I A02 Allele presenting YLQPRTFLL | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... | 著者 | Rizkallah, P.J, Sewell, A.K, Wall, A, Fuller, A. | 登録日 | 2021-07-07 | 公開日 | 2021-07-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell, 185, 2022
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7F62
| Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody chAb-25 (Focused refinement of S-RBD and chAb-25 region) | 分子名称: | RBD-chAb-25, Heavy chain, Light chain, ... | 著者 | Yang, T.J, Yu, P.Y, Wu, H.C, Hsu, S.T.D. | 登録日 | 2021-06-24 | 公開日 | 2021-08-04 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure-guided antibody cocktail for prevention and treatment of COVID-19. Plos Pathog., 17, 2021
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7KM5
| Crystal structure of SARS-CoV-2 RBD complexed with Nanosota-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Spike protein S1, ... | 著者 | Ye, G, Shi, K, Aihara, H, Li, F. | 登録日 | 2020-11-02 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | The development of Nanosota - 1 as anti-SARS-CoV-2 nanobody drug candidates. Elife, 10, 2021
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7N3I
| Crystal structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment C098 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C098 Fab heavy chain, C098 Fab light chain, ... | 著者 | Flyak, A.I, Bjorkman, P.J, Barnes, C.O. | 登録日 | 2021-06-01 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity, 54, 2021
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