4B8M

Aurora B kinase in complex with VX-680

Summary for 4B8M

Entry DOI	10.2210/pdb4b8m/pdb
Related	2BFX 2BFY 2VGO 2VGP 2VRX 3ZTX 4B8L
Descriptor	AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total)
Functional Keywords	cell cycle, cancer
Biological source	XENOPUS LAEVIS (AFRICAN CLAWED FROG) More
Cellular location	Nucleus: Q6DE08 Chromosome, centromere: O13024
Total number of polymer chains	4
Total formula weight	78524.74
Authors	Sessa, F.,Villa, F. (deposition date: 2012-08-28, release date: 2013-07-10)
Primary citation	Sessa, F.,Villa, F. Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism To be Published,
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation