Author results

4NTJ
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STRUCTURE OF THE HUMAN P2Y12 RECEPTOR IN COMPLEX WITH AN ANTITHROMBOTIC DRUG
Descriptor:P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate, CHOLESTEROL, ...
Authors:Zhang, K., Zhang, J., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
Deposit date:2013-12-02
Release date:2014-03-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Nature, 509, 2014
6NYF
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 1 (OA-1)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYG
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 2A (OA-2A)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYJ
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 2B (OA-2B)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYL
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 2C (OA-2C)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYM
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 2D (OA-2D)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYN
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HELICOBACTER PYLORI VACUOLATING CYTOTOXIN A OLIGOMERIC ASSEMBLY 2E (OA-2E)
Descriptor:Vacuolating cytotoxin autotransporter
Authors:Zhang, K., Zhang, H., Li, S., Au, S., Chiu, W.
Deposit date:2019-02-11
Release date:2019-03-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures ofHelicobacter pylorivacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5EJO
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CRYSTAL STRUCTURE OF THE WINGED HELIX DOMAIN IN CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT P90
Descriptor:Chromatin assembly factor 1 subunit p90
Authors:Zhang, K., Gao, Y., Li, J., Burgess, R., Han, J., Liang, H., Zhang, Z., Liu, Y.
Deposit date:2015-11-02
Release date:2016-03-16
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
Nucleic Acids Res., 44, 2016
3J1B
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CRYO-EM STRUCTURE OF 8-FOLD SYMMETRIC RATCPN-ALPHA IN APO STATE
Descriptor:Chaperonin alpha subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1C
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-ALPHA IN APO STATE
Descriptor:Chaperonin alpha subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1E
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-BETA IN APO STATE
Descriptor:Chaperonin beta subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1F
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-BETA IN ATP-BINDING STATE
Descriptor:Chaperonin beta subunit, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
5FGL
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CO-CRYSTAL STRUCTURE OF NICR2_HSP
Descriptor:NicR, 4-oxidanylidene-4-(6-oxidanylidene-1~{H}-pyridin-3-yl)butanoic acid
Authors:Zhang, K., Tang, H., Wu, G., Wang, W., Hu, H., Xu, P.
Deposit date:2015-12-21
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Co-crystal Structure of NicR2_Hsp
To Be Published
5FHP
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SEMET REGULATOR OF NICOTINE DEGRADATION
Descriptor:NicR, GLYCEROL, MALONIC ACID
Authors:Zhang, K., Tang, H., Wu, G., Wang, W., Hu, H., Xu, P.
Deposit date:2015-12-22
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Co-crystal Structure of NicR2_Hsp
To Be Published
5NUG
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MOTOR DOMAINS FROM HUMAN CYTOPLASMIC DYNEIN-1 IN THE PHI-PARTICLE CONFORMATION
Descriptor:Cytoplasmic dynein 1 heavy chain 1, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, K., Foster, H.E., Carter, A.P.
Deposit date:2017-04-30
Release date:2017-06-28
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell, 169, 2017
5NVS
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HUMAN CYTOPLASMIC DYNEIN-1 TAIL IN THE TWISTED N-TERMINUS STATE
Descriptor:dynein heavy chain, dynein intermediate chain, dynein light intermediate chain, ...
Authors:Zhang, K., Foster, H.E., Carter, A.P.
Deposit date:2017-05-04
Release date:2017-06-28
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell, 169, 2017
5NVU
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FULL LENGTH HUMAN CYTOPLASMIC DYNEIN-1 IN THE PHI-PARTICLE CONFORMATION
Descriptor:Dynein motor domain, Dynein tail heavy chain, Dynein intermediate chain, ...
Authors:Zhang, K., Foster, H.E., Carter, A.P.
Deposit date:2017-05-04
Release date:2017-08-09
Last modified:2017-09-06
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell, 169, 2017
5NW4
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HUMAN CYTOPLASMIC DYNEIN-1 BOUND TO DYNACTIN AND AN N-TERMINAL CONSTRUCT OF BICD2
Descriptor:dynein heavy chain, dynein intermediate chain, dynein N-terminal dimerization domain, ...
Authors:Zhang, K., Foster, H.E., Carter, A.P.
Deposit date:2017-05-05
Release date:2017-08-02
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell, 169, 2017
6N34
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN NS1-BP
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B., Chook, Y.M.
Deposit date:2018-11-14
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6N3H
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CRYSTAL STRUCTURE OF KELCH DOMAIN OF THE HUMAN NS1 BINDING PROTEIN
Descriptor:Influenza virus NS1A-binding protein
Authors:Zhang, K., Shang, G., Padavannil, A., Fontoura, B.M.A., Chook, Y.M.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6D00
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CALCARISPORIELLA THERMOPHILA HSP104
Descriptor:Calcarisporiella thermophila Hsp104, ADENOSINE-5'-DIPHOSPHATE
Authors:Zhang, K., Pintilie, G.
Deposit date:2018-04-09
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure, 27, 2019
2GMW
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CRYSTAL STRUCTURE OF D,D-HEPTOSE 1.7-BISPHOSPHATE PHOSPHATASE FROM E. COLI.
Descriptor:D,D-heptose 1,7-bisphosphate phosphatase, ZINC ION
Authors:Zhang, K., DeLeon, G., Wright, G.D., Junop, M.S.
Deposit date:2006-04-07
Release date:2007-04-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.
Biochemistry, 49, 2010
3EPU
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CRYSTAL STRUCTURE OF STM2138, A NOVEL VIRULENCE CHAPERONE IN SALMONELLA
Descriptor:STM2138 Virulence Chaperone
Authors:Zhang, K., Andres, S.N., Hannemann, M., Coombes, B., Junop, M.
Deposit date:2008-09-30
Release date:2009-09-29
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis and quantitative proteomic interactome of a novel virulence chaperone in Salmonella
To be Published
5ADX
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CRYOEM STRUCTURE OF DYNACTIN COMPLEX AT 4.0 ANGSTROM RESOLUTION
Descriptor:ACTIN RELATED PROTEIN 1, ACTIN, CYTOPLASMIC 1, ...
Authors:Zhang, K., Urnavicius, L., Diamant, A.G., Motz, C., Schlage, M.A., Yu, M., Patel, N.A., Robinson, C.V., Carter, A.P.
Deposit date:2015-08-24
Release date:2015-12-30
Last modified:2017-07-19
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The Structure of the Dynactin Complex and its Interaction with Dynein.
Science, 347, 2015
6NUD
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SMALL CONFORMATION OF SSRNA-BOUND CRISPR_CSM COMPLEX
Descriptor:CRISPR system Cms protein Csm2, crRNA, CRISPR type III-associated RAMP protein Csm4, ...
Authors:Zhang, K., Pintilie, G., Li, S., Zhu, Y., Chiu, W., Huang, Z.
Deposit date:2019-01-31
Release date:2019-03-13
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019