Author results

2WB8
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CRYSTAL STRUCTURE OF HASPIN KINASE
Descriptor:SERINE/THREONINE-PROTEIN KINASE HASPIN
Authors:Villa, F., Tortorci, M., Forneris, F., Mattevi, A., Musacchio, A.
Deposit date:2009-02-23
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of the Catalytic Domain of Haspin, an Atypical Kinase Implicated in Chromatin Organization.
Proc.Natl.Acad.Sci.USA, 106, 2009
1WCH
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CRYSTAL STRUCTURE OF PTPL1 HUMAN TYROSINE PHOSPHATASE MUTATED IN COLORECTAL CANCER - EVIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATE RECOGNITION POCKET
Descriptor:PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13, PHOSPHATE ION
Authors:Villa, F., Deak, M., Bloomberg, G.B., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-11-16
Release date:2004-12-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket
J.Biol.Chem., 280, 2005
2V3S
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STRUCTURAL INSIGHTS INTO THE RECOGNITION OF SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASE
Descriptor:SERINE/THREONINE-PROTEIN KINASE OSR1, SERINE/THREONINE-PROTEIN KINASE WNK4, ACETATE ION
Authors:Villa, F., Goebel, J., Rafiqi, F.H., Deak, M., Thastrup, J., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2007-06-21
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights Into the Recognition of Substrates and Activators by the Osr1 Kinase
Embo Rep., 8, 2007
2VWI
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STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET
Descriptor:SERINE/THREONINE-PROTEIN KINASE OSR1, GOLD ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Villa, F., Deak, M., Alessi, D.R., vanAalten, D.M.F.
Deposit date:2008-06-25
Release date:2008-07-08
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the Osr1 Kinase, a Hypertension Drug Target.
Proteins, 73, 2008
2VRX
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STRUCTURE OF AURORA B KINASE IN COMPLEX WITH ZM447439
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide
Authors:Girdler, F., Sessa, F., Patercoli, S., Villa, F., Ridgway, E., Musacchio, A., Taylor, S.S.
Deposit date:2008-04-16
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Molecular Basis of Drug Resistance in Aurora Kinases.
Chem.Biol., 15, 2008
2VGO
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CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH REVERSINE INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine
Authors:D'Alise, A.M., Amabile, G., Iovino, M., Di Giorgio, F.P., Bartiromo, M., Sessa, F., Villa, F., Musacchio, A., Cortese, R.
Deposit date:2007-11-15
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.
Mol.Cancer Ther., 7, 2008
2VGP
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CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide
Authors:Andersen, C.B., Wan, Y., Chang, J.W., Lee, C., Liu, Y., Sessa, F., Villa, F., Nallan, L., Musacchio, A., Gray, N.S.
Deposit date:2007-11-15
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
Acs Chem.Biol., 3, 2008
4B8L
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AURORA B KINASE P353G MUTANT
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, 9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-9H-purin-6-amine
Authors:Sessa, F., Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4B8M
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AURORA B KINASE IN COMPLEX WITH VX-680
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE
Authors:Sessa, F., Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4C2V
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AURORA B KINASE IN COMPLEX WITH THE SPECIFIC INHIBITOR BARASERTIB
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, 2-[5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-3-yl]-N-(3-fluorophenyl)ethanamide
Authors:Sessa, F., Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014
4C2W
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CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH AMP-PNP
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Sessa, F., Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014
2CBI
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE
Descriptor:HYALURONIDASE, SULFATE ION, CHLORIDE ION, ...
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-04
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
2CBJ
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STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE IN COMPLEX WITH PUGNAC
Descriptor:HYALURONIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, CHLORIDE ION
Authors:Rao, F.V., Dorfmueller, H.C., Villa, F., Allwood, M., Eggleston, I.M., van Aalten, D.M.F.
Deposit date:2006-01-05
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J., 25, 2006
3ZTX
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AURORA KINASE SELECTIVE INHIBITORS IDENTIFIED USING A TAXOL-INDUCED CHECKPOINT SENSITIVITY SCREEN.
Descriptor:SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE
Authors:Kwiatkowski, N., Villa, F., Musacchio, A., Gray, N.
Deposit date:2011-07-12
Release date:2012-02-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Acs Chem.Biol., 7, 2012
5HOG
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO DNA2.
Descriptor:DNA polymerase alpha-binding protein, Dna2p
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (3.092 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
5HOI
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO TOF2.
Descriptor:DNA polymerase alpha-binding protein, Topoisomerase 1-associated factor 2
Authors:Simon, A.C., Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
4OUC
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STRUCTURE OF HUMAN HASPIN IN COMPLEX WITH HISTONE H3 SUBSTRATE
Descriptor:Serine/threonine-protein kinase haspin, Histone H3.2, SODIUM ION, ...
Authors:Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2014-02-15
Release date:2014-04-16
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of the chromatin phosphoproteome by the haspin protein kinase.
Mol Cell Proteomics, 13, 2014
5NXQ
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CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF YEAST CTF4 BOUND TO A STAPLED SLD5 CIP
Descriptor:DNA polymerase alpha-binding protein, MET-ASP-ILE-UA1-ILE-ASP-ASP-ILE-LEU-UA2-GLU-LEU-ASP-LYS-GLU, GLYCEROL
Authors:Wu, Y., Pellegrini, L.
Deposit date:2017-05-10
Release date:2017-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.413 Å)
Cite:Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Angew. Chem. Int. Ed. Engl., 56, 2017