[日本語] English
万見
- PDB-3i3j: Crystal Structure of the Bromodomain of Human EP300 -

+
データを開く


IDまたはキーワード:

読み込み中...

-
基本情報

登録情報
データベース: PDB / ID: 3i3j
タイトルCrystal Structure of the Bromodomain of Human EP300
要素Histone acetyltransferase p300
キーワードTRANSFERASE / Structural Genomics Bromodomain / P300 / Consortium / SGC / Structural Genomics Consortium / Bromodomain / Cell cycle / Citrullination / Disease mutation / Host-virus interaction / Metal-binding / Methylation / Nucleus / Phosphoprotein / Transcription / Transcription regulation / Zinc-finger
機能・相同性
機能・相同性情報


behavioral defense response / negative regulation of protein oligomerization / peptidyl-lysine propionylation / histone lactyltransferase (CoA-dependent) activity / peptidyl-lysine crotonylation / peptidyl-lysine butyrylation / histone butyryltransferase activity / swimming / peptide butyryltransferase activity / regulation of tubulin deacetylation ...behavioral defense response / negative regulation of protein oligomerization / peptidyl-lysine propionylation / histone lactyltransferase (CoA-dependent) activity / peptidyl-lysine crotonylation / peptidyl-lysine butyrylation / histone butyryltransferase activity / swimming / peptide butyryltransferase activity / regulation of tubulin deacetylation / histone H3K122 acetyltransferase activity / histone H2B acetyltransferase activity / internal protein amino acid acetylation / peptide 2-hydroxyisobutyryltransferase activity / histone crotonyltransferase activity / protein propionyltransferase activity / NOTCH2 intracellular domain regulates transcription / thigmotaxis / L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor / positive regulation of TORC2 signaling / internal peptidyl-lysine acetylation / histone H4 acetyltransferase activity / cellular response to L-leucine / histone H3 acetyltransferase activity / NFE2L2 regulating ER-stress associated genes / acetylation-dependent protein binding / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / NGF-stimulated transcription / N-terminal peptidyl-lysine acetylation / histone H3K18 acetyltransferase activity / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / histone H3K27 acetyltransferase activity / STAT3 nuclear events downstream of ALK signaling / Polo-like kinase mediated events / NFE2L2 regulating MDR associated enzymes / host-mediated activation of viral transcription / TGFBR3 expression / regulation of androgen receptor signaling pathway / regulation of mitochondrion organization / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / Regulation of FOXO transcriptional activity by acetylation / RUNX3 regulates NOTCH signaling / NOTCH4 Intracellular Domain Regulates Transcription / Nuclear events mediated by NFE2L2 / Regulation of NFE2L2 gene expression / Regulation of gene expression by Hypoxia-inducible Factor / face morphogenesis / platelet formation / NOTCH3 Intracellular Domain Regulates Transcription / regulation of glycolytic process / TRAF6 mediated IRF7 activation / NFE2L2 regulating tumorigenic genes / NFE2L2 regulating anti-oxidant/detoxification enzymes / megakaryocyte development / protein-lysine-acetyltransferase activity / nuclear androgen receptor binding / acyltransferase activity / STAT family protein binding / protein acetylation / Formation of paraxial mesoderm / positive regulation of transforming growth factor beta receptor signaling pathway / acetyltransferase activity / FOXO-mediated transcription of cell death genes / PI5P Regulates TP53 Acetylation / stimulatory C-type lectin receptor signaling pathway / fat cell differentiation / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / Zygotic genome activation (ZGA) / histone acetyltransferase complex / RUNX3 regulates p14-ARF / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / canonical NF-kappaB signal transduction / NF-kappaB binding / negative regulation of gluconeogenesis / pre-mRNA intronic binding / Attenuation phase / somitogenesis / negative regulation of protein-containing complex assembly / positive regulation of DNA-binding transcription factor activity / positive regulation of T-helper 17 cell lineage commitment / cellular response to nutrient levels / histone acetyltransferase activity / skeletal muscle tissue development / histone acetyltransferase / regulation of cellular response to heat / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / Regulation of TP53 Activity through Acetylation / : / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / positive regulation of TORC1 signaling / Transcriptional and post-translational regulation of MITF-M expression and activity / CD209 (DC-SIGN) signaling / negative regulation of autophagy / transcription initiation-coupled chromatin remodeling / lung development / SUMOylation of transcription cofactors / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
類似検索 - 分子機能
Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain ...Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Nuclear receptor coactivator, interlocking / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain / Bromodomain (BrD) profile. / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha
類似検索 - ドメイン・相同性
DI(HYDROXYETHYL)ETHER / Histone acetyltransferase p300
類似検索 - 構成要素
生物種Homo sapiens (ヒト)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 2.33 Å
データ登録者Filippakopoulos, P. / Picaud, S. / Phillips, C. / Pike, A.C.W. / Muniz, J. / Roos, A. / Chaikuad, A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. ...Filippakopoulos, P. / Picaud, S. / Phillips, C. / Pike, A.C.W. / Muniz, J. / Roos, A. / Chaikuad, A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Weigelt, J. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC)
引用ジャーナル: Cell(Cambridge,Mass.) / 年: 2012
タイトル: Histone recognition and large-scale structural analysis of the human bromodomain family.
著者: Filippakopoulos, P. / Picaud, S. / Mangos, M. / Keates, T. / Lambert, J.P. / Barsyte-Lovejoy, D. / Felletar, I. / Volkmer, R. / Muller, S. / Pawson, T. / Gingras, A.C. / Arrowsmith, C.H. / Knapp, S.
履歴
登録2009年6月30日登録サイト: RCSB / 処理サイト: PDBJ
改定 1.02009年7月28日Provider: repository / タイプ: Initial release
改定 1.12011年7月13日Group: Version format compliance
改定 1.22012年3月14日Group: Other
改定 1.32012年4月11日Group: Database references
改定 1.42013年5月8日Group: Other
改定 1.52023年11月1日Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description
カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim / struct_ref_seq_dif / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

-
構造の表示

構造ビューア分子:
MolmilJmol/JSmol

ダウンロードとリンク

-
集合体

登録構造単位
A: Histone acetyltransferase p300
B: Histone acetyltransferase p300
C: Histone acetyltransferase p300
D: Histone acetyltransferase p300
E: Histone acetyltransferase p300
F: Histone acetyltransferase p300
G: Histone acetyltransferase p300
H: Histone acetyltransferase p300
I: Histone acetyltransferase p300
J: Histone acetyltransferase p300
K: Histone acetyltransferase p300
L: Histone acetyltransferase p300
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)176,33318
ポリマ－175,85712
非ポリマー4756
水4,990277
1
A: Histone acetyltransferase p300
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)14,7963
ポリマ－14,6551
非ポリマー1422
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
2
B: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
3
C: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
4
D: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
5
E: Histone acetyltransferase p300
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)14,8924
ポリマ－14,6551
非ポリマー2383
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
6
F: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
7
G: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
8
H: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
9
I: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
10
J: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
11
K: Histone acetyltransferase p300


分子量 (理論値)分子数
合計 (水以外)14,6551
ポリマ－14,6551
非ポリマー00
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
12
L: Histone acetyltransferase p300
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)14,7512
ポリマ－14,6551
非ポリマー961
水181
タイプ名称対称操作数
identity operation1_555x,y,z1
単位格子
Length a, b, c (Å)64.899, 86.186, 149.897
Angle α, β, γ (deg.)90.000, 96.980, 90.000
Int Tables number4
Space group name H-MP1211
非結晶学的対称性 (NCS)NCSドメイン:
IDEns-ID詳細
11A
21B
31C
41D
51E
61F
71G
81H
91I
101J
111K
121L

