-Search query
-Search result
Showing 1 - 50 of 58 items for (author: cook & ac)
![](data/emdb/media/40180/emdbimg.jpg)
EMDB-40180:
MsbA bound to cerastecin C
Method: single particle / : Chen Y, Klein D
![](data/emdb/media/26767/emdbimg.jpg)
EMDB-26767:
The 2.19-angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - Complex minus stalk
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/emdb/media/26801/emdbimg.jpg)
EMDB-26801:
The 1.67 Angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - catalytic dimer (Huc2S2L)
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/emdb/media/26802/emdbimg.jpg)
EMDB-26802:
The CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - Full complex focused refinement of stalk
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/emdb/media/27661/emdbimg.jpg)
EMDB-27661:
The 1.52 angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - catalytic dimer (Huc2S2L)
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/pdb/img/7utd.jpg)
PDB-7utd:
The 2.19-angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - Complex minus stalk
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/pdb/img/7uur.jpg)
PDB-7uur:
The 1.67 Angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - catalytic dimer (Huc2S2L)
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/pdb/img/7uus.jpg)
PDB-7uus:
The CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - Full complex focused refinement of stalk
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/pdb/img/8dqv.jpg)
PDB-8dqv:
The 1.52 angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - catalytic dimer (Huc2S2L)
Method: single particle / : Grinter R, Venugopal H, Kropp A, Greening C
![](data/emdb/media/26281/emdbimg.jpg)
EMDB-26281:
TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26282/emdbimg.jpg)
EMDB-26282:
TMEM106B(120-254) doublet amyloid fibril from dementia with Lewy bodies (DLB).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26283/emdbimg.jpg)
EMDB-26283:
Low-resolution map of tau filament from progressive supranuclear palsy (PSP) case 3.
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26284/emdbimg.jpg)
EMDB-26284:
TMEM106B(120-254) singlet amyloid fibril from progressive supranuclear palsy (PSP) case 1.
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26285/emdbimg.jpg)
EMDB-26285:
TMEM106B(120-254) singlet amyloid fibril from progressive supranuclear palsy (PSP) case 2.
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26286/emdbimg.jpg)
EMDB-26286:
TMEM106B(120-254) doublet amyloid fibril from progressive supranuclear palsy (PSP) case 2.
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26268/emdbimg.jpg)
EMDB-26268:
High-resolution map of tau filament from progressive supranuclear palsy (PSP) case 1
Method: helical / : FItzpatrick AWP, Stowell MHB
![](data/emdb/media/26273/emdbimg.jpg)
EMDB-26273:
TMEM106B(120-254) protofilament from progressive supranuclear palsy (PSP) case 2
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26274/emdbimg.jpg)
EMDB-26274:
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 1)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26275/emdbimg.jpg)
EMDB-26275:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 2)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26276/emdbimg.jpg)
EMDB-26276:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 4)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26277/emdbimg.jpg)
EMDB-26277:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type C (case 8)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26278/emdbimg.jpg)
EMDB-26278:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type B case 2 (case 7).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26279/emdbimg.jpg)
EMDB-26279:
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u0z.jpg)
PDB-7u0z:
High-resolution map of tau filament from progressive supranuclear palsy (PSP) case 1
Method: helical / : FItzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u10.jpg)
PDB-7u10:
TMEM106B(120-254) protofilament from progressive supranuclear palsy (PSP) case 2
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u11.jpg)
PDB-7u11:
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 1)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u12.jpg)
PDB-7u12:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 2)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u13.jpg)
PDB-7u13:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 4)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u14.jpg)
PDB-7u14:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type C (case 8)
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u15.jpg)
PDB-7u15:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type B case 2 (case 7).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u16.jpg)
PDB-7u16:
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u17.jpg)
PDB-7u17:
TMEM106B(120-254) T185S singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type B case 2 (case 7).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/pdb/img/7u18.jpg)
PDB-7u18:
TMEM106B(120-254) T185S protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).
Method: helical / : Fitzpatrick AWP, Stowell MHB, Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Mackenzie IRA
![](data/emdb/media/26287/snaps2.jpg)
EMDB-26287:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type C (case 8).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26288/snaps2.jpg)
EMDB-26288:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type B (case 6).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26289/snaps2.jpg)
EMDB-26289:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 5).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26290/snaps2.jpg)
EMDB-26290:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 4).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26291/snaps2.jpg)
EMDB-26291:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 3).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26292/snaps2.jpg)
EMDB-26292:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 3).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26293/snaps2.jpg)
EMDB-26293:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 2).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26294/snaps2.jpg)
EMDB-26294:
TMEM106B(120-254) doublet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 1).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26295/snaps2.jpg)
EMDB-26295:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 1).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/26296/snaps2.jpg)
EMDB-26296:
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).
Method: helical / : Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S, Thierry M, Perneel J, Heeman B, Forgrave LM, DeTure M, DeMarco ML, Cook CN, Rademakers R, Dickson D, Petrucelli L, Stowell MHB, Mackenzie IRA, Fitzpatrick AWP
![](data/emdb/media/12585/snaps2.jpg)
EMDB-12585:
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (closed conformation)
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
![](data/emdb/media/12586/snaps2.jpg)
EMDB-12586:
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (one RBD erect)
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
![](data/emdb/media/12587/snaps2.jpg)
EMDB-12587:
Trimeric SARS-CoV-2 spike ectodomain bound to P008_056 Fab
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
![](data/pdb/media/7nt9/snapsdep.jpg)
PDB-7nt9:
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (closed conformation)
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
![](data/pdb/media/7nta/snapsdep.jpg)
PDB-7nta:
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (one RBD erect)
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
![](data/pdb/media/7ntc/snapsdep.jpg)
PDB-7ntc:
Trimeric SARS-CoV-2 spike ectodomain bound to P008_056 Fab
Method: single particle / : Rosa A, Pye VE, Nans A, Cherepanov P
Pages: