4XCT

Crystal structure of a hydroxamate based inhibitor ARP101 (EN73) in complex with the MMP-9 catalytic domain.

Summary for 4XCT

Entry DOI	10.2210/pdb4xct/pdb
Descriptor	Matrix metalloproteinase-9,Matrix metalloproteinase-9, (2~{R})-3-methyl-~{N}-oxidanylidene-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxy-amino]butanamide, ZINC ION, ... (10 entities in total)
Functional Keywords	inhibitor-complex, metalloprotease, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	18965.99
Authors	Stura, E.A.,Tepshi, L.,Nuti, E.,Dive, V.,Cassar-Lajeunesse, E.,Vera, L.,Rossello, A. (deposition date: 2014-12-18, release date: 2015-04-22, Last modification date: 2024-01-10)
Primary citation	Nuti, E.,Cantelmo, A.R.,Gallo, C.,Bruno, A.,Bassani, B.,Camodeca, C.,Tuccinardi, T.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Martinelli, A.,Dive, V.,Albini, A.,Rossello, A. N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity. J.Med.Chem., 58:7224-7240, 2015 Cited by PubMed: 26263024 DOI: 10.1021/acs.jmedchem.5b00367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation