7R7N

SARS-CoV-2 spike in complex with the S2D106 neutralizing antibody Fab fragment (local refinement of the RBD and S2D106)

Summary for 7R7N

• Entry DOI: 10.2210/pdb7r7n/pdb
• EMDB information: 24299
• Descriptor: S2D106 FAB heavy chain, Spike glycoprotein, S2D106 FAB light chain, ... (4 entities in total)
• Functional Keywords: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 167988.71

Authors

Park, Y.J.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-06-25, release date: 2021-07-21, Last modification date: 2021-09-15)

• Primary citation: Starr, T.N.,Czudnochowski, N.,Liu, Z.,Zatta, F.,Park, Y.J.,Addetia, A.,Pinto, D.,Beltramello, M.,Hernandez, P.,Greaney, A.J.,Marzi, R.,Glass, W.G.,Zhang, I.,Dingens, A.S.,Bowen, J.E.,Tortorici, M.A.,Walls, A.C.,Wojcechowskyj, J.A.,De Marco, A.,Rosen, L.E.,Zhou, J.,Montiel-Ruiz, M.,Kaiser, H.,Dillen, J.R.,Tucker, H.,Bassi, J.,Silacci-Fregni, C.,Housley, M.P.,di Iulio, J.,Lombardo, G.,Agostini, M.,Sprugasci, N.,Culap, K.,Jaconi, S.,Meury, M.,Dellota Jr., E.,Abdelnabi, R.,Foo, S.C.,Cameroni, E.,Stumpf, S.,Croll, T.I.,Nix, J.C.,Havenar-Daughton, C.,Piccoli, L.,Benigni, F.,Neyts, J.,Telenti, A.,Lempp, F.A.,Pizzuto, M.S.,Chodera, J.D.,Hebner, C.M.,Virgin, H.W.,Whelan, S.P.J.,Veesler, D.,Corti, D.,Bloom, J.D.,Snell, G.; SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.; Nature, 597:97-102, 2021; PubMed: 34261126; DOI: 10.1038/s41586-021-03807-6

Experimental method

ELECTRON MICROSCOPY (3.95 Å)