2VGP
Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor
Summary for 2VGP
Entry DOI | 10.2210/pdb2vgp/pdb |
Related | 2BFX 2BFY 2VGO |
Descriptor | SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, ... (4 entities in total) |
Functional Keywords | nucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule |
Biological source | XENOPUS LAEVIS (AFRICAN CLAWED FROG) More |
Cellular location | Nucleus: Q6DE08 Chromosome, centromere: O13024 |
Total number of polymer chains | 4 |
Total formula weight | 77653.39 |
Authors | Andersen, C.B.,Wan, Y.,Chang, J.W.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Nallan, L.,Musacchio, A.,Gray, N.S. (deposition date: 2007-11-15, release date: 2008-02-26, Last modification date: 2023-12-13) |
Primary citation | Andersen, C.B.,Wan, Y.,Chang, J.W.,Riggs, B.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Kwiatkowski, N.,Suzuki, M.,Nallan, L.,Heald, R.,Musacchio, A.,Gray, N.S. Discovery of Selective Aminothiazole Aurora Kinase Inhibitors Acs Chem.Biol., 3:180-, 2008 Cited by PubMed: 18307303DOI: 10.1021/CB700200W PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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