Author results

1JAN
  • Download 1jan
  • View 1jan
Molmil generated image of 1jan
COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (PHE79 FORM), PRO-LEU-GLY-HYDROXYLAMINE INHIBITOR, CALCIUM ION, ...
Authors:Reinemer, P., Grams, F., Huber, R., Kleine, T., Schnierer, S., Pieper, M., Tschesche, H., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS Lett., 338, 1994
1JAO
  • Download 1jao
  • View 1jao
Molmil generated image of 1jao
COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), N-[(2S)-2-benzyl-3-sulfanylpropanoyl]-L-alanylglycinamide, CALCIUM ION, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1JAP
  • Download 1jap
  • View 1jap
Molmil generated image of 1jap
COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), PRO-LEU-GLY-HYDROXYLAMINE, CALCIUM ION, ...
Authors:Bode, W., Reinemer, P., Huber, R., Kleine, T., Schnierer, S., Tschesche, H.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
EMBO J., 13, 1994
1JAQ
  • Download 1jaq
  • View 1jaq
Molmil generated image of 1jaq
COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), CALCIUM ION, N-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1ZS0
  • Download 1zs0
  • View 1zs0
Molmil generated image of 1zs0
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (S-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-05-23
Release date:2006-05-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
1ZVX
  • Download 1zvx
  • View 1zvx
Molmil generated image of 1zvx
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (R-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-06-03
Release date:2006-05-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
1I73
  • Download 1i73
  • View 1i73
Molmil generated image of 1i73
COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:NEUTROPHIL COLLAGENASE, THREE RESIDUE PEPTIDE INHIBITOR, CALCIUM ION, ...
Authors:Gavuzzo, E., Pochetti, G., Mazza, F., Gallina, C., Gorini, B., D'Alessio, S., Pieper, M., Tschesche, H., Tucker, P.A.
Deposit date:2001-03-07
Release date:2001-03-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
J.Med.Chem., 43, 2000
1I76
  • Download 1i76
  • View 1i76
Molmil generated image of 1i76
COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ...
Authors:Gavuzzo, E., Pochetti, G., Mazza, F., Gallina, C., Gorini, B., D'Alessio, S., Pieper, M., Tschesche, H., Tucker, P.A.
Deposit date:2001-03-08
Release date:2001-03-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
J.Med.Chem., 43, 2000
1ZP5
  • Download 1zp5
  • View 1zp5
Molmil generated image of 1zp5
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A N-HYDROXYUREA INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Campestre, C., Agamennone, M., Tortorella, P., Preziuso, S., Biasone, A., Gavuzzo, E., Pochetti, G., Mazza, F., Tschesche, H., Gallina, C.
Deposit date:2005-05-16
Release date:2005-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8.
Bioorg.Med.Chem.Lett., 16, 2006
1JH1
  • Download 1jh1
  • View 1jh1
Molmil generated image of 1jh1
CRYSTAL STRUCTURE OF MMP-8 COMPLEXED WITH A 6H-1,3,4-THIADIAZINE DERIVED INHIBITOR
Descriptor:Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ...
Authors:Schroder, J., Henke, A., Wenzel, H., Brandstetter, H., Stammler, H.G., Stammler, A., Pfeiffer, W.D., Tschesche, H.
Deposit date:2001-06-27
Release date:2001-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
J.Med.Chem., 44, 2001
1NGL
  • Download 1ngl
  • View 1ngl
Molmil generated image of 1ngl
HUMAN NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (HNGAL), REGULARISED AVERAGE NMR STRUCTURE
Descriptor:PROTEIN (NGAL)
Authors:Coles, M., Diercks, T., Muehlenweg, B., Bartsch, S., Zoelzer, V., Tschesche, H., Kessler, H.
Deposit date:1999-02-23
Release date:1999-05-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
J.Mol.Biol., 289, 1999
1BQQ
  • Download 1bqq
  • View 1bqq
Molmil generated image of 1bqq
CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX
Descriptor:MEMBRANE-TYPE MATRIX METALLOPROTEINASE, METALLOPROTEINASE INHIBITOR 2, CALCIUM ION, ...
Authors:Fernandez-Catalan, C., Bode, W., Huber, R., Turk, D., Calvete, J.J., Lichte, A., Tschesche, H., Maskos, K.
Deposit date:1998-08-18
Release date:1999-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
EMBO J., 17, 1998
1BUV
  • Download 1buv
  • View 1buv
Molmil generated image of 1buv
CRYSTAL STRUCTURE OF THE MT1-MMP-TIMP-2 COMPLEX
Descriptor:PROTEIN (MEMBRANE-TYPE MATRIX METALLOPROTEINASE (CDMT1-MMP)), PROTEIN (METALLOPROTEINASE INHIBITOR (TIMP-2)), CALCIUM ION, ...
Authors:Fernandez-Catalan, C., Bode, W., Huber, R., Turk, D., Calvete, J.J., Lichte, A., Tschesche, H., Maskos, K.
Deposit date:1998-09-07
Release date:1999-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
EMBO J., 17, 1998
1JK3
  • Download 1jk3
  • View 1jk3
Molmil generated image of 1jk3
CRYSTAL STRUCTURE OF HUMAN MMP-12 (MACROPHAGE ELASTASE) AT TRUE ATOMIC RESOLUTION
Descriptor:MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ...
Authors:Lang, R., Kocourek, A., Braun, M., Tschesche, H., Huber, R., Bode, W., Maskos, K.
Deposit date:2001-07-11
Release date:2001-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
J.Mol.Biol., 312, 2001
2E2D
  • Download 2e2d
  • View 2e2d
Molmil generated image of 2e2d
FLEXIBILITY AND VARIABILITY OF TIMP BINDING: X-RAY STRUCTURE OF THE COMPLEX BETWEEN COLLAGENASE-3/MMP-13 AND TIMP-2
Descriptor:Matrix metallopeptidase 13, Metalloproteinase inhibitor 2, ZINC ION, ...
Authors:Maskos, K., Lang, R., Tschesche, H., Bode, W.
Deposit date:2006-11-11
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flexibility and Variability of TIMP Binding: X-ray Structure of the Complex Between Collagenase-3/MMP-13 and TIMP-2
J.Mol.Biol., 366, 2007
1MMB
  • Download 1mmb
  • View 1mmb
Molmil generated image of 1mmb
COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8
Descriptor:MATRIX METALLOPROTEINASE-8, CALCIUM ION, ZINC ION, ...
Authors:Bode, W., Grams, F.
Deposit date:1995-08-23
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Biochemistry, 34, 1995
1IAG
  • Download 1iag
  • View 1iag
Molmil generated image of 1iag
FIRST STRUCTURE OF A SNAKE VENOM METALLOPROTEINASE: A PROTOTYPE FOR MATRIX METALLOPROTEINASES(SLASH)COLLAGENASES
Descriptor:ADAMALYSIN II, ZINC ION, CALCIUM ION, ...
Authors:Gomis-Rueth, F.-X., Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.
EMBO J., 12, 1993
1KBC
  • Download 1kbc
  • View 1kbc
Molmil generated image of 1kbc
PROCARBOXYPEPTIDASE TERNARY COMPLEX
Descriptor:NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ...
Authors:Betz, M., Gomis-Rueth, F.X., Bode, W.
Deposit date:1997-04-29
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
Eur.J.Biochem., 247, 1997
4TPI
  • Download 4tpi
  • View 4tpi
Molmil generated image of 4tpi
THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor:TRYPSINOGEN, BOVINE PANCREATIC TRYPSIN INHIBITOR, VALINE, ...
Authors:Bode, W., Walter, J.
Deposit date:1985-06-11
Release date:1985-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
Eur.J.Biochem., 144, 1984
1OS2
  • Download 1os2
  • View 1os2
Molmil generated image of 1os2
TERNARY ENZYME-PRODUCT-INHIBITOR COMPLEXES OF HUMAN MMP12
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Mangani, S., Terni, B.
Deposit date:2003-03-18
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:X-ray Structures of Binary and Ternary Enzyme-Product-Inhibitor Complexes of Matrix Metalloproteinases
Angew.Chem.Int.Ed.Engl., 42, 2003
1OS9
  • Download 1os9
  • View 1os9
Molmil generated image of 1os9
BINARY ENZYME-PRODUCT COMPLEXES OF HUMAN MMP12
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION
Authors:Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Mangani, S., Terni, B.
Deposit date:2003-03-19
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray Structures of Binary and Ternary Enzyme-Product-Inhibitor Complexes of Matrix Metalloproteinases
Angew.Chem.Int.Ed.Engl., 42, 2003
1RMZ
  • Download 1rmz
  • View 1rmz
Molmil generated image of 1rmz
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH THE INHIBITOR NNGH AT 1.3 A RESOLUTION
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Mangani, S., Terni, B.
Deposit date:2003-11-28
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Conformational variability of matrix metalloproteinases: beyond a single 3D structure.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Y93
  • Download 1y93
  • View 1y93
Molmil generated image of 1y93
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MMP12 COMPLEXED WITH ACETOHYDROXAMIC ACID AT ATOMIC RESOLUTION
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Bertini, I., Calderone, V., Cosenza, M., Fragai, M., Lee, Y.-M., Luchinat, C., Mangani, S., Terni, B., Turano, P.
Deposit date:2004-12-14
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Conformational variability of matrix metalloproteinases: Beyond a single 3D structure
Proc.Natl.Acad.Sci.Usa, 102, 2005