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6EKN

Crystal structure of MMP12 in complex with inhibitor BE7.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
AHIS218
AHIS222
AHIS228
AB9N306

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 302
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues6
Detailsbinding site for residue CA A 303
ChainResidue
AGLY190
AGLY192
AASP194
AHOH414
AHOH448
AASP158

site_idAC4
Number of Residues5
Detailsbinding site for residue CA A 304
ChainResidue
AASP124
AGLU199
AGLU201
AHOH507
AHOH515

site_idAC5
Number of Residues6
Detailsbinding site for residue CA A 305
ChainResidue
AASP175
AGLY176
AGLY178
AILE180
AASP198
AGLU201

site_idAC6
Number of Residues22
Detailsbinding site for residue B9N A 306
ChainResidue
AGLY179
AILE180
AILE180
ALEU181
AALA182
AHIS183
ALEU214
AHIS218
AGLU219
AHIS222
AHIS228
AVAL235
APHE237
APRO238
ATHR239
ATYR240
AZN301
AHOH431
AHOH447
AHOH468
AHOH503
AHOH510

site_idAC7
Number of Residues7
Detailsbinding site for residue EDO A 307
ChainResidue
AASN119
AASN119
AASN120
AARG127
AHOH472
AHOH472
AHOH512

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL
ChainResidueDetails
ATHR215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU219

site_idSWS_FT_FI2
Number of Residues19
DetailsBINDING:
ChainResidueDetails
AHIS168
AASP170
AASP175
AGLY176
AGLY178
AILE180
AHIS183
AGLY190
AGLY192
AASP194
AHIS196
AASP198
AGLU199
AGLU201
AHIS218
AHIS222
AHIS228
AASP124
AASP158

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PDB entries from 2024-06-12

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