1JH1
Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor
Summary for 1JH1
Entry DOI | 10.2210/pdb1jh1/pdb |
Descriptor | Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | collagenase, inhibitor, thiadiazine, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18102.88 |
Authors | Schroder, J.,Henke, A.,Wenzel, H.,Brandstetter, H.,Stammler, H.G.,Stammler, A.,Pfeiffer, W.D.,Tschesche, H. (deposition date: 2001-06-27, release date: 2001-12-27, Last modification date: 2024-04-03) |
Primary citation | Schroder, J.,Henke, A.,Wenzel, H.,Brandstetter, H.,Stammler, H.G.,Stammler, A.,Pfeiffer, W.D.,Tschesche, H. Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J.Med.Chem., 44:3231-3243, 2001 Cited by PubMed: 11563922DOI: 10.1021/jm010887p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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