4KS6

Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 166-174 stretch

Summary for 4KS6

• Entry DOI: 10.2210/pdb4ks6/pdb
• Related: 4EJ5 4EL4 4ELC 4KTX
• Related PRD ID: PRD_001078
• Descriptor: Botulinum neurotoxin A light chain, Peptide inhibitor MPT-DPP-DAR-G-DPN-NH2, ZINC ION, ... (9 entities in total)
• Functional Keywords: clostridial neurotoxin zinc protease, peptidase_m27, snap 25, covalent inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Clostridium botulinum A; More
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• Total number of polymer chains: 2
• Total formula weight: 52323.25

Authors

Stura, E.A.,Vera, L.,Guitot, K.,Dive, V. (deposition date: 2013-05-17, release date: 2014-06-25, Last modification date: 2023-09-20)

• Primary citation: Guitot, K.,Vera, L.,Le Roux, L.,Bregant, S.,Ptchelkine, D.,Beau, F.,Stura, E.A.,Dive, V.; Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A; To be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)