6ENM
Crystal structure of MMP12 in complex with hydroxamate inhibitor LP168.
Summary for 6ENM
Entry DOI | 10.2210/pdb6enm/pdb |
Related | 6EKN 6ELA |
Descriptor | Macrophage metalloelastase, 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]-~{N}-oxidanyl-ethanamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 36528.33 |
Authors | Vera, L.,Nuti, E.,Rossello, A.,Stura, E.A. (deposition date: 2017-10-05, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A. Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J. Med. Chem., 61:4421-4435, 2018 Cited by PubMed: 29727184DOI: 10.1021/acs.jmedchem.8b00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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