Author results

1A12
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REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN
Descriptor:REGULATOR OF CHROMOSOME CONDENSATION 1
Authors:Renault, L., Nassar, N., Vetter, I., Becker, J., Roth, M., Wittinghofer, A.
Deposit date:1997-12-19
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.
Nature, 392, 1998
4JHN
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THE CRYSTAL STRUCTURE OF THE RPGR RCC1-LIKE DOMAIN
Descriptor:X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D., Vetter, I., Wittinghofer, A., Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
4JHP
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THE CRYSTAL STRUCTURE OF THE RPGR RCC1-LIKE DOMAIN IN COMPLEX WITH PDE6D
Descriptor:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D., Vetter, I., Wittinghofer, A., Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
5T4R
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NMR SOLUTION STRUCTURE OF THE NAV1.7 SELECTIVE SPIDER VENOM-DERIVED PEPTIDE PN3A
Descriptor:Mu-theraphotoxin-Pn3a
Authors:Rosengren, K.J., Armstrong, D.A., Vetter, I.
Deposit date:2016-08-30
Release date:2017-09-06
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:Analgesia from inhibition of NaV1.7 by novel spider venom-derived peptide Pn3a requires synergy with opioids
To Be Published
4GOJ
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THE CRYSTAL STRUCTURE OF FULL LENGTH ARL3GPPNHP IN COMPLEX WITH UNC119A
Descriptor:ADP-ribosylation factor-like protein 3, Protein unc-119 homolog A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ismail, S., Xiang-Chen, Y., Miertzschke, M., Vetter, I., Koerner, C., Wittinghofer, A.
Deposit date:2012-08-20
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
4GOK
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THE CRYSTAL STRUCTURE OF ARL2GPPNHP IN COMPLEX WITH UNC119A
Descriptor:ADP-ribosylation factor-like protein 2, Protein unc-119 homolog A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ismail, S., Xiang-Chen, Y., Miertzschke, M., Vetter, I., Koerner, C., Wittinghofer, A.
Deposit date:2012-08-20
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
4LFT
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STRUCTURE OF ALPHA-ELAPITOXIN-DPP2D ISOLATED FROM BLACK MAMBA (DENDROASPIS POLYLEPIS) VENOM
Descriptor:Alpha-elapitoxin-Dpp2a
Authors:Wang, C.I.A., Reeks, T., Lewis, R.J., Alewood, P.F., Durek, T.
Deposit date:2013-06-27
Release date:2014-06-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Isolation and Structural and Pharmacological Characterization of alpha-Elapitoxin-Dpp2d, an Amidated Three Finger Toxin from Black Mamba Venom.
Biochemistry, 53, 2014
2KRA
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SOLUTION STRUCTURE OF BV8
Descriptor:Prokineticin Bv8
Authors:Daly, N.L., Craik, D.J., Mobli, M.
Deposit date:2009-12-14
Release date:2010-08-11
Last modified:2014-04-23
Method:SOLUTION NMR
Cite:Chemical synthesis and structure of the prokineticin Bv8
CHEMBIOCHEM, 11, 2010
2MPQ
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SOLUTION STRUCTURE OF THE SODIUM CHANNEL TOXIN HD1A
Descriptor:Hd1a
Authors:Klint, J.K., Mobli, M., King, G.F.
Deposit date:2014-06-01
Release date:2015-03-25
Last modified:2015-05-06
Method:SOLUTION NMR
Cite:Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Br.J.Pharmacol., 172, 2015
2MT7
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SOLUTION STRUCTURE OF SPIDER-VENOM PEPTIDE HS1A
Descriptor:Hs1a
Authors:Klint, J.K., King, G.F., Mobli, M.
Deposit date:2014-08-14
Release date:2015-08-19
Method:SOLUTION NMR
Cite:Nav1.7 inhibitors normalise mechanical responses in chronic visceral hypersensitivity
To be Published
2MXM
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NMR SOLUTION STRUCTURE OF TRTX-TP1A FROM THE TARANTULA THRIXOPELMA PRURIENS
Descriptor:entity
Authors:Rosengren, K.
