Entry | Database: PDB / ID: 2yje |
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Title | Oligomeric assembly of actin bound to MRTF-A |
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Components | - ACTIN, ALPHA SKELETAL MUSCLE
- MKL/MYOCARDIN-LIKE PROTEIN 1
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Keywords | MOTOR PROTEIN |
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Function / homology | Function and homology information
SUMOylation of transcription cofactors / RHO GTPases Activate Formins / smooth muscle cell differentiation / cytoskeletal motor activator activity / tropomyosin binding / mesenchyme migration / troponin I binding / myosin heavy chain binding / filamentous actin / actin filament bundle ...SUMOylation of transcription cofactors / RHO GTPases Activate Formins / smooth muscle cell differentiation / cytoskeletal motor activator activity / tropomyosin binding / mesenchyme migration / troponin I binding / myosin heavy chain binding / filamentous actin / actin filament bundle / skeletal muscle thin filament assembly / striated muscle thin filament / actin filament bundle assembly / negative regulation of apoptotic signaling pathway / skeletal muscle myofibril / actin monomer binding / skeletal muscle fiber development / stress fiber / titin binding / forebrain development / actin filament polymerization / filopodium / actin filament / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / neuron migration / calcium-dependent protein binding / neuron projection development / lamellipodium / actin binding / cell body / actin cytoskeleton organization / molecular adaptor activity / transcription coactivator activity / hydrolase activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity / protein domain specific binding / calcium ion binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / magnesium ion binding / positive regulation of transcription by RNA polymerase II / ATP binding / identical protein binding / nucleus / cytoplasmSimilarity search - Function Helix Hairpins - #2040 / Myocardin-like / RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / SAP domain superfamily / SAP domain / SAP motif profile. / Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation ...Helix Hairpins - #2040 / Myocardin-like / RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / SAP domain superfamily / SAP domain / SAP motif profile. / Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation / SAP domain / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / Helix Hairpins / ATPase, nucleotide binding domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / Helix non-globular / Special / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) ORYCTOLAGUS CUNICULUS (rabbit)
![](img/tx_mammal.gif) MUS MUSCULUS (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.1 Å |
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Authors | Mouilleron, S. / Langer, C.A. / Guettler, S. / McDonald, N.Q. / Treisman, R. |
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Citation | Journal: Sci Signal / Year: 2011 Title: Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Authors: Mouilleron, S. / Langer, C.A. / Guettler, S. / McDonald, N.Q. / Treisman, R. |
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History | Deposition | May 19, 2011 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 6, 2011 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 16, 2011 | Group: Database references / Other / Version format compliance |
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Revision 1.2 | Apr 11, 2018 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_abbrev / _citation.page_first ..._citation.journal_abbrev / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name |
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Revision 1.3 | Dec 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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