6DPR

Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1

Summary for 6DPR

Entry DOI	10.2210/pdb6dpr/pdb
Related	5WMU 5WMV 5WMW 5WMX 5WN8 6DPQ
Descriptor	Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, ... (5 entities in total)
Functional Keywords	indoleamine 2, 3-dioxygenase, heme-containing enzyme, bms-986205, structure-based design, hido1-selective inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	97220.40
Authors	Pham, K.N.,Yeh, S.R. (deposition date: 2018-06-09, release date: 2018-11-07, Last modification date: 2023-11-29)
Primary citation	Pham, K.N.,Yeh, S.R. Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1. J. Am. Chem. Soc., 140:14538-14541, 2018 Cited by PubMed: 30347977 DOI: 10.1021/jacs.8b07994 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation