4KUF

Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134 mutant with MTSEA modified Cys-165 causing stretch disorder

Summary for 4KUF

• Entry DOI: 10.2210/pdb4kuf/pdb
• Related: 4EJ5 4EL4 4ELC 4KS6 4KTX
• Descriptor: Botulinum neurotoxin A light chain, ZINC ION, DIMETHYL SULFOXIDE, ... (8 entities in total)
• Functional Keywords: clostridial neurotoxin zinc protease, peptidase_m27, snap 25, covalent inhibition, hydrolase
• Biological source: Clostridium botulinum A
• Total number of polymer chains: 1
• Total formula weight: 52173.16

Authors

Stura, E.A.,Vera, L.,Ptchelkine, D.,Bakirci, H.,Garcia, S.,Dive, V. (deposition date: 2013-05-22, release date: 2014-07-09, Last modification date: 2023-09-20)

• Primary citation: Guitot, K.,Vera, L.,Le Roux, L.,Bregant, S.,Ptchelkine, D.,Beau, F.,Stura, E.A.,Dive, V.; Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A; To be Published,

Experimental method

X-RAY DIFFRACTION (1.697 Å)