6Z10

Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist

Summary for 6Z10

• Entry DOI: 10.2210/pdb6z10/pdb
• Descriptor: Succinate receptor 1, Nanobody6, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, ... (7 entities in total)
• Functional Keywords: g protein-coupled receptor gpcr succinate receptor, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 60283.68

Authors

Haffke, M.,Villard, F. (deposition date: 2020-05-11, release date: 2020-09-16, Last modification date: 2024-01-24)

• Primary citation: Velcicky, J.,Wilcken, R.,Cotesta, S.,Janser, P.,Schlapbach, A.,Wagner, T.,Piechon, P.,Villard, F.,Bouhelal, R.,Piller, F.,Harlfinger, S.,Stringer, R.,Fehlmann, D.,Kaupmann, K.,Littlewood-Evans, A.,Haffke, M.,Gommermann, N.; Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.; J.Med.Chem., 63:9856-9875, 2020; PubMed: 32856916; DOI: 10.1021/acs.jmedchem.0c01020

Experimental method

X-RAY DIFFRACTION (2.269 Å)