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6I5Y

Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-adenosine

Summary for 6I5Y
Entry DOI10.2210/pdb6i5y/pdb
Related6HB5 6HB6 6HB7
DescriptorTyrosine--tRNA ligase, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, rossmann fold, trna aminoacylation, ligase
Biological sourceEscherichia coli BL21(DE3)
Total number of polymer chains2
Total formula weight96394.85
Authors
De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2018-11-15, release date: 2019-04-17, Last modification date: 2024-01-24)
Primary citationNautiyal, M.,De Graef, S.,Pang, L.,Gadakh, B.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.
Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173:154-166, 2019
Cited by
PubMed: 30995568
DOI: 10.1016/j.ejmech.2019.04.003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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