NCSドメイン領域:

Component-ID: 1 / Ens-ID: 1

Dom-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
1LYSLYSLEULEUCHAIN A AND (RESSEQ 1048:1160 )AA1047 - 116010 - 123
2ILEILEGLYGLYCHAIN B AND (RESSEQ 1048:1160 )BB1048 - 116111 - 124
3LYSLYSLEULEUCHAIN C AND (RESSEQ 1048:1160 )CC1047 - 116010 - 123
4ILEILELEULEUCHAIN D AND (RESSEQ 1048:1160 )DD1048 - 116011 - 123
5LYSLYSGLYGLYCHAIN E AND (RESSEQ 1048:1160 )EE1047 - 116110 - 124
6PHEPHESERSERCHAIN F AND (RESSEQ 1048:1160 )FF1049 - 115912 - 122
7ILEILELEULEUCHAIN G AND (RESSEQ 1048:1160 )GG1048 - 116011 - 123
8ILEILELEULEUCHAIN H AND (RESSEQ 1048:1160 )HH1048 - 116011 - 123
9LYSLYSGLYGLYCHAIN I AND (RESSEQ 1048:1160 )II1047 - 116110 - 124
10ILEILELEULEUCHAIN J AND (RESSEQ 1048:1160 )JJ1048 - 116011 - 123
11LYSLYSLEULEUCHAIN K AND (RESSEQ 1048:1160 )KK1047 - 116010 - 123
12ILEILELEULEUCHAIN L AND (RESSEQ 1048:1160 )LL1048 - 116011 - 123

NCS oper:
IDCodeMatrixベクター
1given(-0.980081, 0.129679, 0.150415), (0.123979, 0.991185, -0.046713), (-0.155147, -0.027134, -0.987519)42.9604, 46.304199, 253.539001
2given(-0.764309, -0.530118, -0.36716), (-0.532586, 0.197922, 0.822909), (-0.36357, 0.824501, -0.433607)72.943901, -104.607002, 198.871994
3given(-0.780579, -0.609981, -0.136454), (-0.321541, 0.204653, 0.924515), (-0.536011, 0.765533, -0.355882)57.3008, -65.9375, 194.514008
4given(0.600789, 0.635302, 0.485226), (-0.562719, -0.095036, 0.821167), (0.567803, -0.766394, 0.3004)-89.964302, -71.3909, 104.362999
5given(-0.641772, 0.61612, -0.456645), (0.446166, -0.184338, -0.87576), (-0.62375, -0.765778, -0.156589)86.882599, 51.337601, 171.279999
6given(-0.345271, -0.14867, -0.926653), (0.047014, -0.988873, 0.141136), (-0.937325, 0.005165, 0.348418)141.188995, 16.1229, 131.367004
7given(0.457678, -0.105365, 0.882853), (-0.029458, -0.994205, -0.103383), (0.88863, 0.021309, -0.45813)-83.514099, 0.987995, 133.462006
8given(0.404766, 0.045177, 0.913304), (0.143185, -0.98959, -0.014508), (0.90314, 0.136643, -0.407021)-113.355003, -7.14379, 175.511993
9given(0.954963, 0.104089, -0.27787), (-0.089026, 0.993819, 0.066323), (0.283056, -0.038598, 0.958326)-5.15837, 2.35306, 39.327301
10given(-0.68918, 0.457658, -0.561765), (0.56164, -0.152442, -0.813217), (-0.457812, -0.875962, -0.151979)101.046997, 96.949997, 156.871994
11given(0.743222, -0.622544, 0.245071), (0.403693, 0.125176, -0.906291), (0.533529, 0.772509, 0.344351)-21.374001, 81.612701, 43.301399

-
要素

#1: タンパク質
Histone acetyltransferase p300 / p300 HAT / E1A-associated protein p300


分子量: 14654.789 Da / 分子数: 12 / 断片: UNP RESIDUES 1040-1161 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: EP300, P300 / プラスミド: pNIC28-Bsa4 / 発現宿主: Escherichia coli (大腸菌) / 株 (発現宿主): BL21(DE3)-R3 / 参照: UniProt: Q09472, histone acetyltransferase
#2: 化合物 ChemComp-CL / CHLORIDE ION / クロリド


分子量: 35.453 Da / 分子数: 2 / 由来タイプ: 合成 / 式: Cl
#3: 化合物 ChemComp-PEG / DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル


分子量: 106.120 Da / 分子数: 2 / 由来タイプ: 合成 / 式: C4H10O3
#4: 化合物 ChemComp-SO4 / SULFATE ION / 硫酸ジアニオン


分子量: 96.063 Da / 分子数: 2 / 由来タイプ: 合成 / 式: SO4
#5: 水 ChemComp-HOH / water


分子量: 18.015 Da / 分子数: 277 / 由来タイプ: 天然 / 式: H2O

-
実験情報

-
実験

実験手法: X線回折 / 使用した結晶の数: 1

-
試料調製

結晶マシュー密度: 2.37 Å3/Da / 溶媒含有率: 48.02 % / Mosaicity: 0.37 °
結晶化温度: 277 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 5.5
詳細: 30w/v PEG 3350, 0.2M ammonium_sulfate, 5.5pH Bis-Tris, VAPOR DIFFUSION, SITTING DROP, temperature 277K

-
データ収集

回折平均測定温度: 100 K
放射光源由来: シンクロトロン / サイト: SLS / ビームライン: X10SA / 波長: 1 Å
検出器タイプ: MARMOSAIC 225 mm CCD / 検出器: CCD / 日付: 2009年3月27日
放射モノクロメーター: Si(111) / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 1 Å / 相対比: 1
反射解像度: 2.33→37.58 Å / Num. all: 69928 / Num. obs: 69648 / % possible obs: 99.6 % / 冗長度: 4.7 % / Rmerge(I) obs: 0.117 / Rsym value: 0.117 / Net I/σ(I): 10.3
反射 シェル解像度: 2.33→2.46 Å / 冗長度: 4.5 % / Rmerge(I) obs: 0.82 / Mean I/σ(I) obs: 2 / Num. unique all: 10054 / Rsym value: 0.82 / % possible all: 99.2

-
位相決定

位相決定手法: 分子置換
Phasing MRRfactor: 43.87 / Model details: Phaser MODE: MR_AUTO
最高解像度最低解像度
Rotation2.5 Å32.3 Å
Translation2.5 Å32.3 Å

-
解析

ソフトウェア
名称バージョン分類NB
SCALA3.3.9データスケーリング
PHASER2.1.4位相決定
PHENIX精密化
PDB_EXTRACT3.005データ抽出
CrystalClearデータ収集
MOSFLMデータ削減
精密化構造決定の手法: 分子置換
開始モデル: 3DWY, 2NXB, 2OO1, 2OSS, 2OUO, 2RFJ, 3DAI, 3D7C

