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6C2R
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AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
6C2T
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AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, (2S,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-2-methyl-4-({3-[(1,3-thiazol-2-yl)amino]isoquinolin-1-yl}methyl)piperidine-4-carboxylic acid, DIMETHYL SULFOXIDE, ...
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
4GQB
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CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX
分子名称:Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4 peptide, ...
著者Antonysamy, S., Bonday, Z., Campbell, R., Doyle, B., Druzina, Z., Gheyi, T., Han, B., Jungheim, L.N., Qian, Y., Rauch, C., Russell, M., Sauder, J.M., Wasserman, S.R., Weichert, K., Willard, F.S., Zhang, A., Emtage, S.
登録日2012-08-22
公開日2012-10-17
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structure of the human PRMT5:MEP50 complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
5KN5
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TGFALPHA/EPIREGULIN COMPLEX WITH NEUTRALIZING ANTIBODY LY3016859
分子名称:Epiregulin Antibody LY3016859 Fab Heavy Chain, Epiregulin Antibody LY3016859 Fab Light Chain, Protransforming growth factor alpha, ...
著者Atwell, S., Boyles, J.S., Clawson, D.K., Druzina, Z., Josef, G.H., Weichert, K., Witcher, D.R.
登録日2016-06-27
公開日2016-08-31
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of selectivity and neutralizing activity of a TGF alpha /epiregulin specific antibody.
Protein Sci., 25, 2016
6CKC
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STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH LLY-283, A POTENT AND SELECTIVE INHIBITOR OF PRMT5, WITH ANTITUMOR ACTIVITY
分子名称:Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
著者Antonysamy, S.
登録日2018-02-27
公開日2018-05-16
最終更新日2018-08-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett, 9, 2018