Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6PZ1
DownloadVisualize
BU of 6pz1 by Molmil
Crystal Structure of human Indoleamine 2,3-Dioxygenase 1 in complex with PF-06840003 in Active Site and Si site
Descriptor: (3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ...
Authors:Pham, K.N, Lewis-Ballester, A, Yeh, S.R.
Deposit date:2019-07-31
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
J.Am.Chem.Soc., 141, 2019
6PYZ
DownloadVisualize
BU of 6pyz by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site
Descriptor: (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Pham, K.N, Lewis-Ballester, A, Yeh, S.R.
Deposit date:2019-07-31
Release date:2020-01-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
J.Am.Chem.Soc., 141, 2019
6PYY
DownloadVisualize
BU of 6pyy by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site
Descriptor: (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase
Authors:Pham, K.N, Lewis-Ballester, A, Yeh, S.R.
Deposit date:2019-07-31
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
J.Am.Chem.Soc., 141, 2019
6MQ6
DownloadVisualize
BU of 6mq6 by Molmil
Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1
Descriptor: (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ...
Authors:Pham, K.N, Yeh, S.R.
Deposit date:2018-10-09
Release date:2018-11-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1.
J. Am. Chem. Soc., 140, 2018
6DPR
DownloadVisualize
BU of 6dpr by Molmil
Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1
Descriptor: (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, 1,2-ETHANEDIOL, Indoleamine 2,3-dioxygenase 1, ...
Authors:Pham, K.N, Yeh, S.R.
Deposit date:2018-06-09
Release date:2018-11-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1.
J. Am. Chem. Soc., 140, 2018
6DPQ
DownloadVisualize
BU of 6dpq by Molmil
Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1
Descriptor: (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ...
Authors:Pham, K.N, Yeh, S.R.
Deposit date:2018-06-09
Release date:2018-11-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1.
J. Am. Chem. Soc., 140, 2018
6UD5
DownloadVisualize
BU of 6ud5 by Molmil
Crystal structure of human tryptophan 2,3-dioxygenase in complex with carbon monoxide and tryptophan
Descriptor: CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, ...
Authors:Pham, K.N, Lewis-Ballester, A, Yeh, S.R.
Deposit date:2019-09-18
Release date:2021-02-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Conformational Plasticity in Human Heme-Based Dioxygenases.
J.Am.Chem.Soc., 143, 2021
6UBP
DownloadVisualize
BU of 6ubp by Molmil
Crystal structure of a photochemical intermediate of human indoleamine 2,3-dioxygenase 1 in complex with carbon monoxide and tryptophan
Descriptor: CARBON MONOXIDE, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Pham, K.N, Yeh, S.R.
Deposit date:2019-09-12
Release date:2021-02-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Conformational Plasticity in Human Heme-Based Dioxygenases.
J.Am.Chem.Soc., 143, 2021
5TIA
DownloadVisualize
BU of 5tia by Molmil
Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase
Authors:Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L.
Deposit date:2016-10-01
Release date:2016-10-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.441 Å)
Cite:Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Sci Rep, 6, 2016
5WMV
DownloadVisualize
BU of 5wmv by Molmil
Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1
Descriptor: 2-(1H-indol-3-yl)ethanol, CYANIDE ION, Indoleamine 2,3-dioxygenase 1, ...
Authors:Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L.
Deposit date:2017-07-31
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1.
Nat Commun, 8, 2017
5WMU
DownloadVisualize
BU of 5wmu by Molmil
Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase I
Descriptor: CYANIDE ION, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L.
Deposit date:2017-07-31
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1.
Nat Commun, 8, 2017
5WN8
DownloadVisualize
BU of 5wn8 by Molmil
Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1
Descriptor: Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE
Authors:Lewis-Ballester, A, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L, Yeh, S.R.
Deposit date:2017-07-31
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1.
Nat Commun, 8, 2017
5WMX
DownloadVisualize
BU of 5wmx by Molmil
Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1
Descriptor: 2-(1H-indol-3-yl)ethanol, CYANIDE ION, Indoleamine 2,3-dioxygenase 1, ...
Authors:Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.M.
Deposit date:2017-07-31
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1.
Nat Commun, 8, 2017
5TI9
DownloadVisualize
BU of 5ti9 by Molmil
Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161
Descriptor: N'-Formylkynurenine, OXYGEN MOLECULE, PHOSPHATE ION, ...
Authors:Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L.
Deposit date:2016-10-01
Release date:2016-10-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Sci Rep, 6, 2016
5WMW
DownloadVisualize
BU of 5wmw by Molmil
Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1
Descriptor: CYANIDE ION, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Lewis-Ballester, A, Yeh, S.R, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L.
Deposit date:2017-07-31
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1.
Nat Commun, 8, 2017
8W1H
DownloadVisualize
BU of 8w1h by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN3 inhibitor
Descriptor: (6M)-1-[(imidazolidin-1-yl)methyl]-6-(1H-indol-3-yl)-1H-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-02-15
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
8W2K
DownloadVisualize
BU of 8w2k by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3F inhibitor
Descriptor: (6M)-6-(6-fluoro-1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-02-20
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
8VTQ
DownloadVisualize
BU of 8vtq by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PPN3 inhibitor
Descriptor: (6M)-6-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-01-26
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
8VUG
DownloadVisualize
BU of 8vug by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PPN1 inhibitor
Descriptor: (5P)-5-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.
Deposit date:2024-01-29
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
9B1Q
DownloadVisualize
BU of 9b1q by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor
Descriptor: (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-03-13
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.624 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
9AT2
DownloadVisualize
BU of 9at2 by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3 inhibitor
Descriptor: (6M)-6-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-02-26
Release date:2024-08-28
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
8VZV
DownloadVisualize
BU of 8vzv by Molmil
Human TDO (hTDO) in complex with LM10
Descriptor: 6-fluoro-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-1H-indole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Ishigami, I, Yeh, S.-R, Lewis-Ballester, A.
Deposit date:2024-02-12
Release date:2024-08-28
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
9B17
DownloadVisualize
BU of 9b17 by Molmil
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN1 inhibitor
Descriptor: (5P)-5-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ...
Authors:Geeraerts, Z, Yeh, S.-R.
Deposit date:2024-03-13
Release date:2024-08-21
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
6NMF
DownloadVisualize
BU of 6nmf by Molmil
SFX structure of reduced cytochrome c oxidase at room temperature
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ...
Authors:Rousseau, D.L, Yeh, S.-R, Ishigami, I.
Deposit date:2019-01-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Snapshot of an oxygen intermediate in the catalytic reaction of cytochromecoxidase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NMP
DownloadVisualize
BU of 6nmp by Molmil
SFX structure of oxidized cytochrome c oxidase at room temperature
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ...
Authors:Rousseau, D.L, Yeh, S.-R, Ishigami, I.
Deposit date:2019-01-11
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Snapshot of an oxygen intermediate in the catalytic reaction of cytochromecoxidase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019

 

12>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon