Author results

5VZX
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CRYSTAL STRUCTURE OF CRENEZUMAB FAB
分子名称:Crenezumab Fab heavy chain, Crenezumab Fab light chain, SULFATE ION, ...
著者Ultsch, M., Wang, W.
登録日2017-05-29
公開日2017-08-09
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin.
Sci Rep, 6, 2016
5VZY
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CRYSTAL STRUCTURE OF CRENEZUMAB FAB IN COMPLEX WITH ABETA
分子名称:Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain, Amyloid beta A4 protein
著者Ultsch, M., Wang, W.
登録日2017-05-29
公開日2017-08-09
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin.
Sci Rep, 6, 2016
5IXS
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LACTATE DEHYDROGENASE IN COMPLEX WITH HYDROXYLACTAM INHIBITOR COMPOUND 9: (6R)-3-[(2-CHLOROPHENYL)SULFANYL]-4-HYDROXY-6-(3-HYDROXYPHENYL)-6-(THIOPHEN-3-YL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
著者Ultsch, M., Eigenbrot, C.
登録日2016-03-23
公開日2016-09-14
最終更新日2016-11-09
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Acs Med.Chem.Lett., 7, 2016
6BAD
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2-CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-12
公開日2018-10-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BAG
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-5-((2-CHLOROPHENYL)THIO)-6'-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-12
公開日2018-10-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BAX
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR 6-(3-AMINOPHENYL)-3-((2-CHLOROPHENYL)THIO)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BAZ
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (S)-5-((2-CHLOROPHENYL)THIO)-6'-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB0
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2-CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB1
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-5-((2-CHLOROPHENYL)THIO)-6'-(4-FLUOROPHENOXY)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
6BB2
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LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (S)-5-((2-CHLOROPHENYL)THIO)-6'-(4-FLUOROPHENOXY)-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO-[2,2'-BIPYRIDIN]-6(1H)-ONE
分子名称:L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ...
著者Ultsch, M., Eigenbrot, C.
登録日2017-10-16
公開日2018-10-24
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase
To Be Published
4I77
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LEBRIKIZUMAB FAB BOUND TO IL-13
分子名称:Lebrikizumab heavy chain, Lebrikizumab light chain, Interleukin-13
著者Eigenbrot, C., Ultsch, M.
登録日2012-11-30
公開日2013-02-06
最終更新日2013-04-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab.
J.Mol.Biol., 425, 2013
5HEZ
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JAK2 KINASE (JH1 DOMAIN) MUTANT P1057A IN COMPLEX WITH TG101209
分子名称:Tyrosine-protein kinase JAK2, CHLORIDE ION, ZINC ION, ...
著者Ultsch, M., Eigenbrot, C.
登録日2016-01-06
公開日2016-11-09
最終更新日2016-11-16
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Sci Transl Med, 8, 2016
3HHR
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HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
分子名称:HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
著者De Vos, A.M., Ultsch, M., Kossiakoff, A.A.
登録日1993-12-30
公開日1994-04-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
1AXI
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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
分子名称:GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
著者Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
登録日1997-10-15
公開日1998-01-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1L6X
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FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C
分子名称:IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN CONSTANT REGION, Minimized B-domain of Protein A Z34C, N-ACETYL-D-GLUCOSAMINE, ...
著者Idusogie, E.E., Presta, L.G., Santoro-Gazzano, H., Totpal, K., Wong, P.Y., Ultsch, M., Meng, Y.G., Mullkerrin, M.G.
登録日2002-03-14
公開日2002-04-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.
J.Immunol., 164, 2000
1A22
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HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
分子名称:GROWTH HORMONE, GROWTH HORMONE RECEPTOR
著者De Vos, A.M., Ultsch, M.
登録日1998-01-15
公開日1998-04-29
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
3V01
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DISCOVERY OF NOVEL ALLOSTERIC MEK INHIBITORS POSSESSING CLASSICAL AND NON-CLASSICAL BIDENTATE SER212 INTERACTIONS.
