Author results

6ENM
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CRYSTAL STRUCTURE OF MMP12 IN COMPLEX WITH HYDROXAMATE INHIBITOR LP168.
Descriptor:Macrophage metalloelastase, 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]-~{N}-oxidanyl-ethanamide, ZINC ION, ...
Authors:Vera, L., Nuti, E., Rossello, A., Stura, E.A.
Deposit date:2017-10-05
Release date:2018-05-16
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.
J. Med. Chem., 61, 2018
6EOX
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CRYSTAL STRUCTURE OF MMP12 IN COMPLEX WITH CARBOXYLIC INHIBITOR LP165.
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Vera, L., Nuti, E., Rossello, A., Stura, E.A.
Deposit date:2017-10-10
Release date:2018-05-16
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.
J. Med. Chem., 61, 2018
4H3X
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CRYSTAL STRUCTURE OF AN MMP BROAD SPECTRUM HYDROXAMATE BASED INHIBITOR CC27 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN
Descriptor:Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.
Deposit date:2012-09-14
Release date:2013-04-24
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.764 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4H76
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH A BROAD SPECTRUM HYDROXAMATE INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.
Deposit date:2012-09-20
Release date:2013-04-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4H84
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH A SELECTIVE CARBOXYLATE BASED INHIBITOR.
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Antoni, C., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.
Deposit date:2012-09-21
Release date:2013-04-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.592 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
3LIK
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HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Vera, L., Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIL
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HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Vera, L., Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIR
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HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Vera, L., Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LJG
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HUMAN MMP12 IN COMPLEX WITH NON-ZINC CHELATING INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Vera, L., Beau, F.
Deposit date:2010-01-26
Release date:2010-09-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.313 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3TS4
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HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L.
Deposit date:2011-09-12
Release date:2012-06-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.587 Å)
Cite:Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
J.Biol.Chem., 287, 2012
3TSK
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HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L.
Deposit date:2011-09-13
Release date:2012-06-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
J.Biol.Chem., 287, 2012
3TT4
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HUMAN MMP8 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Neutrophil collagenase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L.
Deposit date:2011-09-14
Release date:2012-06-20
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
J.Biol.Chem., 287, 2012
3TVC
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HUMAN MMP13 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L., Cassar-Lajeunesse, E.
Deposit date:2011-09-20
Release date:2012-06-20
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
J.Biol.Chem., 287, 2012
4EFS
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HUMAN MMP12 IN COMPLEX WITH L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Dive, V., Devel, L., Czarny, B., Beau, F., Vera, L.
Deposit date:2012-03-30
Release date:2012-06-20
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
J.Biol.Chem., 287, 2012
4GQL
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470.1
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.
Deposit date:2012-08-23
Release date:2013-02-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GR0
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470B
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GR3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470A
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.494 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GR8
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 IN COMPLEX WITH SELECTIVE PHOSPHINIC INHIBITOR RXP470C
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Beau, F., Devel, L., Cassar-Lajeunesse, E., Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4H30
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR.
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Antoni, C., Stura, E.A., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.
Deposit date:2012-09-13
Release date:2013-04-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4H49
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR.
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Antoni, C., Stura, E.A., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.
Deposit date:2012-09-17
Release date:2013-04-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4HMA
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CRYSTAL STRUCTURE OF AN MMP TWIN CARBOXYLATE BASED INHIBITOR LC20 IN COMPLEX WITH THE MMP-9 CATALYTIC DOMAIN
Descriptor:Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Antoni, C., Vera, L., Nuti, E., Carafa, L., Cassar-Lajeunesse, E., Dive, V., Rossello, A.
Deposit date:2012-10-18
Release date:2013-04-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4I03
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HUMAN MMP12 IN COMPLEX WITH A PEG-LINKED BIFUNCTIONAL L-GLUTAMATE MOTIF INHIBITOR
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Stura, E.A., Vera, L., Devel, L., Cassar-Lajeunesse, E., Dive, V.
Deposit date:2012-11-16
Release date:2013-04-24
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4IYE
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CRYSTAL STRUCTURE OF ADTX1 (RHO-DA1A) FROM EASTERN GREEN MAMBA (DENDROASPIS ANGUSTICEPS)
Descriptor:Toxin AdTx1, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER
Authors:Stura, E.A., Vera, L., Maiga, A.A., Marchetti, C., Lorphelin, A., Bellanger, L., Servant, D., Gilles, N.
Deposit date:2013-01-28
Release date:2013-05-08
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination.
Acta Crystallogr.,Sect.F, 69, 2013
5M4V
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X-RAY STRUCTURE OF THE MAMBAQUARETIN-1, A SELECTIVE ANTAGONIST OF THE VASOPRESSIN TYPE 2 RECEPTOR
Descriptor:Mambaquaretin-1, S-1,2-PROPANEDIOL, CHLORIDE ION
Authors:Stura, E.A., Vera, L., Ciolek, J., Mourier, G., Gilles, N.
Deposit date:2016-10-19
Release date:2017-05-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4EJ5
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF BOTULINUM NEUROTOXIN BONT/A WILD-TYPE
Descriptor:Botulinum neurotoxin A light chain, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Stura, E.A., Vera, L., Dive, V.
Deposit date:2012-04-06
Release date:2012-08-15
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165.
J.Biol.Chem., 287, 2012
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