Author results

1XAT
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STRUCTURE OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:XENOBIOTIC ACETYLTRANSFERASE
Authors:Beaman, T.W., Sugantino, M., Roderick, S.L.
Deposit date:1998-03-11
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa.
Biochemistry, 37, 1998
2XAT
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COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A
Descriptor:XENOBIOTIC ACETYLTRANSFERASE, CHLORAMPHENICOL, DESULFO-COENZYME A
Authors:Beaman, T.W., Sugantino, M., Roderick, S.L.
Deposit date:1998-03-11
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa.
Biochemistry, 37, 1998
1HV9
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STRUCTURE OF E. COLI GLMU: ANALYSIS OF PYROPHOSPHORYLASE AND ACETYLTRANSFERASE ACTIVE SITES
Descriptor:UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, COBALT (II) ION, COENZYME A, ...
Authors:Olsen, L.R., Roderick, S.L.
Deposit date:2001-01-08
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites.
Biochemistry, 40, 2001
2FN9
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THERMOTOGA MARITIMA RIBOSE BINDING PROTEIN UNLIGANDED FORM
Descriptor:ribose ABC transporter, periplasmic ribose-binding protein
Authors:Cuneo, M.J., Changela, A., Tian, Y., Beese, L.S., Hellinga, H.W.
Deposit date:2006-01-10
Release date:2007-01-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Ligand-induced conformational changes in a thermophilic ribose-binding protein.
Bmc Struct.Biol., 8, 2008
2GX6
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RATIONAL STABILIZATION OF E. COLI RIBOSE BINDING PROTEIN
Descriptor:D-ribose-binding periplasmic protein, RIBOSE(PYRANOSE FORM)
Authors:Cuneo, M.J., Hellinga, H.W.
Deposit date:2006-05-08
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Rational stabilization of E. coli ribose binding protein
To be Published
2H3H
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CRYSTAL STRUCTURE OF THE LIGANDED FORM OF THERMOTOGA MARITIMA GLUCOSE BINDING PROTEIN
Descriptor:Sugar ABC transporter, periplasmic sugar-binding protein, BETA-D-GLUCOSE
Authors:Changela, A., Tian, Y.
Deposit date:2006-05-22
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein.
Protein Sci., 16, 2007
2IOY
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CRYSTAL STRUCTURE OF THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN
Descriptor:Periplasmic sugar-binding protein, RIBOSE(PYRANOSE FORM)
Authors:Cuneo, M.J., Hellinga, H.W.
Deposit date:2006-10-11
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog.
Bmc Struct.Biol., 8, 2008
3O3I
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CRYSTAL STRUCTURE OF HUMAN HIWI1 PAZ DOMAIN (RESIDUES 277-399) IN COMPLEX WITH 14-MER RNA (12-BP + 2-NT OVERHANG) CONTAINING 2'-OH AT ITS 3'-END
Descriptor:Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*U)-3')
Authors:Tian, Y., Simanshu, D.K., Ma, J.-B., Patel, D.J.
Deposit date:2010-07-24
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3O6E
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CRYSTAL STRUCTURE OF HUMAN HIWI1 PAZ DOMAIN (RESIDUES 277-399) IN COMPLEX WITH 14-MER RNA (12-BP + 2-NT OVERHANG) CONTAINING 2'-OCH3 AT ITS 3'-END
Descriptor:Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*(OMU))-3')
Authors:Tian, Y., Simanshu, D.K., Ma, J.-B., Patel, D.J.
Deposit date:2010-07-28
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.904 Å)
Cite:Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3O7V
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CRYSTAL STRUCTURE OF HUMAN HIWI1 (V361M) PAZ DOMAIN (RESIDUES 277-399) IN COMPLEX WITH 14-MER RNA (12-BP + 2-NT OVERHANG) CONTAINING 2'-OCH3 AT ITS 3'-END
Descriptor:Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*(OMU))-3')
Authors:Tian, Y., Simanshu, D.K., Ma, J.-B., Patel, D.J.
Deposit date:2010-08-01
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3O7X
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CRYSTAL STRUCTURE OF HUMAN HILI PAZ DOMAIN
Descriptor:Piwi-like protein 2
Authors:Tian, Y., Simanshu, D.K., Ma, J.-B., Patel, D.J.
Deposit date:2010-08-01
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9248 Å)
Cite:Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q96
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B-RAF KINASE DOMAIN IN COMPLEX WITH A TETRAHYDRONAPHTHALENE INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Authors:Sintchak, M.D., Aertgeerts, K., Yano, J.
Deposit date:2011-01-07
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors.
J.Med.Chem., 54, 2011
3RIU
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CRYSTAL STRUCTURE OF DROSOPHILA HEXAMERIC C3PO FORMED BY TRUNCATED TRANSLIN AND TRAX
Descriptor:Translin, Translin associated factor X, isoform B
Authors:Tian, Y., Simanshu, D.K., Patel, D.J.
