7AP4

Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA

Summary for 7AP4

• Entry DOI: 10.2210/pdb7ap4/pdb
• Descriptor: Aspartate--tRNA(Asp) ligase, (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid (3 entities in total)
• Functional Keywords: protein-inhibitor complex, trna aminoacylation, ligase
• Biological source: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
• Total number of polymer chains: 2
• Total formula weight: 133342.57

Authors

De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-10-15, release date: 2020-12-09, Last modification date: 2024-01-31)

• Primary citation: Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.; Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.; Molecules, 25:-, 2020; PubMed: 33081246; DOI: 10.3390/molecules25204751

Experimental method

X-RAY DIFFRACTION (2.15 Å)