Author results

3H7P
  • Download 3h7p
  • View 3h7p
Molmil generated image of 3h7p
CRYSTAL STRUCTURE OF K63-LINKED DI-UBIQUITIN
Descriptor:Ubiquitin, CADMIUM ION
Authors:Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.
Deposit date:2009-04-28
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture.
Proteins, 77, 2009
3H7S
  • Download 3h7s
  • View 3h7s
Molmil generated image of 3h7s
CRYSTAL STRUCTURES OF K63-LINKED DI- AND TRI-UBIQUITIN REVEAL A HIGHLY EXTENDED CHAIN ARCHITECTURE
Descriptor:Ubiquitin, ZINC ION
Authors:Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.
Deposit date:2009-04-28
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture.
Proteins, 77, 2009
3O65
  • Download 3o65
  • View 3o65
Molmil generated image of 3o65
CRYSTAL STRUCTURE OF A JOSEPHIN-UBIQUITIN COMPLEX: EVOLUTIONARY RESTRAINTS ON ATAXIN-3 DEUBIQUITINATING ACTIVITY
Descriptor:Putative ataxin-3-like protein, Ubiquitin, SODIUM ION
Authors:Weeks, S.D., Grasty, K.C., Hernandez-Cuebas, L., Loll, P.J.
Deposit date:2010-07-28
Release date:2010-11-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of a Josephin-Ubiquitin Complex: EVOLUTIONARY RESTRAINTS ON ATAXIN-3 DEUBIQUITINATING ACTIVITY.
J.Biol.Chem., 286, 2011
4JUS
  • Download 4jus
  • View 4jus
Molmil generated image of 4jus
CRYSTAL STRUCTURE OF A FRAGMENT OF HUMAN HSPB6
Descriptor:Heat shock protein beta-6, GLYCEROL
Authors:Weeks, S.D., Baranova, E.V., Beelen, S., Heirbaut, M., Gusev, N.B., Strelkov, S.V.
Deposit date:2013-03-25
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6
J.Struct.Biol., 2013
4JUT
  • Download 4jut
  • View 4jut
Molmil generated image of 4jut
CRYSTAL STRUCTURE OF A MUTANT FRAGMENT OF HUMAN HSPB6
Descriptor:Heat shock protein beta-6, GLYCEROL
Authors:Weeks, S.D., Baranova, E.V., Beelen, S., Heirbaut, M., Gusev, N.B., Strelkov, S.V.
Deposit date:2013-03-25
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6
J.Struct.Biol., 2013
6Z4U
  • Download 6z4u
  • View 6z4u
Molmil generated image of 6z4u
X-RAY CRYSTALLOGRAPHIC STRUCTURE OF ORF9B FROM SARS-COV-2
Descriptor:Protein 9b, POLYETHYLENE GLYCOL (N=34)
Authors:Weeks, S.D., De Graef, S., Munawar, A.
Deposit date:2020-05-25
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray Crystallographic Structure of Orf9b from SARS-CoV-2
To Be Published
7JNO
  • Download 7jno
  • View 7jno
Molmil generated image of 7jno
X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE NS3 HELICASE DOMAIN FROM TICK-BORNE ENCEPHALITIS VIRUS
Descriptor:Serine protease NS3
Authors:Weeks, S.D., Munwar, A., Lucero, H.A., Bandara, A., Munawar, A.H.
Deposit date:2020-08-05
Release date:2020-08-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of Tickborne Encephalitis Virus NS3-Helicase and implications for drug design
To Be Published
4G2U
  • Download 4g2u
  • View 4g2u
Molmil generated image of 4g2u
CRYSTAL STRUCTURE ANALYSIS OF OSTERTAGIA OSTERTAGI ASP-1
Descriptor:Ancylostoma-secreted protein-like protein, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Weeks, S.D., Borloo, J., Geldhof, P., Vercruysse, J., Strelkov, S.V.