3dwy

2nxb

2oo1

2oss

2ouo

2rfj

3dai

3d7c


解像度: 2.33→32.302 Å / Occupancy max: 1 / Occupancy min: 0.5 / FOM work R set: 0.731 / SU ML: 2.1 / σ(F): 0.01 / 立体化学のターゲット値: ML
Rfactor反射数%反射
Rfree0.275 1842 2.86 %
Rwork0.229 --
all0.231 70225 -
obs0.231 64495 91.84 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL / Bsol: 51.901 Å2 / ksol: 0.345 e/Å3
原子変位パラメータBiso max: 182.53 Å2 / Biso mean: 58.678 Å2 / Biso min: 7.4 Å2
Baniso -1Baniso -2Baniso -3
1-9.412 Å2-0 Å212.514 Å2
2---11.194 Å2-0 Å2
3---1.782 Å2
精密化ステップサイクル: LAST / 解像度: 2.33→32.302 Å
タンパク質核酸リガンド溶媒全体
原子数11074 0 26 277 11377
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.00711442
X-RAY DIFFRACTIONf_angle_d0.99715603
X-RAY DIFFRACTIONf_chiral_restr0.0821671
X-RAY DIFFRACTIONf_plane_restr0.0042006
X-RAY DIFFRACTIONf_dihedral_angle_d16.6184187
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-ID数Refine-IDタイプRms dev position (Å)
11A905X-RAY DIFFRACTIONPOSITIONAL0.062
12B905X-RAY DIFFRACTIONPOSITIONAL0.062
13C920X-RAY DIFFRACTIONPOSITIONAL0.073
14D913X-RAY DIFFRACTIONPOSITIONAL0.073
15E919X-RAY DIFFRACTIONPOSITIONAL0.067
16F871X-RAY DIFFRACTIONPOSITIONAL0.062
17G916X-RAY DIFFRACTIONPOSITIONAL0.069
18H898X-RAY DIFFRACTIONPOSITIONAL0.067
19I911X-RAY DIFFRACTIONPOSITIONAL0.078
110J911X-RAY DIFFRACTIONPOSITIONAL0.065
111K898X-RAY DIFFRACTIONPOSITIONAL0.059
112L894X-RAY DIFFRACTIONPOSITIONAL0.066
LS精密化 シェル

Refine-ID: X-RAY DIFFRACTION / Total num. of bins used: 13

解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
2.33-2.3930.3751160.3093903401975
2.393-2.4640.2971230.2984273439682
2.464-2.5430.381270.34420454784
2.543-2.6340.381300.2744497462786
2.634-2.7390.3221370.2614631476889
2.739-2.8640.3231430.2574798494192
2.864-3.0150.281450.2474924506994
3.015-3.2040.2861480.2465026517496
3.204-3.4510.2871530.2335125527898
3.451-3.7970.2861510.215191534299
3.797-4.3460.2221560.1885245540199
4.346-5.4710.221540.18452605414100
5.471-32.3050.2121590.195360551999
精密化 TLS

手法: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.1348-1.709-0.19551.5378-0.80380.727-0.263-0.2499-0.0768-0.3393-0.4818-0.92290.30670.280.50010.53250.1720.49390.54570.27340.783837.51682.9616139.5481
22.1121-0.95170.13111.0263-0.3291.6056-0.35780.0564-0.09440.1681-0.0657-0.08630.01750.16370.25520.1564-0.01760.01130.17590.04190.168126.86567.4097145.4885
31.02390.37620.27610.3692-0.03520.2840.07790.0415-0.1052-0.0345-0.40360.1123-0.42090.51410.01080.0717-0.06720.02250.1413-0.05180.115913.624411.6177143.5344
4-1.56234.95630.23870.89670.46110.0558-0.05971.1030.4635-0.13220.66230.86820.17220.1173-0.36590.31040.0149-0.05060.52880.05010.52273.76799.8325129.574
5-0.065-0.09550.08290.9234-1.33462.3266-0.07790.3241-0.18320.02710.38370.08920.3372-0.671-0.14270.1031-0.1271-0.08590.36680.1240.040613.682413.2153127.9252
61.8149-0.526-0.42842.70053.54553.45460.512-0.0252-0.2547-0.39520.0646-0.3693-0.53510.0596-0.460.13090.02290.06420.0719-0.03650.203424.47532.7541136.8922
7-1.44230.19470.70172.0892.10291.0589-0.6163-0.0326-0.3677-0.174-0.5167-0.34060.09930.52710.31750.13320.75620.507-2.1216-0.9316-0.153132.28074.9107133.1474
81.9968-0.2526-0.95112.3073-0.81221.52210.15410.13010.4699-0.19640.0629-0.36810.189-0.074-0.11270.1394-0.01520.06940.06480.02930.130423.201616.3631133.9805
96.3854.4954-0.92942.2427-0.64180.75141.2121-0.31071.54521.2293-0.57621.0611-0.41550.2504-0.4290.17240.08690.159600.03140.323514.538422.2395141.1185
101.7786-0.97630.83721.59480.34172.6060.6696-0.27010.5308-0.1434-0.023-0.081-0.4139-0.2426-0.13550.5343-0.1629-0.01930.0885-0.08460.067929.96118.5415146.5241
115.70562.5262-0.77440.8931-1.06280.0120.3051.58810.19620.28760.1988-0.06080.1624-0.0773-0.29420.3024-0.062-0.13130.69960.30820.557537.797213.8727144.3474
12-1.2334-0.1762-0.05570.16212.5615.84960.4477-0.1748-0.1229-0.3238-0.06440.18010.22350.0764-0.29250.83170.1612-0.18180.5181-0.1810.473317.6178-40.466113.8751
131.8107-1.29760.10190.75280.327-1.38431.26790.5906-0.092-1.0555-0.8294-0.2971-0.4476-0.3898-0.2821.24260.4498-0.13690.3456-0.08110.047929.3167-37.5744105.1282
142.95-1.1264-1.41351.65920.61470.08531.13320.5416-0.0917-1.2188-0.6024-0.4581-0.5708-0.2483-0.40620.84180.25440.25940.25450.07420.248544.8852-35.6208109.2633
154.91685.47720.57017.7008-2.45141.41840.6922-0.7628-0.25460.105-0.8972-0.5590.3273-0.2424-0.04590.7179-0.28590.1050.30420.02680.220949.2984-31.8872122.6258
165.15653.28640.85811.81221.79270.13780.44190.0987-1.0601-0.1512-0.1533-0.9974-0.2340.0268-0.29210.60510.0062-0.00460.11650.00580.243633.6008-40.0113115.4884
171.0752-1.1721-1.02654.47793.0079-1.2030.5583-0.03260.2088-1.5576-0.03150.1874-0.7115-0.13720.09830.53560.1762-0.18260.1137-0.00140.069924.3191-35.7738118.2877
182.5710.6303-0.39360.75990.12150.8441.0080.06280.3040.7127-0.76720.0864-0.23690.0105-0.4330.97280.03580.19530.2171-0.00840.255534.8385-28.8209115.9742
191.80130.212-0.5091-0.5531-0.1297-0.0640.99450.0470.915-0.9248-0.5741-0.6522-0.43830.123-0.56121.22320.02480.530.14570.10710.608146.7639-23.777112.636
203.2587-0.4356-1.54591.45750.89273.20710.42520.62940.1259-0.8979-0.691-0.15561.2689-0.06350.17371.20890.42530.33090.35770.16290.272341.2236-25.4654105.9794
211.3776-0.83810.56550.8694-0.5721.4006-0.5440.23040.3349-0.6375-0.573-0.13020.72950.52640.33010.87810.46960.04770.31110.07530.200929.2844-26.0252105.7772
224.1493-1.2512-0.31290.76341.28863.35361.24450.1945-0.42090.0529-0.294-0.09720.2216-0.0624-0.721.13910.2397-0.26120.3137-0.12920.332918.0968-29.8664108.4475
23-1.1026-4.2512-1.7575-3.2147-0.95641.1216-0.56870.5706-0.0759-0.1376-0.35910.0243-0.3378-0.65450.66680.5663-0.2195-0.07950.7161-0.2030.5993-8.4752-8.1035127.449
24-1.56220.5126-0.44721.3931.35671.2444-0.17690.6293-0.11150.09470.63170.0705-0.05590.9384-0.28830.0833-0.0778-0.11320.35390.01850.2644-3.95524.8393133.6928
25-0.17220.3478-0.18411.0262-0.49420.3025-0.09240.1408-0.1275-0.27610.35620.2888-0.1227-0.2628-0.13110.0297-0.03270.00850.14010.0970.31274.32328.6744142.8396
261.24240.05530.8-0.2908-0.04590.71130.3605-0.2381-0.70640.06190.2298-0.09450.2646-0.0703-0.0976-0.07360.069-0.14240.05430.08850.221214.9124-0.5765151.7914
272.8735-0.78781.34740.2677-0.3740.61230.1504-0.0198-0.8879-0.07780.43320.19340.174-0.4133-0.32130.01160.0296-0.05330.07410.06110.18635.6055-3.8907145.5664
281.93251.2480.12031.44580.31230.06060.10880.05050.1141-0.1263-0.329-0.10660.1966-0.32510.0907-0.6027-0.8529-0.2877-0.1191-0.39740.06432.5156-4.5202132.3054
290.36372.42441.5292.10591.9763-0.05420.01670.801-0.87020.89740.1003-0.32060.6619-0.21910.01970.4702-0.06370.03790.4522-0.24140.5389-5.5263-10.7104135.4439
300.72390.38240.11180.16290.03160.3003-0.0362-0.1488-0.3470.1249-0.0555-0.22110.165-0.0715-0.01190.1102-0.0483-0.03720.0864-0.00040.2174-0.9589-0.1432149.2774
31-0.87390.2845-1.84142.135-1.82024.9830.12840.04280.09570.3555-0.14640.3289-0.443-0.15840.09040.0971-0.0281-0.03540.17910.050.0997-0.91369.6336150.4722
323.38523.41990.50312.33152.30512.9589-0.3479-0.04870.74010.22150.31820.87510.11850.17060.04220.23230.0710.02690.32870.14040.3448-11.75484.8191141.5775
33-0.7108-0.05691.43471.0770.86812.4468-0.0973-0.0132-0.1937-0.40850.51190.1134-0.06440.2754-0.30570.545-0.426-0.18581.02110.03560.4758-16.4144-2.8842134.042
340.19670.0563-1.69212.40030.59092.9087-0.2896-0.09440.1475-0.6814-0.09720.3407-0.61950.11520.26370.8719-0.28680.00050.8709-0.0960.679722.9891-15.559585.5592
350.3247-1.6114-2.30991.32930.63581.41430.0848-0.11440.0639-0.0602-0.29980.1997-0.01340.31540.01250.32390.03960.01060.4072-0.18550.438724.8291-6.003188.4427
362.5245-0.85-1.65330.81190.13811.13220.59020.07910.0232-0.4061-0.16770.0113-0.3902-0.1448-0.32130.3508-0.05780.07780.191-0.01810.151737.03162.031495.6082
370.826-0.2027-0.53841.9073-0.6772.4059-0.05340.20660.0046-0.2232-0.3364-0.27020.24380.06340.36810.4329-0.05710.09190.16710.02050.239945.7779-6.5645102.644
382.7818-1.55251.5792.65980.45915.3321-0.04071.2458-0.45520.3234-0.39470.432-1.04610.46470.29340.2757-0.10240.02870.4101-0.14660.117934.5375-9.45888.9357
391.36541.2973-0.62032.2414-0.5872.11550.3589-0.01260.3698-0.0813-0.45710.64350.2991-0.02750.14980.4643-0.00020.11750.484-0.3220.557628.8989-16.700591.8461
400.6773-1.1202-0.04291.69170.53360.5741-0.10650.0335-0.12010.2531-0.21960.56310.37380.01640.30440.5383-0.07680.20140.2082-0.12430.366132.6801-8.0256102.501
410.77296.3731.42612.1022-8.67414.68050.56020.51040.05931.04450.27080.1902-1.44590.2854-0.45030.55160.03290.20850.3002-0.00540.319640.51313.2364110.5947
421.0871-0.1763-0.14210.8468-1.6840.89920.18820.5246-0.06210.4865-0.05170.0794-0.498-0.0705-0.06890.29820.09050.09010.2710.01730.129831.00792.5359104.4223
431.976-3.82223.20933.2004-0.5681.74680.34920.7709-1.0784-0.1292-0.40740.9219-0.2808-0.21550.11210.38340.11790.05750.6446-0.13970.568519.8518-3.260698.7953
44-2.63360.33791.70312.47560.34541.8804-0.33570.1072-0.1575-0.17220.27550.69760.0193-0.62690.19890.7271-0.058-0.00241.23-0.20321.281516.4519-10.179594.2926
454.70851.22230.95671.19161.02274.73780.5287-0.3371-0.6379-0.2206-0.3184-0.2863-0.66011.0149-0.08350.5914-0.24420.03410.654-0.05120.59655.057845.3182133.5282
460.80650.49810.02125.38472.5870.5694-0.18710.179-0.08870.11270.54060.27210.3860.1453-0.04360.32820.05510.07920.21340.01570.239136.15328.5143129.498
474.0961-0.28372.7505-0.8935-0.61883.4317-0.13250.06410.286-0.2801-0.1991-0.021-0.0252-0.00160.25590.2939-0.0246-0.00740.2061-0.0170.239129.310933.3451120.9827
482.19970.4561.1383-0.01020.3930.4896-0.4129-0.12710.3902-0.17780.06950.1388-0.24080.18010.25110.15950.0007-0.12290.149-0.03520.197422.768735.8982123.9213
491.47250.11340.62882.19251.11890.7221-0.31950.02360.1966-0.90560.1391-0.3048-0.60890.03910.1790.34020.023-0.0210.0469-0.03240.114830.579340.5463127.9005
500.8383-0.2827-1.24740.27690.72652.5421-0.1207-0.1454-0.2815-0.2017-0.0477-0.2346-0.18910.60540.14950.2467-0.13750.08620.26650.06460.248245.810944.6019129.5733
511.1557-0.37520.3491.24060.69691.3875-0.10220.1812-0.08920.2156-0.26370.22290.1466-0.05560.05590.1057-0.0330.07410.0811-0.01690.176731.10635.2788136.1918
520.66260.9798-0.85980.66211.0853-2.6411-0.1121-0.6093-0.360.1618-0.2397-0.0376-0.0461-0.22590.12480.15270.0403-0.06780.21630.05890.076438.319631.7849141.8944
535.14932.1131-0.32610.9089-2.07342.91910.5463-0.2584-0.8912-0.50960.1140.03470.48920.0099-0.57240.6823-0.0685-0.11530.33190.06960.452546.485235.3587144.5457
54-0.89361.1618-0.86992.9450.75851.60230.00020.26290.13520.05860.13710.4382-0.05440.8229-0.03650.2802-0.02830.07850.4937-0.21420.643151.527242.9732144.0111
550.24660.04160.26211.4449-0.94280.4212-0.0389-0.42810.4125-0.1192-0.13830.3232-0.0448-0.20780.20961.47010.3349-0.24341.4982-0.73381.723629.34522.131771.0172
56-0.20350.2123-0.34212.62912.31951.76630.37840.0585-0.1985-0.493-0.36210.77960.47380.19240.01131.15330.5825-0.60691.0567-0.71051.415332.4684-6.114770.1876
570.1910.08780.01514.25231.17860.18360.4764-0.16840.0183-1.6179-0.9792-0.4909-0.2189-0.29920.32530.81460.54050.20610.69290.15450.311952.6978-13.098776.8704
58-0.55980.856-0.40222.1340.25382.6606-0.0774-0.5094-0.4259-0.9531-0.1827-0.8714-0.4977-0.02-0.06391.08380.31580.68110.47890.43170.73662.2913-6.384274.4809
59-1.0561-0.4433-1.78680.3876-1.09375.4475-0.1955-1.09320.2308-1.2661-0.73230.6883-0.07110.80050.13820.91160.5962-0.45440.5141-1.0565-1.016244.9681-4.631574.6854
600.3380.7181-0.84945.40771.91371.21510.2175-0.19850.1735-1.5855-0.25861.2549-0.1681-0.08870.35231.22910.5173-0.57370.8142-0.641.02238.60352.227170.3848
610.39591.7711.1373-2.4244-5.50382.3886-0.1969-0.09210.0708-1.2568-0.51670.4920.2968-0.04460.43721.53810.6385-0.25090.5341-0.24580.540845.4861-3.116264.7019
620.8472.31221.89446.26095.09053.1138-0.6791-0.5391-0.0869-3.018-0.329-0.343-1.1043-0.59660.71081.9190.57860.43260.40980.07910.287954.4764-7.760365.8548
633.06923.61370.53061.49581.62192.909-1.2319-0.517-1.1114-1.96110.2693-0.9347-0.8521-0.42680.62071.52520.38670.63180.32320.09610.54154.4375-16.595863.6538
643.6544-0.97552.21560.9456-2.25032.9759-0.60810.3550.3070.17310.5525-0.09261.64420.76660.04231.81990.3592-0.62880.6595-0.01320.538936.397-8.000559.6227
655.2911-2.55532.76177.8442-1.3983.00260.14931.05230.1531-1.0557-0.41270.0890.68540.44260.26591.16190.2911-0.12420.5289-0.01820.333827.578728.360796.9893
663.72590.90195.08762.66345.97958.5805-0.4043-0.5110.5065-0.3567-0.05850.03960.1861-0.56390.45480.34830.0505-0.1180.2467-0.12890.195425.335127.3798106.5067
676.2688-4.0491-2.38334.67410.01844.4594-0.4450.5654-0.2930.7867-0.64330.46860.1866-0.44770.71360.319-0.02910.0510.2897-0.16060.304326.558724.4356115.5722
68-0.2193-0.5720.071.44980.73751.9573-0.14790.0338-0.26070.0787-0.45170.21210.4647-0.11260.28780.4689-0.04050.13390.07610.01090.10935.711223.4816122.6224
69-1.86972.2022-1.37286.9195-0.1393-3.4504-0.37630.39160.3661.59880.67010.09080.16770.2577-0.15990.48780.1218-0.06660.33190.06370.44649.834125.7407126.5363
700.0948-0.005-0.07832.33150.21230.2969-0.02920.0364-0.0865-0.6137-0.0112-0.01350.22720.0570.04960.32120.05430.16510.08630.04310.180342.089125.1599112.8622
714.21120.28312.97945.0987-3.71691.80530.81680.50790.2272-0.6137-0.22770.35120.4180.6178-0.53730.788-0.00710.1180.1274-0.02430.120834.843523.9111100.7102
720.80950.41670.56111.64570.39213.46410.02820.0756-0.181-0.5343-0.3239-0.41971.02890.15720.2950.48240.0530.1980.10950.04030.219539.739414.9733116.8446
732.7283-1.18281.04560.9811-1.3054.41820.3102-0.31140.248-0.6277-0.32380.05751.2341-0.05550.18330.4481-0.04470.160.1557-0.05880.195332.362312.9589120.1359
744.44933.4488-2.35573.7222-3.36432.0280.31080.4429-0.3959-0.224-0.1786-0.3107-0.0016-0.969-0.30690.65340.01640.00450.2628-0.05010.188925.888214.7892110.4411
