Entry | Database: PDB / ID: 4b1z |
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Title | Structure of the Phactr1 RPEL domain bound to G-actin |
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Components | - ACTIN, ALPHA SKELETAL MUSCLE
- PHOSPHATASE AND ACTIN REGULATOR 1
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Keywords | STRUCTURAL PROTEIN / NUCLEOTIDE-BINDING / TRANSCRIPTION REGULATION / TRANSCRIPTION / MUSCLE PROTEIN / ATP-BINDING / CYTOSKELETON |
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Function / homology | Function and homology information
dendrite arborization / regulation of neuron migration / protein phosphatase 1 binding / regulation of phosphorylation / actomyosin structure organization / protein phosphatase inhibitor activity / cytoskeletal motor activator activity / tropomyosin binding / stress fiber assembly / mesenchyme migration ...dendrite arborization / regulation of neuron migration / protein phosphatase 1 binding / regulation of phosphorylation / actomyosin structure organization / protein phosphatase inhibitor activity / cytoskeletal motor activator activity / tropomyosin binding / stress fiber assembly / mesenchyme migration / troponin I binding / myosin heavy chain binding / filamentous actin / actin filament bundle / skeletal muscle thin filament assembly / striated muscle thin filament / actin filament bundle assembly / skeletal muscle myofibril / actin monomer binding / skeletal muscle fiber development / stress fiber / titin binding / actin filament polymerization / filopodium / actin filament / cell motility / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / cerebral cortex development / calcium-dependent protein binding / lamellipodium / actin binding / cell body / actin cytoskeleton organization / hydrolase activity / protein domain specific binding / synapse / calcium ion binding / positive regulation of gene expression / magnesium ion binding / ATP binding / identical protein binding / nucleus / cytoplasm / cytosolSimilarity search - Function Helix Hairpins - #1750 / Helix Hairpins - #2130 / RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / Helix Hairpins / ATPase, nucleotide binding domain ...Helix Hairpins - #1750 / Helix Hairpins - #2130 / RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / Helix Hairpins / ATPase, nucleotide binding domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / Helix non-globular / Special / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology ADENOSINE-5'-TRIPHOSPHATE / Phosphatase and actin regulator 1 / Actin, alpha skeletal muscle / Phosphatase and actin regulator 1Similarity search - Component |
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Biological species | MUS MUSCULUS (house mouse) ORYCTOLAGUS CUNICULUS (rabbit) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.3 Å |
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Authors | Mouilleron, S. / Wiezlak, M. / O'Reilly, N. / Treisman, R. / McDonald, N.Q. |
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Citation | Journal: Structure / Year: 2012 Title: Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Authors: Mouilleron, S. / Wiezlak, M. / O'Reilly, N. / Treisman, R. / McDonald, N.Q. |
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History | Deposition | Jul 12, 2012 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 7, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 21, 2012 | Group: Database references |
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Revision 1.2 | Feb 28, 2018 | Group: Database references / Category: citation / citation_author Item: _citation.journal_id_ISSN / _citation.page_last ..._citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name |
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Revision 1.3 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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