4B8M
Aurora B kinase in complex with VX-680
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | AURORA KINASE B-A | polymer | 286 | 33724.0 | 2 | UniProt (Q6DE08) Pfam (PF00069) | XENOPUS LAEVIS (AFRICAN CLAWED FROG) | AURORA/IPL1-RELATED KINASE 2-A, AIRK2-A, XAIRK2-A, SERINE/THREONINE-PROTEIN KINASE 12-A, SERINE/THREONINE-PROTEIN KINASE AURORA-B-A, XAURORA-B |
| 2 | C, D (C, D) | INNER CENTROMERE PROTEIN A | polymer | 44 | 5073.8 | 2 | UniProt (O13024) Pfam (PF03941) | XENOPUS LAEVIS (AFRICAN CLAWED FROG) | XL-INCENP, XINC, XINCENP, MITOTIC PHOSPHOPROTEIN 130 |
| 3 | E, F (A, B) | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 2 | Chemie (VX6) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B: 78 - 361 (UniProt: Q6DE08)
| PDB | External Database | Details |
|---|---|---|
| Ala 77 | - | expression tag |
| Asp 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 77595.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 929.2 | |
| All* | Total formula weight | 78524.7 |