752.53860.21081.43212.37235.59013.3092-0.25960.5374-0.1603-1.1013-0.38790.4247-1.28410.11180.45940.71970.0794-0.17390.6855-0.21560.616823.434616.9119101.3949
760.7222-0.67580.09780.52170.9920.54870.40370.15920.63190.954-0.1922-0.80720.5247-0.2524-0.12240.9371-0.2363-0.0790.34860.19820.832660.6707-14.6914103.9433
771.4379-1.20051.8592-0.0323-0.59563.1244-0.84260.63872.6369-0.0309-1.2891-1.5265-0.05630.65010.62140.0983-0.00840.68140.13781.0451-0.235157.9486-19.320185.464
780.76810.1318-1.77752.36650.34450.788-0.1051-0.51590.0433-0.8311-0.4310.45250.42840.46610.29630.65190.5372-0.17240.6512-0.21570.384839.339-17.488179.4809
790.4472-0.88960.44130.7049-0.0635.67450.12690.1698-0.5123-0.0635-0.88630.7182-0.9340.31570.29140.57410.0132-0.03080.3921-0.49050.522534.5258-24.470484.2138
800.047-0.32230.05524.0681-1.37121.0071-0.01570.12410.22130.8724-0.4728-0.65630.08980.06160.36570.34670.04280.1190.19960.14250.372250.1901-16.418594.8092
810.9135-0.25181.74354.5586-2.18955.3719-0.3343-0.0056-0.09150.3002-0.9315-0.16350.98390.44570.86620.4718-0.07160.12190.29130.13550.316952.2068-23.144998.6654
823.09440.45791.69830.5883-1.2691-0.93710.30170.48470.0354-0.2477-0.51780.28640.1990.5010.07440.42220.10450.27150.37830.03980.247648.2499-27.523789.9147
83-0.6472-0.857-0.64721.98793.67311.68240.97460.5088-0.2048-0.867-0.62740.1384-0.82290.2081-0.43870.83550.2315-0.08040.5405-0.28450.319743.0109-32.60581.8598
840.9024-0.9663-0.45092.78430.72361.28240.21750.1362-0.2021-1.2041-0.689-0.34780.376-0.41760.20390.65830.2730.36770.42720.02980.442453.3211-30.337782.1533
85-0.28050.27210.9641.54510.78570.1361-0.2274-0.7317-0.9129-0.04970.0764-0.1315-0.12430.18770.09010.2720.13310.09150.65730.45970.403563.8156-28.446192.7541
864.4972-2.8783-3.36162.1471-0.21275.77360.3213-0.73080.0477-0.12610.68470.14640.10710.3014-0.86560.4675-0.1677-0.03211.01070.27490.588464.81-25.3519100.7887
873.3097-1.6785-1.2727-0.3137-3.61294.5897-0.13690.1656-0.76220.6047-0.21530.1588-1.61910.02380.35510.65780.0535-0.0770.2039-0.02390.298930.2205-8.4886153.4435
880.2150.0154-0.4652-0.1177-0.3150.8018-0.08930.03950.1416-0.0071-0.1382-0.2614-0.3067-0.43790.01230.0687-0.17080.05620.14420.10170.146431.9076-11.9253140.3064
890.79561.1043-1.18572.1386-1.68391.27630.0962-0.6308-0.1572-0.4236-0.39880.10020.32780.5280.04320.1491-0.0789-0.00330.19760.0060.11327.3745-17.6618128.3207
90-0.1417-3.92572.38791.7904-2.15699.38620.15530.0604-0.4233-0.06060.18030.8372-0.2523-1.7749-0.18140.1707-0.0248-0.07870.54480.02060.26879.1968-20.3674129.7461
910.1786-0.26920.0465-0.07670.241.49820.0529-0.04110.0033-0.0748-0.02720.1248-0.3458-0.4146-0.05640.08880.0232-0.00580.10770.00890.105619.2362-13.2383139.3047
921.75292.53520.30939.15940.42-0.49930.25-0.5216-0.76531.2432-0.0356-0.6753-0.1479-0.2949-0.22660.14280.11410.0791-0.0149-0.05150.133822.9046-12.8328150.0238
930.72970.37531.53690.56420.82522.52650.23370.00140.0590.0752-0.19410.03520.44010.1484-0.11160.1746-0.047-0.03080.13640.01660.08120.5032-23.8955139.1858
944.1379-0.94271.2688-3.3415-2.80571.22690.63570.04360.3361-0.5893-0.3290.14281.04290.0426-0.50780.4799-0.11390.00860.1968-0.06750.309119.4761-30.5043126.2318
95-0.0269-3.64412.42873.0058-4.88847.88020.13080.38640.3441-0.5449-0.5521-0.50550.74660.75540.25550.13070.0112-0.00280.1501-0.07280.144427.864-26.4108132.8186
96-0.3761-0.3337-0.41251.14391.50862.18720.37330.34950.27370.1279-0.1294-0.81310.26340.02370.08690.351-0.0876-0.02120.41920.25580.419835.8719-22.3942142.4669
970.7125-0.0305-0.13191.8093-0.4453-3.94740.0649-0.23930.0297-0.4947-0.063-0.0431-0.18390.2225-0.13090.4355-0.16520.0160.4903-0.05220.324835.9578-18.2349150.9142
980.84651.0403-1.0830.1267-0.21880.37230.119-0.59150.113-0.118-0.1636-0.26720.05870.30780.06290.20450.08470.14690.46030.38340.469265.97612.269887.9564
995.0742-3.1428-3.3182.64963.10894.1040.5871-0.3295-0.5394-0.6613-0.17620.2639-0.74260.2057-0.36940.4382-0.09390.01480.28080.19440.425353.00016.510197.728
1000.2726-0.7302-1.021-0.978-0.02986.40920.49560.04840.0913-0.1345-0.1527-0.5046-0.419-0.1303-0.22550.3019-0.09770.11010.0945-0.01120.231845.39318.67995.5416
1011.3437-0.18551.9512.1388-0.61331.60210.04160.2698-0.2524-0.6873-0.35620.01480.14790.30960.16560.48180.09160.01780.3259-0.02190.238537.76313.664885.4836
1022.8733-0.9014-0.69781.62790.79930.81830.56820.195-0.4221-0.9874-0.5246-0.03730.0144-0.08670.00510.55830.03090.07940.1023-0.04090.198539.60139.895180.1547
1032.97812.5262-1.3018-0.7356-0.44120.6955-0.2003-0.0462-0.8651-0.1281-0.0175-0.147-0.25050.07970.17830.49120.10750.18610.28020.20840.399554.22020.696185.9952
1046.30520.2517-2.72618.5806-4.04347.8831-1.0539-0.0309-0.50351.086-0.23950.7210.91750.87040.91710.58280.09210.4480.29380.19330.52161.57771.768380.0202
1050.04380.8163-0.15820.5612-0.82842.1688-0.0486-0.01550.18790.051-0.2347-0.0214-0.56550.4353-0.07340.6496-0.01040.18510.27840.14940.293657.301611.001383.1135
1060.28970.35580.39961.14610.55550.71030.31650.10890.21510.1684-0.4190.14590.0575-0.1560.06710.65420.12490.03820.1697-0.03290.239142.441117.695387.9579
1077.31852.00511.05010.9952.05873.49280.1195-0.34510.942-0.4135-0.44250.1941-1.2175-0.02160.11060.6691-0.0883-0.01370.16160.02740.249250.481117.244394.0204
1080.18390.09270.24860.4672-0.78460.336-0.0583-0.1435-0.03080.2628-0.3322-0.2878-0.29950.14460.11180.5972-0.3081-0.16710.64870.3820.418266.402213.42891.9785
1093.5073-1.9544-1.38112.11950.76931.1793-0.01260.34850.35990.12630.1811-0.08490.03820.0951-0.1960.90370.30950.11521.09920.22221.0847-1.44741.7462113.85
1102.3662-0.75392.75811.0564-2.23344.4310.1817-0.7146-0.0497-0.70030.14560.09940.9394-0.8101-0.36370.2782-0.2049-0.11550.40840.11690.126111.2943-13.0142117.8659
1113.5204-0.3936-2.67690.69350.29873.1465-0.9826-0.3693-0.28560.30520.58970.0750.74940.47370.35050.27780.04370.06190.13720.010.105628.6684-7.1857128.334
