Entry Database : PDB / ID : 2a40 Structure visualization Downloads & linksTitle Ternary complex of the WH2 domain of WAVE with Actin-DNAse I ComponentsActin, alpha skeletal muscle Deoxyribonuclease-1 Wiskott-Aldrich syndrome protein family member 2 DetailsKeywords STRUCTURAL PROTEIN / WAVE / WH2 / WASP / Actin / DNAse I / arp2/3Function / homology Function and homology informationFunction Domain/homology Component
SCAR complex / regulation of neutrophil mediated cytotoxicity / zymogen granule / regulation of acute inflammatory response / lamellipodium morphogenesis / ameboidal-type cell migration / positive regulation of Arp2/3 complex-mediated actin nucleation / deoxyribonuclease I / Arp2/3 complex binding / postsynaptic actin cytoskeleton organization ... SCAR complex / regulation of neutrophil mediated cytotoxicity / zymogen granule / regulation of acute inflammatory response / lamellipodium morphogenesis / ameboidal-type cell migration / positive regulation of Arp2/3 complex-mediated actin nucleation / deoxyribonuclease I / Arp2/3 complex binding / postsynaptic actin cytoskeleton organization / actin filament-based movement / neutrophil activation involved in immune response / deoxyribonuclease I activity / DNA catabolic process / negative regulation of stress fiber assembly / protein kinase A binding / lamellipodium assembly / cytoskeletal motor activator activity / megakaryocyte development / Fc-gamma receptor signaling pathway involved in phagocytosis / tropomyosin binding / mesenchyme migration / Rac protein signal transduction / troponin I binding / myosin heavy chain binding / protein kinase A regulatory subunit binding / filamentous actin / actin filament bundle / skeletal muscle thin filament assembly / striated muscle thin filament / actin filament bundle assembly / skeletal muscle myofibril / actin monomer binding / RHO GTPases Activate WASPs and WAVEs / vascular endothelial growth factor receptor signaling pathway / skeletal muscle fiber development / positive regulation of lamellipodium assembly / stress fiber / titin binding / ruffle / viral process / actin filament polymerization / filopodium / actin filament / FCGR3A-mediated phagocytosis / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / SH3 domain binding / endocytosis / calcium-dependent protein binding / cell-cell junction / actin cytoskeleton / lamellipodium / nuclear envelope / actin binding / cell body / actin cytoskeleton organization / basolateral plasma membrane / angiogenesis / early endosome / hydrolase activity / cadherin binding / protein domain specific binding / apoptotic process / calcium ion binding / positive regulation of gene expression / magnesium ion binding / protein-containing complex / DNA binding / extracellular exosome / extracellular region / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function SCAR/WAVE family / Deoxyribonuclease I / Deoxyribonuclease I, active site / Deoxyribonuclease I, conservied site / Deoxyribonuclease I signature 2. / Deoxyribonuclease I signature 1. / deoxyribonuclease I / Wiskott Aldrich syndrome homology region 2 / WH2 motif / Actin; Chain A, domain 2 ... SCAR/WAVE family / Deoxyribonuclease I / Deoxyribonuclease I, active site / Deoxyribonuclease I, conservied site / Deoxyribonuclease I signature 2. / Deoxyribonuclease I signature 1. / deoxyribonuclease I / Wiskott Aldrich syndrome homology region 2 / WH2 motif / Actin; Chain A, domain 2 / WH2 domain / WH2 domain profile. / Actin; Chain A, domain 2 / Deoxyribonuclease I; Chain A / Endonuclease/exonuclease/phosphatase / Endonuclease/exonuclease/phosphatase / Endonuclease/Exonuclease/phosphatase family / Endonuclease/exonuclease/phosphatase superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / ATPase, nucleotide binding domain / 4-Layer Sandwich / Nucleotidyltransferase; domain 5 / Roll / Alpha-Beta Complex / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology ADENOSINE-5'-TRIPHOSPHATE / : / Deoxyribonuclease-1 / Actin, alpha skeletal muscle / Wiskott-Aldrich syndrome protein family member 2 Similarity search - ComponentBiological species Oryctolagus cuniculus (rabbit)Bos taurus (cattle)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Chereau, D. / Kerff, F. / Dominguez, R. CitationJournal : Proc.Natl.Acad.Sci.Usa / Year : 2005Title : Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assemblyAuthors : Chereau, D. / Kerff, F. / Graceffa, P. / Grabarek, Z. / Langsetmo, K. / Dominguez, R. History Deposition Jun 27, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 1, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Refinement description / Version format complianceRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.src_method / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Aug 23, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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