7R6P
Solution structure of peptide toxin MIITX2-Mg1a from the venom of the Australian giant red bull ant Myrmecia gulosa
Summary for 7R6P
| Entry DOI | 10.2210/pdb7r6p/pdb |
| NMR Information | BMRB: 30928 |
| Descriptor | U-myrmeciitoxin(02)-Mg1a (1 entity in total) |
| Functional Keywords | molecular mimicry, chemical mimicry, epidermal growth factor receptor, hormone, convergent evolution, venom toxin, toxin |
| Biological source | Myrmecia gulosa (Red bulldog ant) |
| Total number of polymer chains | 1 |
| Total formula weight | 5861.39 |
| Authors | Chin, Y.K.,Eagle, D.,Bankala, K.,Robinson, S.D. (deposition date: 2021-06-23, release date: 2022-02-09, Last modification date: 2024-10-23) |
| Primary citation | Eagles, D.A.,Saez, N.J.,Krishnarjuna, B.,Bradford, J.J.,Chin, Y.K.,Starobova, H.,Mueller, A.,Reichelt, M.E.,Undheim, E.A.B.,Norton, R.S.,Thomas, W.G.,Vetter, I.,King, G.F.,Robinson, S.D. A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed Abstract: Venoms are excellent model systems for studying evolutionary processes associated with predator-prey interactions. Here, we present the discovery of a peptide toxin, MIITX-Mg1a, which is a major component of the venom of the Australian giant red bull ant and has evolved to mimic, both structurally and functionally, vertebrate epidermal growth factor (EGF) peptide hormones. We show that Mg1a is a potent agonist of the mammalian EGF receptor ErbB1, and that intraplantar injection in mice causes long-lasting hypersensitivity of the injected paw. These data reveal a previously undescribed venom mode of action, highlight a role for ErbB receptors in mammalian pain signaling, and provide an example of molecular mimicry driven by defensive selection pressure. PubMed: 35131940DOI: 10.1073/pnas.2112630119 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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