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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
7EGQ
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BU of 7egq by Molmil
Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading
分子名称: Helicase, MAGNESIUM ION, Non-structural protein 10, ...
著者Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y.
登録日2021-03-25
公開日2021-07-21
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading.
Cell, 184, 2021
7KRI
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BU of 7kri by Molmil
FR6-bound SARS-CoV-2 Nsp9 RNA-replicase
分子名称: 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ...
著者Littler, D.R, Gully, B.S, Rossjohn, J.
登録日2020-11-20
公開日2021-07-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9.
J.Biol.Chem., 297, 2021
7R6W
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BU of 7r6w by Molmil
SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
著者Snell, G, Czudnochowski, N, Hernandez, P, Nix, J.C, Croll, T.I, Corti, D, Cameroni, E, Pinto, D, Beltramello, M.
登録日2021-06-23
公開日2021-07-21
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Nature, 597, 2021
7R6X
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SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Monoclonal antibody S2E12 Fab heavy chain, ...
著者Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M.
登録日2021-06-23
公開日2021-07-21
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Nature, 597, 2021
7R7N
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BU of 7r7n by Molmil
SARS-CoV-2 spike in complex with the S2D106 neutralizing antibody Fab fragment (local refinement of the RBD and S2D106)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S2D106 FAB heavy chain, S2D106 FAB light chain, ...
著者Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2021-06-25
公開日2021-07-21
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.95 Å)
主引用文献SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Nature, 597, 2021
7M42
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BU of 7m42 by Molmil
Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989
分子名称: REGN10985 antibody Fab fragment heavy chain, REGN10985 antibody Fab fragment light chain, REGN10989 antibody Fab fragment heavy chain, ...
著者Zhou, Y, Romero Hernandez, A, Saotome, K, Franklin, M.C.
登録日2021-03-19
公開日2021-07-28
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Cell, 184, 2021
7MLZ
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Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain
分子名称: B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike protein S1, ...
著者Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日2021-04-29
公開日2021-07-28
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
7MM0
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BU of 7mm0 by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B1-182.1 Fab heavy chain, ...
著者Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日2021-04-29
公開日2021-07-28
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
7N0B
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BU of 7n0b by Molmil
Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (WT)-RNA complex
分子名称: CALCIUM ION, Non-structural protein 10, Proofreading exoribonuclease, ...
著者Liu, C, Yang, Y.
登録日2021-05-25
公開日2021-07-28
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
Science, 373, 2021
7N0C
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BU of 7n0c by Molmil
Cryo-EM structure of the monomeric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex
分子名称: MAGNESIUM ION, Non-structural protein 10, Proofreading exoribonuclease, ...
著者Liu, C, Yang, Y.
登録日2021-05-25
公開日2021-07-28
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
Science, 373, 2021
7N0D
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BU of 7n0d by Molmil
Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex
分子名称: CHAPSO, MAGNESIUM ION, Non-structural protein 10, ...
著者Liu, C, Yang, Y.
登録日2021-05-25
公開日2021-07-28
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
Science, 373, 2021
7N1A
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BU of 7n1a by Molmil
SARS-CoV-2 YLQ peptide binds to HLA-A2
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Wu, D, Mariuzza, R.A.
登録日2021-05-27
公開日2021-07-28
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.065 Å)
主引用文献Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
7N1B
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BU of 7n1b by Molmil
SARS-CoV-2 RLQ peptide binds to HLA-A2
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Wu, D, Mariuzza, R.A.
登録日2021-05-27
公開日2021-07-28
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
7N1E
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BU of 7n1e by Molmil
SARS-CoV-2 RLQ peptide-specific TCR pRLQ3 binds to RLQ-HLA-A2
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Wu, D, Mariuzza, R.A.
登録日2021-05-27
公開日2021-07-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
7N1F
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BU of 7n1f by Molmil
SARS-CoV-2 YLQ peptide-specific TCR pYLQ7 binds to YLQ-HLA-A2
分子名称: Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ...
著者Wu, D, Mariuzza, R.A.
登録日2021-05-27
公開日2021-07-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.393 Å)
主引用文献Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
7N6D
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BU of 7n6d by Molmil
HLA peptide complex
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ...
著者Chaurasia, P, Petersen, J, Rossjohn, J.
登録日2021-06-08
公開日2021-07-28
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
J.Biol.Chem., 297, 2021
7N6E
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BU of 7n6e by Molmil
TCR peptide HLA-A2 complex
分子名称: Beta-2-microglobulin, MHC class I antigen, Spike protein S1, ...
著者Chaurasia, P, Rossjohn, J, Petersen, J.
登録日2021-06-08
公開日2021-07-28
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
J.Biol.Chem., 297, 2021
7P3D
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BU of 7p3d by Molmil
MHC I A02 Allele presenting YLQPRTFLL
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Sewell, A.K, Wall, A, Fuller, A.
登録日2021-07-07
公開日2021-07-28
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope.
Cell, 185, 2022
7KM5
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BU of 7km5 by Molmil
Crystal structure of SARS-CoV-2 RBD complexed with Nanosota-1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Spike protein S1, ...
著者Ye, G, Shi, K, Aihara, H, Li, F.
登録日2020-11-02
公開日2021-08-04
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献The development of Nanosota - 1 as anti-SARS-CoV-2 nanobody drug candidates.
Elife, 10, 2021
7N3I
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BU of 7n3i by Molmil
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment C098
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C098 Fab heavy chain, C098 Fab light chain, ...
著者Flyak, A.I, Bjorkman, P.J, Barnes, C.O.
登録日2021-06-01
公開日2021-08-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Immunity, 54, 2021
7N62
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BU of 7n62 by Molmil
SARS-CoV-2 Spike (2P) in complex with C12C9 Fab (NTD local reconstruction)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C12C9 Fab heavy chain, C12C9 Fab light chain, ...
著者Windsor, I.W, Jenni, S, Bajic, G, Tong, P, Gautam, A.K, Wesemann, D.R, Harrison, S.C.
登録日2021-06-07
公開日2021-08-04
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Biorxiv, 2021
7N64
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BU of 7n64 by Molmil
SARS-CoV-2 Spike (2P) in complex with G32R7 Fab (RBD and NTD local reconstruction)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, G32R7 Fab heavy chain, ...
著者Windsor, I.W, Jenni, S, Tong, P, Gautam, A.K, Wesemann, D.R, Harrison, S.C.
登録日2021-06-07
公開日2021-08-04
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Biorxiv, 2021
7N9A
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BU of 7n9a by Molmil
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS RBD with NB21
分子名称: Nanobody Nb21, Spike protein S1
著者Sun, D, Zhang, C, Shi, Y.
登録日2021-06-17
公開日2021-08-04
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes
To Be Published
7N9B
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BU of 7n9b by Molmil
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB21
分子名称: NB21 Nanobody, Spike glycoprotein
著者Sun, D, Zhang, C, Shi, Y.
登録日2021-06-17
公開日2021-08-04
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7N9C
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Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95
分子名称: Nanobody NB95, Spike glycoprotein
著者Sun, D, Zhang, C, Shi, Y.
登録日2021-06-17
公開日2021-08-04
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021

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件を2025-07-09に公開中

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