4B8M

Aurora B kinase in complex with VX-680

Summary for 4B8M

• Entry DOI: 10.2210/pdb4b8m/pdb
• Related: 2BFX 2BFY 2VGO 2VGP 2VRX 3ZTX 4B8L
• Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total)
• Functional Keywords: cell cycle, cancer
• Biological source: XENOPUS LAEVIS (AFRICAN CLAWED FROG); More
• Cellular location: Nucleus: Q6DE08; Chromosome, centromere: O13024
• Total number of polymer chains: 4
• Total formula weight: 78524.74

Authors

Sessa, F.,Villa, F. (deposition date: 2012-08-28, release date: 2013-07-10, Last modification date: 2024-11-13)

• Primary citation: Sessa, F.,Villa, F.; Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism; To be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)