112-0.0563-0.7262-0.52220.417-0.17932.7053-0.17880.29430.2342-0.36380.2592-0.3082-0.759-0.2034-0.03470.3309-0.02330.09820.2230.01370.276523.2338-2.4301121.4017
1135.7362-1.83281.66444.0081-1.63322.0034-0.4023-1.0325-0.260.2910.70220.2384-1.3701-1.1806-0.35120.44310.1616-0.05090.67010.09050.1947.3166-0.6886122.7831
1144.78395.033-0.93255.9511-0.5691-1.146-0.7633-0.38420.4123-0.8056-0.51970.0973-0.2777-1.10111.02410.44590.2473-0.08010.725-0.22160.35817.9042.864113.3297
1155.1817-2.14410.07361.00480.18181.17620.82260.29630.2288-0.3173-0.3863-0.1645-0.2201-0.3648-0.41690.37870.02120.05880.26170.02420.196719.8772-4.4218112.6424
1165.73744.6029-0.03913.7091-2.3601-1.385-0.2145-0.8255-0.7375-1.1383-0.3321-1.06620.1854-0.01140.49080.36180.08870.23620.23790.02490.252933.4798-11.3957113.6474
1175.3036-0.1456-0.96572.1827-1.10420.59271.133-0.56710.3043-0.4544-0.7730.03180.51160.278-0.37470.571-0.06490.09380.2788-0.03270.223.3207-15.3234111.706
1183.9028-0.95440.13-0.12031.25541.37010.23771.0421-0.0737-0.34870.0020.13880.39920.2902-0.20840.6549-0.0783-0.24060.63160.0770.549511.2514-10.996105.9037
119-0.40760.25310.56790.39770.44410.2152-0.0764-0.27910.0256-0.04980.00480.0904-0.0848-0.52740.07210.6591-0.0788-0.24721.05360.19120.72452.8489-5.8928105.3491
1201.8956-0.3711.44780.2268-0.65644.190.59230.021-0.3447-0.04270.29690.36290.0738-0.2594-0.82810.69750.12340.10930.82920.22051.233763.402827.7474118.7454
1211.49170.0255-0.1031-3.6097-1.07920.3371-0.0435-0.02560.7242-0.16130.1399-0.4206-0.4778-0.0633-0.18560.76570.01930.18630.35340.00060.626660.607739.4863114.5672
1222.9082-2.81866.03213.67870.52779.57560.2507-0.09870.411-1.7497-0.198-1.0163-0.326-0.5119-0.24680.9893-0.02740.42110.14290.0470.310555.103349.5243107.4005
1230.2291-1.08820.23750.2820.1382.58410.65210.16250.0532-0.4692-0.0767-0.0126-0.25940.0672-0.35581.04610.22980.19780.23250.03030.26248.454245.5038105.8231
1242.7367-0.75845.63295.6083-2.22045.0605-0.2215-0.7853-0.0286-1.55360.521-0.0255-2.0334-1.9838-0.31330.84840.56020.2520.4960.13530.088137.270641.2516100.8964
1252.12032.47991.50033.33682.06876.04-0.5071-0.3267-0.7259-1.81160.4513-0.6893-0.8061-0.58460.25010.98970.12120.29830.19580.08270.225644.413734.711100.607
1260.6013-1.8507-0.90231.5522.24281.61380.3552-0.20750.3151-0.03080.0787-0.2757-0.6456-0.2128-0.35020.47860.05170.20540.30310.1140.328852.530134.2844114.9783
1273.1264-1.939-0.30672.27340.9067-0.02760.2772-0.30820.1137-0.38540.0859-0.8804-0.21030.086-0.07910.37020.05820.38170.4170.2720.659457.887327.6418111.7444
1280.63910.995-0.17531.298-0.11840.41350.22930.0551-0.2029-1.3897-0.1856-0.9609-0.32350.0508-0.03531.07650.00050.63220.21130.04230.569653.545335.94198.9763
1290.34420.97671.17323.51734.31384.3132-0.49340.0629-0.4669-2.45030.3921-0.8394-2.3448-0.0483-0.36211.3748-0.18220.65080.18330.03330.403656.215845.013997.42
1300.27680.6275-0.9426-0.0617-0.47970.98050.2949-0.11360.363-0.13820.3577-0.2817-0.0737-0.2004-0.45950.9732-0.23480.42991.167-0.13491.591570.388634.1203109.5135
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1(CHAIN A AND RESID 1048:1054)A1048 - 1054
2X-RAY DIFFRACTION2(CHAIN A AND RESID 1055:1065)A1055 - 1065
3X-RAY DIFFRACTION3(CHAIN A AND RESID 1066:1079)A1066 - 1079
4X-RAY DIFFRACTION4(CHAIN A AND RESID 1080:1086)A1080 - 1086
5X-RAY DIFFRACTION5(CHAIN A AND RESID 1087:1100)A1087 - 1100
6X-RAY DIFFRACTION6(CHAIN A AND RESID 1101:1108)A1101 - 1108
7X-RAY DIFFRACTION7(CHAIN A AND RESID 1109:1113)A1109 - 1113
8X-RAY DIFFRACTION8(CHAIN A AND RESID 1114:1131)A1114 - 1131
9X-RAY DIFFRACTION9(CHAIN A AND RESID 1132:1149)A1132 - 1149
10X-RAY DIFFRACTION10(CHAIN A AND RESID 1150:1155)A1150 - 1155
11X-RAY DIFFRACTION11(CHAIN A AND RESID 1156:1160)A1156 - 1160
12X-RAY DIFFRACTION12(CHAIN B AND RESID 1048:1054)B1048 - 1054
13X-RAY DIFFRACTION13(CHAIN B AND RESID 1055:1067)B1055 - 1067
14X-RAY DIFFRACTION14(CHAIN B AND RESID 1068:1083)B1068 - 1083
15X-RAY DIFFRACTION15(CHAIN B AND RESID 1084:1094)B1084 - 1094
16X-RAY DIFFRACTION16(CHAIN B AND RESID 1095:1109)B1095 - 1109
17X-RAY DIFFRACTION17(CHAIN B AND RESID 1110:1117)B1110 - 1117
18X-RAY DIFFRACTION18(CHAIN B AND RESID 1118:1128)B1118 - 1128
19X-RAY DIFFRACTION19(CHAIN B AND RESID 1129:1139)B1129 - 1139
20X-RAY DIFFRACTION20(CHAIN B AND RESID 1140:1145)B1140 - 1145
21X-RAY DIFFRACTION21(CHAIN B AND RESID 1146:1154)B1146 - 1154
22X-RAY DIFFRACTION22(CHAIN B AND RESID 1155:1161)B1155 - 1161
23X-RAY DIFFRACTION23(CHAIN C AND RESID 1047:1055)C1047 - 1055
24X-RAY DIFFRACTION24(CHAIN C AND RESID 1056:1067)C1056 - 1067
25X-RAY DIFFRACTION25(CHAIN C AND RESID 1068:1079)C1068 - 1079
26X-RAY DIFFRACTION26(CHAIN C AND RESID 1080:1091)C1080 - 1091
27X-RAY DIFFRACTION27(CHAIN C AND RESID 1092:1101)C1092 - 1101
28X-RAY DIFFRACTION28(CHAIN C AND RESID 1102:1109)C1102 - 1109
29X-RAY DIFFRACTION29(CHAIN C AND RESID 1110:1115)C1110 - 1115
30X-RAY DIFFRACTION30(CHAIN C AND RESID 1116:1136)C1116 - 1136
31X-RAY DIFFRACTION31(CHAIN C AND RESID 1137:1145)C1137 - 1145
32X-RAY DIFFRACTION32(CHAIN C AND RESID 1146:1155)C1146 - 1155
33X-RAY DIFFRACTION33(CHAIN C AND RESID 1156:1160)C1156 - 1160
34X-RAY DIFFRACTION34(CHAIN D AND RESID 1048:1054)D1048 - 1054
35X-RAY DIFFRACTION35(CHAIN D AND RESID 1055:1061)D1055 - 1061
36X-RAY DIFFRACTION36(CHAIN D AND RESID 1062:1082)D1062 - 1082
37X-RAY DIFFRACTION37(CHAIN D AND RESID 1083:1100)D1083 - 1100
38X-RAY DIFFRACTION38(CHAIN D AND RESID 1101:1107)D1101 - 1107
39X-RAY DIFFRACTION39(CHAIN D AND RESID 1108:1115)D1108 - 1115
40X-RAY DIFFRACTION40(CHAIN D AND RESID 1116:1130)D1116 - 1130
41X-RAY DIFFRACTION41(CHAIN D AND RESID 1131:1137)D1131 - 1137
42X-RAY DIFFRACTION42(CHAIN D AND RESID 1138:1149)D1138 - 1149
43X-RAY DIFFRACTION43(CHAIN D AND RESID 1150:1155)D1150 - 1155
44X-RAY DIFFRACTION44(CHAIN D AND RESID 1156:1160)D1156 - 1160
45X-RAY DIFFRACTION45(CHAIN E AND RESID 1047:1056)E1047 - 1056
46X-RAY DIFFRACTION46(CHAIN E AND RESID 1072:1076)E1072 - 1076
47X-RAY DIFFRACTION47(CHAIN E AND RESID 1077:1083)E1077 - 1083
48X-RAY DIFFRACTION48(CHAIN E AND RESID 1084:1090)E1084 - 1090
49X-RAY DIFFRACTION49(CHAIN E AND RESID 1091:1100)E1091 - 1100
50X-RAY DIFFRACTION50(CHAIN E AND RESID 1101:1115)E1101 - 1115
51X-RAY DIFFRACTION51(CHAIN E AND RESID 1116:1142)E1116 - 1142
52X-RAY DIFFRACTION52(CHAIN E AND RESID 1143:1150)E1143 - 1150
53X-RAY DIFFRACTION53(CHAIN E AND RESID 1151:1155)E1151 - 1155
54X-RAY DIFFRACTION54(CHAIN E AND RESID 1156:1161)E1156 - 1161
55X-RAY DIFFRACTION55(CHAIN F AND RESID 1049:1053)F1049 - 1053
56X-RAY DIFFRACTION56(CHAIN F AND RESID 1054:1061)F1054 - 1061
57X-RAY DIFFRACTION57(CHAIN F AND RESID 1072:1083)F1072 - 1083
58X-RAY DIFFRACTION58(CHAIN F AND RESID 1084:1094)F1084 - 1094
59X-RAY DIFFRACTION59(CHAIN F AND RESID 1095:1106)F1095 - 1106
60X-RAY DIFFRACTION60(CHAIN F AND RESID 1107:1117)F1107 - 1117
61X-RAY DIFFRACTION61(CHAIN F AND RESID 1118:1122)F1118 - 1122
62X-RAY DIFFRACTION62(CHAIN F AND RESID 1123:1131)F1123 - 1131
63X-RAY DIFFRACTION63(CHAIN F AND RESID 1132:1147)F1132 - 1147
64X-RAY DIFFRACTION64(CHAIN F AND RESID 1148:1159)F1148 - 1159
65X-RAY DIFFRACTION65(CHAIN G AND RESID 1048:1054)G1048 - 1054
66X-RAY DIFFRACTION66(CHAIN G AND RESID 1055:1060)G1055 - 1060
67X-RAY DIFFRACTION67(CHAIN G AND RESID 1061:1067)G1061 - 1067
68X-RAY DIFFRACTION68(CHAIN G AND RESID 1068:1081)G1068 - 1081
69X-RAY DIFFRACTION69(CHAIN G AND RESID 1082:1087)G1082 - 1087
70X-RAY DIFFRACTION70(CHAIN G AND RESID 1088:1109)G1088 - 1109
71X-RAY DIFFRACTION71(CHAIN G AND RESID 1110:1117)G1110 - 1117
72X-RAY DIFFRACTION72(CHAIN G AND RESID 1118:1138)G1118 - 1138
73X-RAY DIFFRACTION73(CHAIN G AND RESID 1139:1148)G1139 - 1148
74X-RAY DIFFRACTION74(CHAIN G AND RESID 1149:1153)G1149 - 1153
75X-RAY DIFFRACTION75(CHAIN G AND RESID 1154:1160)G1154 - 1160
76X-RAY DIFFRACTION76(CHAIN H AND RESID 1048:1054)H1048 - 1054
77X-RAY DIFFRACTION77(CHAIN H AND RESID 1055:1076)H1055 - 1076
78X-RAY DIFFRACTION78(CHAIN H AND RESID 1077:1085)H1077 - 1085
79X-RAY DIFFRACTION79(CHAIN H AND RESID 1086:1093)H1086 - 1093
80X-RAY DIFFRACTION80(CHAIN H AND RESID 1094:1114)H1094 - 1114
81X-RAY DIFFRACTION81(CHAIN H AND RESID 1115:1120)H1115 - 1120
82X-RAY DIFFRACTION82(CHAIN H AND RESID 1121:1128)H1121 - 1128
83X-RAY DIFFRACTION83(CHAIN H AND RESID 1129:1135)H1129 - 1135
84X-RAY DIFFRACTION84(CHAIN H AND RESID 1136:1150)H1136 - 1150
85X-RAY DIFFRACTION85(CHAIN H AND RESID 1151:1155)H1151 - 1155
86X-RAY DIFFRACTION86(CHAIN H AND RESID 1156:1160)H1156 - 1160
87X-RAY DIFFRACTION87(CHAIN I AND RESID 1047:1054)I1047 - 1054
88X-RAY DIFFRACTION88(CHAIN I AND RESID 1055:1065)I1055 - 1065
89X-RAY DIFFRACTION89(CHAIN I AND RESID 1066:1076)I1066 - 1076
90X-RAY DIFFRACTION90(CHAIN I AND RESID 1077:1093)I1077 - 1093
91X-RAY DIFFRACTION91(CHAIN I AND RESID 1094:1107)I1094 - 1107
92X-RAY DIFFRACTION92(CHAIN I AND RESID 1108:1116)I1108 - 1116
93X-RAY DIFFRACTION93(CHAIN I AND RESID 1117:1131)I1117 - 1131
94X-RAY DIFFRACTION94(CHAIN I AND RESID 1132:1138)I1132 - 1138
95X-RAY DIFFRACTION95(CHAIN I AND RESID 1139:1149)I1139 - 1149
96X-RAY DIFFRACTION96(CHAIN I AND RESID 1150:1155)I1150 - 1155
97X-RAY DIFFRACTION97(CHAIN I AND RESID 1156:1161)I1156 - 1161
98X-RAY DIFFRACTION98(CHAIN J AND RESID 1048:1061)J1048 - 1061
99X-RAY DIFFRACTION99(CHAIN J AND RESID 1062:1069)J1062 - 1069
100X-RAY DIFFRACTION100(CHAIN J AND RESID 1070:1076)J1070 - 1076
101X-RAY DIFFRACTION101(CHAIN J AND RESID 1077:1083)J1077 - 1083
102X-RAY DIFFRACTION102(CHAIN J AND RESID 1084:1098)J1084 - 1098
103X-RAY DIFFRACTION103(CHAIN J AND RESID 1099:1107)J1099 - 1107
104X-RAY DIFFRACTION104(CHAIN J AND RESID 1108:1113)J1108 - 1113
105X-RAY DIFFRACTION105(CHAIN J AND RESID 1114:1124)J1114 - 1124
106X-RAY DIFFRACTION106(CHAIN J AND RESID 1125:1138)J1125 - 1138
107X-RAY DIFFRACTION107(CHAIN J AND RESID 1139:1150)J1139 - 1150
108X-RAY DIFFRACTION108(CHAIN J AND RESID 1151:1160)J1151 - 1160
109X-RAY DIFFRACTION109(CHAIN K AND RESID 1047:1053)K1047 - 1053
110X-RAY DIFFRACTION110(CHAIN K AND RESID 1054:1076)K1054 - 1076
111X-RAY DIFFRACTION111(CHAIN K AND RESID 1077:1087)K1077 - 1087
112X-RAY DIFFRACTION112(CHAIN K AND RESID 1088:1103)K1088 - 1103
113X-RAY DIFFRACTION113(CHAIN K AND RESID 1104:1110)K1104 - 1110
114X-RAY DIFFRACTION114(CHAIN K AND RESID 1111:1116)K1111 - 1116
115X-RAY DIFFRACTION115(CHAIN K AND RESID 1117:1130)K1117 - 1130
116X-RAY DIFFRACTION116(CHAIN K AND RESID 1131:1136)K1131 - 1136
117X-RAY DIFFRACTION117(CHAIN K AND RESID 1137:1148)K1137 - 1148
118X-RAY DIFFRACTION118(CHAIN K AND RESID 1149:1154)K1149 - 1154
119X-RAY DIFFRACTION119(CHAIN K AND RESID 1155:1160)K1155 - 1160
120X-RAY DIFFRACTION120(CHAIN L AND RESID 1048:1054)L1048 - 1054
121X-RAY DIFFRACTION121(CHAIN L AND RESID 1055:1065)L1055 - 1065
122X-RAY DIFFRACTION122(CHAIN L AND RESID 1066:1072)L1066 - 1072
123X-RAY DIFFRACTION123(CHAIN L AND RESID 1073:1077)L1073 - 1077
124X-RAY DIFFRACTION124(CHAIN L AND RESID 1078:1087)L1078 - 1087
125X-RAY DIFFRACTION125(CHAIN L AND RESID 1088:1101)L1088 - 1101
126X-RAY DIFFRACTION126(CHAIN L AND RESID 1102:1107)L1102 - 1107
127X-RAY DIFFRACTION127(CHAIN L AND RESID 1108:1117)L1108 - 1117
128X-RAY DIFFRACTION128(CHAIN L AND RESID 1118:1131)L1118 - 1131
129X-RAY DIFFRACTION129(CHAIN L AND RESID 1132:1153)L1132 - 1153
130X-RAY DIFFRACTION130(CHAIN L AND RESID 1154:1160)L1154 - 1160

+
万見について

-
お知らせ

-
2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

-
2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

+
2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

+
2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

+
2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

-
万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る