Deposit date:2012-07-13
Release date:2013-03-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Ostertagia ostertagi ASP-1: insights into disulfide-mediated cyclization and dimerization
Acta Crystallogr.,Sect.D, 69, 2013
6FPC
  • Download 6fpc
  • View 6fpc
Molmil generated image of 6fpc
STRUCTURE OF THE PRO-PRO ENDOPEPTIDASE (PPEP-2) FROM PAENIBACILLUS ALVEI
Descriptor:PRO-PRO endopeptidase, ZINC ION, CADMIUM ION, ...
Authors:Weeks, S.D., Klychnikov, O.I., Hensbergen, P.J., Strelkov, S.V.
Deposit date:2018-02-09
Release date:2018-05-30
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.
J. Biol. Chem., 293, 2018
3RUL
  • Download 3rul
  • View 3rul
Molmil generated image of 3rul
NEW STRATEGY TO ANALYZE STRUCTURES OF GLYCOPEPTIDE-TARGET COMPLEXES
Descriptor:Ubiquitin, Dalbavancin, L(+)-TARTARIC ACID, ...
Authors:Economou, N.J., Nahoum, V., Weeks, S.D., Grasty, K.C., Loll, P.J.
Deposit date:2011-05-05
Release date:2012-06-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A carrier protein strategy yields the structure of dalbavancin.
J.Am.Chem.Soc., 134, 2012
3RUM
  • Download 3rum
  • View 3rum
Molmil generated image of 3rum
NEW STRATEGY TO ANALYZE STRUCTURES OF GLYCOPEPTIDE ANTIBIOTIC-TARGET COMPLEXES
Descriptor:Maltose-binding periplasmic protein, Ristocetin, alpha-D-arabinofuranose-(1-2)-alpha-D-mannopyranose-(1-2)-[alpha-L-rhamnopyranose-(1-6)]beta-D-glucopyranose, ...
Authors:Economou, N.J., Weeks, S.D., Grasty, K.C., Nahoum, V., Loll, P.J.
Deposit date:2011-05-05
Release date:2012-06-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A carrier protein strategy yields the structure of dalbavancin.
J.Am.Chem.Soc., 134, 2012
3VFJ
  • Download 3vfj
  • View 3vfj
Molmil generated image of 3vfj
THE STRUCTURE OF MONODECHLORO-TEICOPLANIN IN COMPLEX WITH ITS LIGAND, USING MBP AS A LIGAND CARRIER
Descriptor:Maltose-binding periplasmic protein, C-terminal fused by Cys-Lys-D-Ala-D-Ala, MonodeChloro- Teicoplanin A2-2, ...
Authors:Economou, N.J., Weeks, S.D., Grasty, K.C., Loll, P.J.
Deposit date:2012-01-09
Release date:2013-01-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach.
Acta Crystallogr.,Sect.D, 69, 2013
3VFK
  • Download 3vfk
  • View 3vfk
Molmil generated image of 3vfk
THE STRUCTURE OF MONODECHLORO-TEICOPLANIN IN COMPLEX WITH ITS LIGAND, USING UBIQUITIN AS A LIGAND CARRIER
Descriptor:ubiquitin, C-terminal fused by Cys-Lys-D-Ala-D-Ala, MonodeChloro- Teicoplanin A2-2, ...
Authors:Economou, N.J., Weeks, S.D., Grasty, K.C., Loll, P.J.
Deposit date:2012-01-09
Release date:2013-01-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach.
Acta Crystallogr.,Sect.D, 69, 2013
4G9S
  • Download 4g9s
  • View 4g9s
Molmil generated image of 4g9s
CRYSTAL STRUCTURE OF ESCHERICHIA COLI PLIG IN COMPLEX WITH ATLANTIC SALMON G-TYPE LYSOZYME
Descriptor:Goose-type lysozyme, Inhibitor of g-type lysozyme, CHLORIDE ION, ...
Authors:Leysen, S., Vanderkelen, L., Weeks, S.D., Michiels, C.W., Strelkov, S.V.
Deposit date:2012-07-24
Release date:2012-11-07
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural basis of bacterial defense against g-type lysozyme-based innate immunity.
Cell.Mol.Life Sci., 70, 2013
5HVF
  • Download 5hvf
  • View 5hvf
Molmil generated image of 5hvf
CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-I83)
Descriptor:Carboxypeptidase B2, VHH-i83, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVG
  • Download 5hvg
  • View 5hvg
Molmil generated image of 5hvg
CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-A204)
Descriptor:Carboxypeptidase B2, VHH-a204, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVH
  • Download 5hvh
  • View 5hvh
Molmil generated image of 5hvh
CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TWO INHIBITORY NANOBODIES
Descriptor:Carboxypeptidase B2, VHH-a204, VHH-i83, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5LTW
  • Download 5ltw
  • View 5ltw
Molmil generated image of 5ltw
COMPLEX OF HUMAN 14-3-3 SIGMA CLU1 MUTANT WITH PHOSPHORYLATED HEAT SHOCK PROTEIN B6
Descriptor:14-3-3 protein sigma, Heat shock protein beta-6, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.
Deposit date:2016-09-07
Release date:2017-02-01
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
5LU1
  • Download 5lu1
  • View 5lu1
Molmil generated image of 5lu1
HUMAN 14-3-3 SIGMA CLU3 MUTANT COMPLEXED WITH SHORT HSPB6 PHOSPHOPEPTIDE
Descriptor:14-3-3 protein sigma, Heat shock protein beta-6, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.
Deposit date:2016-09-07
Release date:2017-02-01
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
5LU2
  • Download 5lu2
  • View 5lu2
Molmil generated image of 5lu2
HUMAN 14-3-3 SIGMA COMPLEXED WITH LONG HSPB6 PHOSPHOPEPTIDE
Descriptor:14-3-3 protein sigma, Heat shock protein beta-6
Authors:Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.
Deposit date:2016-09-07
Release date:2017-02-01
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
5LUM
  • Download 5lum
  • View 5lum
Molmil generated image of 5lum
ALPHA-CRYSTALLIN DOMAIN OF HUMAN HSPB6 PATCHED WITH ITS N-TERMINAL PEPTIDE
Descriptor:Heat shock protein beta-6, SULFATE ION
Authors:Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.
Deposit date:2016-09-09
Release date:2017-02-01
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
6GWN
  • Download 6gwn
  • View 6gwn
Molmil generated image of 6gwn
CRYSTAL STRUCTURE OF STABILIZED ACTIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1-W175F) IN COMPLEX WITH TWO INHIBITORY NANOBODIES (VHH-2G-42, VHH-2W-64)
Descriptor:Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64
Authors:Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWP
  • Download 6gwp
  • View 6gwp
Molmil generated image of 6gwp
CRYSTAL STRUCTURE OF STABILIZED ACTIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1-STAB) IN COMPLEX WITH TWO INHIBITORY NANOBODIES (VHH-2G-42, VHH-2W-64)
Descriptor:Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64
Authors:Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWQ
  • Download 6gwq
  • View 6gwq
Molmil generated image of 6gwq
CRYSTAL STRUCTURE OF STABILIZED ACTIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1-STAB) IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-2G-42)
Descriptor:Plasminogen Activator Inhibitor-1, VHH-2g-42
Authors:Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6H9X
  • Download 6h9x
  • View 6h9x
Molmil generated image of 6h9x
KLEBSIELLA PNEUMONIAE SERYL-TRNA SYNTHETASE IN COMPLEX WITH THE INTERMEDIATE ANALOG 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
Descriptor:Serine--tRNA ligase, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, 1,2-ETHANEDIOL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-06
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
Eur.J.Med.Chem., 174, 2019
<123>
170172
PDB entries from 2020-10-21