6ENM
Crystal structure of MMP12 in complex with hydroxamate inhibitor LP168.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Macrophage metalloelastase | polymer | 159 | 17615.7 | 2 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (Human) | MME,Macrophage elastase,hME,Matrix metalloproteinase-12,MMP-12 |
| 2 | A, B | 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]-~{N}-oxidanyl-ethanamide | non-polymer | 397.4 | 2 | Chemie (LPW) | Homo sapiens (Human) | ||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A, B | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 5 | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A, B: 106 - 263 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Met 105 | - | initiating methionine |
| Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35231.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1297.0 | |
| All* | Total formula weight | 36528.3 |