Deposit date:2011-04-14
Release date:2011-05-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Nat.Struct.Mol.Biol., 18, 2011
2LJ2
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INTEGRAL MEMBRANE CORE DOMAIN OF THE MERCURY TRANSPORTER MERF IN LIPID BILAYER MEMBRANES
Descriptor:MerF
Authors:Das, B.B., Nothnagel, H.J., Lu, G.J., Son, W., Park, S., Tian, Y.B., Marassi, F.M., Opella, S.J.
Deposit date:2011-09-03
Release date:2012-01-18
Last modified:2012-02-15
Method:SOLID-STATE NMR
Cite:Structure determination of a membrane protein in proteoliposomes.
J.Am.Chem.Soc., 134, 2012
2LK9
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STRUCTURE OF BST-2/TETHERIN TRANSMEMBRANE DOMAIN
Descriptor:Bone marrow stromal antigen 2
Authors:Skasko, M., Wang, Y., Tian, Y., Tokarev, A., Munguia, J., Ruiz, A., Stephens, E., Opella, S., Guatelli, J.
Deposit date:2011-10-07
Release date:2011-11-09
Last modified:2012-01-18
Method:SOLUTION NMR
Cite:HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions.
J.Biol.Chem., 287, 2012
2LNL
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STRUCTURE OF HUMAN CXCR1 IN PHOSPHOLIPID BILAYERS
Descriptor:C-X-C chemokine receptor type 1
Authors:Park, S., Das, B.B., Casagrande, F., Nothnagel, H., Chu, M., Kiefer, H., Maier, K., De Angelis, A., Marassi, F.M., Opella, S.J.
Deposit date:2011-12-31
Release date:2012-10-17
Last modified:2016-04-27
Method:SOLID-STATE NMR
Cite:Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
Nature, 491, 2012
4DDP
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CRYSTAL STRUCTURE OF BECLIN 1 EVOLUTIONARILY CONSERVED DOMAIN(ECD)
Descriptor:Beclin-1
Authors:Huang, W.J., Choi, W.Y., Wang, J.W., Shi, Y.G.
Deposit date:2012-01-19
Release date:2012-02-22
Method:X-RAY DIFFRACTION (1.547 Å)
Cite:Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Cell Res., 2012
4EO6
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HCV NS5B POLYMERASE INHIBITORS: TRI-SUBSTITUTED ACYLHYDRAZINES AS TERTIARY AMIDE BIOISOSTERES
Descriptor:RNA-directed RNA polymerase, 5-(3,3-dimethylbut-1-yn-1-yl)-3-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}thiophene-2-carboxylic acid
Authors:Appleby, T.C., Canales, E., Watkins, W.J.
Deposit date:2012-04-13
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.791 Å)
Cite:Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4EO8
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HCV NS5B POLYMERASE INHIBITORS: TRI-SUBSTITUTED ACYLHYDRAZINES AS TERTIARY AMIDE BIOISOSTERES
Descriptor:RNA-directed RNA polymerase, 5-(3,3-dimethylbut-1-yn-1-yl)-3-{2,2-dimethyl-1-[(trans-4-methylcyclohexyl)carbonyl]hydrazinyl}thiophene-2-carboxylic acid
Authors:Appleby, T.C., Canales, E., Watkins, W.J.
Deposit date:2012-04-13
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4F9E
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CYCLIC DI-GMP SENSING VIA THE INNATE IMMUNE SIGNALING PROTEIN STING
Descriptor:Transmembrane protein 173
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
4F9G
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CRYSTAL STRUCTURE OF STING COMPLEX WITH CYCLIC DI-GMP.
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
2M67
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FULL-LENGTH MERCURY TRANSPORTER PROTEIN MERF IN LIPID BILAYER MEMBRANES
Descriptor:MerF
Authors:Lu, G.J., Tian, Y., Vora, N., Marassi, F.M., Opella, S.J.
Deposit date:2013-03-27
Release date:2013-07-03
Last modified:2013-07-10
Method:SOLID-STATE NMR
Cite:The Structure of the Mercury Transporter MerF in Phospholipid Bilayers: A Large Conformational Rearrangement Results from N-Terminal Truncation.
J.Am.Chem.Soc., 135, 2013
4L5Q
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CRYSTAL STRUCTURE OF P202 HIN1
Descriptor:Interferon-activable protein 202
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5R
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CRYSTAL STRUCTURE OF P202 HIN1 IN COMPLEX WITH 20-MER DSDNA
Descriptor:Interferon-activable protein 202, 20-mer DNA, SODIUM ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.873 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5S
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P202 HIN1 IN COMPLEX WITH 12-MER DSDNA
Descriptor:Interferon-activable protein 202, 12-mer DNA, SULFATE ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-08-14
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013