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, N-{[(2R)-2,3-dihydroxypropyl]oxy}-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Heald, R., Jackson, P., Savy, P., Jones, M., Gancia, E., Burton, B., Newman, R., Boggs, J., Chan, E., Chan, J., Choo, E., Merchant, M., Ultsch, M., Wiesmann, C., Belvin, M., Price, S.
登録日2011-12-07
公開日2012-05-09
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions.
J.Med.Chem., 55, 2012
3V04
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DISCOVERY OF NOVEL ALLOSTERIC MEK INHIBITORS POSSESSING CLASSICAL AND NON-CLASSICAL BIDENTATE SER212 INTERACTIONS.
分子名称:Dual specificity mitogen-activated protein kinase kinase 1, 4-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Heald, R., Jackson, P., Savy, P., Jones, M., Gancia, E., Burton, B., Newman, R., Boggs, J., Chan, E., Chan, J., Choo, E., Merchant, M., Ultsch, M., Wiesmann, C., Belvin, M., Price, S.
登録日2011-12-07
公開日2012-05-09
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions.
J.Med.Chem., 55, 2012
4GVJ
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TYK2 (JH1) IN COMPLEX WITH ADENOSINE DI-PHOSPHATE
分子名称:Non-receptor tyrosine-protein kinase TYK2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Liang, J., Abbema, A.V., Bao, L., Barrett, K., Beresini, M., Berezhkovskiy, L., Blair, W., Chang, C., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liimatta, M., Mantik, P., Menghrajani, K., Murray, J., Sambrone, A., Shao, Y., Shia, S., Shin, Y., Smith, J., Sohn, S., Stanley, M., Tsui, V., Ultsch, M., Wu, L., Zhang, B., Magnuson, S.
登録日2012-08-30
公開日2013-08-14
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
1M1L
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HUMAN SUPPRESSOR OF FUSED (N-TERMINAL DOMAIN)
分子名称:Suppressor of Fused
著者Merchant, M., Vajdos, F.F., Ultsch, M., Maun, H.R., Wendt, U., Cannon, J., Lazarus, R.A., de Vos, A.M., de Sauvage, F.J.
登録日2002-06-19
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
3NYX
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NON-PHOSPHORYLATED TYK2 JH1 DOMAIN WITH QUINOLINE-THIADIAZOLE-THIOPHENE INHIBITOR
分子名称:Non-receptor tyrosine-protein kinase TYK2, N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
著者Eigenbrot, C., Ultsch, M.
登録日2010-07-15
公開日2010-10-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A new regulatory switch in a JAK protein kinase.
Proteins, 79, 2011
3NZ0
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NON-PHOSPHORYLATED TYK2 KINASE WITH CMP6
分子名称:Non-receptor tyrosine-protein kinase TYK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
著者Eigenbrot, C., Ultsch, M.
登録日2010-07-15
公開日2010-10-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A new regulatory switch in a JAK protein kinase.
Proteins, 79, 2011
3TJN
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HTRA1 CATALYTIC DOMAIN, APO FORM
分子名称:Serine protease HTRA1
著者Eigenbrot, C., Ultsch, M.
登録日2011-08-24
公開日2012-05-16
最終更新日2012-06-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJO
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HTRA1 CATALYTIC DOMAIN, MUTATIONALLY INACTIVATED
分子名称:Serine protease HTRA1, B-OCTYLGLUCOSIDE, SULFATE ION, ...
著者Eigenbrot, C., Ultsch, M.
登録日2011-08-24
公開日2012-05-16
最終更新日2012-06-27
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJQ
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N-DOMAIN OF HTRA1
分子名称:Serine protease HTRA1, PLATINUM (II) ION, CHLORIDE ION, ...
著者Eigenbrot, C., Ultsch, M.
登録日2011-08-24
公開日2012-05-16
最終更新日2012-06-27
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012