Author results

2MPI
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SOLUTION STRUCTURE OF B24G INSULIN
Descriptor:insulin chain A, insulin chain B
Authors:Yang, Y., Wickramasinghe, N.P., Hua, Q., Weiss, M.A.
Deposit date:2014-05-19
Release date:2014-12-24
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
5WBT
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SOLUTION STRUCTURE AND DYNAMICS OF AN ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
Descriptor:Insulin
Authors:Glidden, M.D., Yang, Y., Wickramasinghe, N.P., Weiss, M.A.
Deposit date:2017-06-29
Release date:2017-11-15
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
J. Biol. Chem., 293, 2018
2MLI
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NMR STRUCTURE OF B25-(ALPHA, BETA)-DEHYDRO-PHENYLALANINE INSULIN
Descriptor:Insulin
Authors:Yang, Y., Weiss, M.
Deposit date:2014-02-27
Release date:2014-08-20
Last modified:2014-09-03
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
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CRYSTAL STRUCTURE OF HUMAN INSULIN MUTANT B20 D-ALA, B23 D-ALA
Descriptor:Insulin A chain, Insulin B chain
Authors:Menting, J.G., Lawrence, M.C.
Deposit date:2013-11-05
Release date:2014-08-27
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
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INSULIN IN COMPLEX WITH SITE 1 OF THE HUMAN INSULIN RECEPTOR
Descriptor:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
Authors:Lawrence, M.C., Menting, J.G.
Deposit date:2014-01-15
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
5WDM
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AN ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG RESISTS THERMAL INACTIVATION AND EXHIBITS BIOLOGICAL SIGNALING DURATION EQUIVALENT TO THE NATIVE PROTEIN
Descriptor:Single-chain insulin analog
Authors:Yee, V.C., Aldabbagh, K., Peng, Y.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
6CK2
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INSULIN ANALOG CONTAINING A YB26W MUTATION
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Rege, N.K., Yee, V.C., Weiss, M.A.
Deposit date:2018-02-27
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.
J. Biol. Chem., 293, 2018