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6EKN

Crystal structure of MMP12 in complex with inhibitor BE7.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMacrophage metalloelastasepolymer15917615.71UniProt (P39900)
Pfam (PF00413)
In PDB
Homo sapiens (Human)MME,Macrophage elastase,hME,Matrix metalloproteinase-12,MMP-12
2AZINC IONnon-polymer65.42Chemie (ZN)
3ACALCIUM IONnon-polymer40.13Chemie (CA)
4A(2~{S})-2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]pentanedioic acidnon-polymer454.51Chemie (B9N)
5A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
6waterwater18.0146Chemie (HOH)
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDBExternal DatabaseDetails
Met 105-initiating methionine
Asp 171Phe 171engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight17615.7
Non-Polymers*Number of molecules7
Total formula weight767.6
All*Total formula weight18383.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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