Deposit date:2015-01-08
Release date:2015-06-03
Last modified:2015-07-15
Method:SOLUTION NMR
Cite:Identification and Characterization of ProTx-III [ mu-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Mol.Pharmacol., 88, 2015
2N7F
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NMR SOLUTION STRUCTURE OF MUO-CONOTOXIN MFVIA
Descriptor:muO-conotoxin MfVIA
Authors:Schroeder, C.I., Mobli, M.
Deposit date:2015-09-09
Release date:2016-04-06
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Development of a mu O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.
J.Biol.Chem., 291, 2016
2N9T
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NMR SOLUTION STRUCTURE OF PROTX-II
Descriptor:Beta/omega-theraphotoxin-Tp2a
Authors:Schroeder, C.I.
Deposit date:2015-12-08
Release date:2016-07-06
Last modified:2016-09-07
Method:SOLUTION NMR
Cite:Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.
J.Biol.Chem., 291, 2016
3T5D
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CRYSTAL STRUCTURE OF SEPTIN 7 IN COMPLEX WITH GDP
Descriptor:Septin-7, GUANOSINE-5'-DIPHOSPHATE
Authors:Zent, E., Wittinghofer, A.
Deposit date:2011-07-27
Release date:2011-08-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical properties of Sept7, a unique septin required for filament formation.
Biol.Chem., 392, 2011
4HHF
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CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED SCORPION ALPHA-TOXIN OD1
Descriptor:Alpha-toxin OD1, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Wang, C.I.A., Lewis, R.J., Alewood, P.F., Durek, T.
Deposit date:2012-10-09
Release date:2013-04-24
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1.
Acs Chem.Biol., 8, 2013
5FZV
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE SPIDER VENOM PEPTIDE U3- SCYTOTOXIN-STH1A
Descriptor:Venom peptide U3-SYTX-Sth1a
Authors:Loening, N.M.
Deposit date:2016-03-15
Release date:2016-06-08
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Characterization of Three Venom Peptides from the Spitting Spider Scytodes Thoracica.
Plos One, 11, 2016
5FZW
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE SPIDER VENOM PEPTIDE U3- SCYTOTOXIN-STH1H
Descriptor:Venom peptide U3-SYTX-Sth1h
Authors:Loening, N.M.
Deposit date:2016-03-15
Release date:2016-06-08
Last modified:2017-06-14
Method:SOLUTION NMR
Cite:Characterization of Three Venom Peptides from the Spitting Spider Scytodes Thoracica.
Plos One, 11, 2016
5FZX
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HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE SPIDER VENOM PEPTIDE U5- SCYTOTOXIN-STH1A
Descriptor:U5-SCYTOTOXIN-STH1A
Authors:Loening, N.M.
Deposit date:2016-03-15
Release date:2016-06-08
Method:SOLUTION NMR
Cite:Characterization of Three Venom Peptides from the Spitting Spider Scytodes Thoracica.
Plos One, 11, 2016
5T3M
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SOLUTION STRUCTURE OF A TRIPLE MUTANT OF HWTX-IV - A POTENT BLOCKER OF NAV1.7
Descriptor:Mu-theraphotoxin-Hs2a
Authors:Rahnama, S., Sharma, G., Mobli, M.
Deposit date:2016-08-25
Release date:2017-09-06
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
PLoS ONE, 12, 2017
6BL9
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NMR SOLUTION STRUCTURE OF U-SLPTX15-SM2A
Descriptor:Sm2a toxin
Authors:Harvey, P.J., Craik, D.J., Durek, T., Dash, T.J.
Deposit date:2017-11-09
Release date:2018-11-14
Method:SOLUTION NMR
Cite:The origin of defense: centipede toxin structure reveals a pre-eukaryotic origin of the CSab defensin superfamily
To Be Published
6CEG
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SOLUTION NMR STRUCTURE OF THE OMEGA CONOTOXIN MOVIB FROM CONUS MONCURI
Descriptor:conotoxin MoVIB
Authors:Rosengren, K.J.
Deposit date:2018-02-11
Release date:2018-03-07
Last modified:2018-09-19
Method:SOLUTION NMR
Cite:Novel analgesic omega-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.
Sci Rep, 8, 2018
1PRE
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PROAEROLYSIN
Descriptor:PROAEROLYSIN
Authors:Parker, M.W., Buckley, J.T., Postma, J.P.M., Tucker, A.D., Tsernoglou, D.
Deposit date:1995-09-15
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature, 367, 1994