登録情報 データベース : PDB / ID : 2xmy 構造の表示 ダウンロードとリンクタイトル Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents 要素CELL DIVISION PROTEIN KINASE 2 詳細 キーワード TRANSFERASE / CELL CYCLE / CDK9 INHIBITOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / G2 Phase / cyclin-dependent protein kinase activity / Y chromosome / Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes / positive regulation of heterochromatin formation ... cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / G2 Phase / cyclin-dependent protein kinase activity / Y chromosome / Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes / positive regulation of heterochromatin formation / p53-Dependent G1 DNA Damage Response / X chromosome / PTK6 Regulates Cell Cycle / regulation of anaphase-promoting complex-dependent catabolic process / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / centriole replication / Regulation of APC/C activators between G1/S and early anaphase / centrosome duplication / Telomere Extension By Telomerase / G0 and Early G1 / Activation of the pre-replicative complex / cellular response to nitric oxide / cyclin-dependent protein kinase holoenzyme complex / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / Activation of ATR in response to replication stress / Cyclin E associated events during G1/S transition / Cyclin A/B1/B2 associated events during G2/M transition / Cajal body / Cyclin A:Cdk2-associated events at S phase entry / condensed chromosome / mitotic G1 DNA damage checkpoint signaling / regulation of mitotic cell cycle / regulation of G2/M transition of mitotic cell cycle / cyclin binding / post-translational protein modification / : / meiotic cell cycle / positive regulation of DNA replication / male germ cell nucleus / potassium ion transport / DNA Damage/Telomere Stress Induced Senescence / CDK-mediated phosphorylation and removal of Cdc6 / Meiotic recombination / SCF(Skp2)-mediated degradation of p27/p21 / Orc1 removal from chromatin / G1/S transition of mitotic cell cycle / Transcriptional regulation of granulopoiesis / G2/M transition of mitotic cell cycle / Cyclin D associated events in G1 / cellular senescence / Regulation of TP53 Degradation / nuclear envelope / Factors involved in megakaryocyte development and platelet production / Processing of DNA double-strand break ends / Senescence-Associated Secretory Phenotype (SASP) / regulation of gene expression / peptidyl-serine phosphorylation / DNA replication / Regulation of TP53 Activity through Phosphorylation / transcription regulator complex / Ras protein signal transduction / chromosome, telomeric region / endosome / chromatin remodeling / protein domain specific binding / cell division / protein phosphorylation / DNA repair / protein serine kinase activity / protein serine/threonine kinase activity / DNA-templated transcription / centrosome / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / magnesium ion binding / signal transduction / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ... Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Wang, S. / Griffiths, G. / Midgley, C.A. / Barnett, A.L. / Cooper, M. / Grabarek, J. / Ingram, L. / Jackson, W. / Kontopidis, G. / McClue, S.J. ...Wang, S. / Griffiths, G. / Midgley, C.A. / Barnett, A.L. / Cooper, M. / Grabarek, J. / Ingram, L. / Jackson, W. / Kontopidis, G. / McClue, S.J. / McInnes, C. / McLachlan, J. / Meades, C. / Mezna, M. / Stuart, I. / Thomas, M.P. / Zheleva, D.I. / Lane, D.P. / Jackson, R.C. / Glover, D.M. / Blake, D.G. / Fischer, P.M. 引用ジャーナル : Chem.Biol. / 年 : 2010タイトル : Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents著者: Wang, S. / Griffiths, G. / Midgley, C.A. / Barnett, A.L. / Cooper, M. / Grabarek, J. / Ingram, L. / Jackson, W. / Kontopidis, G. / Mcclue, S.J. / Mcinnes, C. / Mclachlan, J. / Meades, C. / ... 著者 : Wang, S. / Griffiths, G. / Midgley, C.A. / Barnett, A.L. / Cooper, M. / Grabarek, J. / Ingram, L. / Jackson, W. / Kontopidis, G. / Mcclue, S.J. / Mcinnes, C. / Mclachlan, J. / Meades, C. / Mezna, M. / Stuart, I. / Thomas, M.P. / Zheleva, D.I. / Lane, D.P. / Jackson, R.C. / Glover, D.M. / Blake, D.G. / Fischer, P.M. 履歴 登録 2010年7月29日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2010年11月10日 Provider : repository / タイプ : Initial release改定 1.1 2012年3月28日 Group : Database references / Other ... Database references / Other / Refinement description / Source and taxonomy / Version format compliance 改定 1.2 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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