6C2R
Aurora A ligand complex
Summary for 6C2R
Entry DOI | 10.2210/pdb6c2r/pdb |
Descriptor | Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32218.28 |
Authors | Antonysamy, S.,Pustilnik, A.,Manglicmot, D.,Froning, K.,Weichert, K.,Wasserman, S. (deposition date: 2018-01-08, release date: 2019-01-23, Last modification date: 2024-03-13) |
Primary citation | Gong, X.,Du, J.,Parsons, S.H.,Merzoug, F.F.,Webster, Y.,Iversen, P.W.,Chio, L.C.,Van Horn, R.D.,Lin, X.,Blosser, W.,Han, B.,Jin, S.,Yao, S.,Bian, H.,Ficklin, C.,Fan, L.,Kapoor, A.,Antonysamy, S.,Mc Nulty, A.M.,Froning, K.,Manglicmot, D.,Pustilnik, A.,Weichert, K.,Wasserman, S.R.,Dowless, M.,Marugan, C.,Baquero, C.,Lallena, M.J.,Eastman, S.W.,Hui, Y.H.,Dieter, M.Z.,Doman, T.,Chu, S.,Qian, H.R.,Ye, X.S.,Barda, D.A.,Plowman, G.D.,Reinhard, C.,Campbell, R.M.,Henry, J.R.,Buchanan, S.G. Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene. Cancer Discov, 9:248-263, 2019 Cited by PubMed: 30373917DOI: 10.1158/2159-8290.CD-18-0469 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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