6EKN
Crystal structure of MMP12 in complex with inhibitor BE7.
Summary for 6EKN
Entry DOI | 10.2210/pdb6ekn/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18383.28 |
Authors | Ciccone, L.,Tepshi, L.,Nuti, E.,Rossello, A.,Stura, E.A. (deposition date: 2017-09-26, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A. Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J. Med. Chem., 61:4421-4435, 2018 Cited by PubMed: 29727184DOI: 10.1021/acs.jmedchem.8b00096 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report