7M42

Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989

Summary for 7M42

• Entry DOI: 10.2210/pdb7m42/pdb
• EMDB information: 23662
• Descriptor: REGN10989 antibody Fab fragment light chain, REGN10989 antibody Fab fragment heavy chain, Spike protein S1, ... (6 entities in total)
• Functional Keywords: sars-cov-2, rbd, neutralizing antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 124303.24

Authors

Zhou, Y.,Romero Hernandez, A.,Saotome, K.,Franklin, M.C. (deposition date: 2021-03-19, release date: 2021-07-28, Last modification date: 2021-08-25)

• Primary citation: Copin, R.,Baum, A.,Wloga, E.,Pascal, K.E.,Giordano, S.,Fulton, B.O.,Zhou, A.,Negron, N.,Lanza, K.,Chan, N.,Coppola, A.,Chiu, J.,Ni, M.,Wei, Y.,Atwal, G.S.,Hernandez, A.R.,Saotome, K.,Zhou, Y.,Franklin, M.C.,Hooper, A.T.,McCarthy, S.,Hamon, S.,Hamilton, J.D.,Staples, H.M.,Alfson, K.,Carrion Jr., R.,Ali, S.,Norton, T.,Somersan-Karakaya, S.,Sivapalasingam, S.,Herman, G.A.,Weinreich, D.M.,Lipsich, L.,Stahl, N.,Murphy, A.J.,Yancopoulos, G.D.,Kyratsous, C.A.; The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.; Cell, 184:3949-, 2021; PubMed: 34161776; DOI: 10.1016/j.cell.2021.06.002

Experimental method

ELECTRON MICROSCOPY (3.3 Å)