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1S1D
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STRUCTURE AND PROTEIN DESIGN OF HUMAN APYRASE
Descriptor:apyrase, CALCIUM ION, ACETATE ION, ...
Authors:Dai, J., Liu, J., Deng, Y., Smith, T.M., Lu, M.
Deposit date:2004-01-06
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and protein design of a human platelet function inhibitor.
Cell(Cambridge,Mass.), 116, 2004
6CCK
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH (R)-3-(3-CHLOROPHENYL)-3-((5-METHYL-7-OXO-4,7-DIHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)AMINO)PROPANENITRILE
Descriptor:Phosphopantetheine adenylyltransferase, (3R)-3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-6,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6QSW
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COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR N-(2-BROMO-4-METHYLNAPHTHALEN-1-YL)-4,5-DIHYDRO-1H-IMIDAZOL-2-AMINE.
Descriptor:Complement factor B, SULFATE ION, ~{N}-(2-bromanyl-4-methyl-naphthalen-1-yl)-4,5-dihydro-1~{H}-imidazol-2-amine
Authors:Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.
Deposit date:2019-02-22
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Complement factor B protease domain in complex with the reversible inhibitor PKF
To Be Published
1S18
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STRUCTURE AND PROTEIN DESIGN OF HUMAN APYRASE
Descriptor:apyrase, CALCIUM ION, ACETATE ION, ...
Authors:Dai, J., Liu, J., Deng, Y., Smith, T.M., Lu, M.
Deposit date:2004-01-05
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and protein design of a human platelet function inhibitor.
Cell(Cambridge,Mass.), 116, 2004
6RAV
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COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID
Descriptor:Complement factor B, SULFATE ION, 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, ...
Authors:Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.
Deposit date:2019-04-08
Release date:2019-04-17
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
To be published
6CCL
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH 1-BENZYL-1H-IMIDAZO[4,5-B]PYRIDINE
Descriptor:Phosphopantetheine adenylyltransferase, 1-benzyl-1H-imidazo[4,5-b]pyridine, SULFATE ION, ...
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6QSX
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COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR ((2S,4S)-1-((5,7-DIMETHYL-1H-INDOL-4-YL)METHYL)-4-METHOXYPIPERIDIN-2-YL)METHANOL.
Descriptor:Complement factor B, SULFATE ION, [(2~{S},4~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]-4-methoxy-piperidin-2-yl]methanol, ...
Authors:Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.
Deposit date:2019-02-22
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Complement factor B protease domain in complex with the reversible inhibitor NVP-LNP023
To Be Published
6CCM
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH 2-((3-BROMOBENZYL)AMINO)-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(4H)-ONE
Descriptor:Phosphopantetheine adenylyltransferase, 2-{[(3-bromophenyl)methyl]amino}-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(6H)-one, SULFATE ION
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
1WAP
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TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN
Descriptor:TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN
Authors:Antson, A.A., Dodson, E.J., Gollnick, P.
Deposit date:1995-02-03
Release date:1995-06-03
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of trp RNA-binding attenuation protein.
Nature, 374, 1995
6CCO
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH 3-((1S,2S)-2-(4-HYDROXY-1H-BENZO[D]IMIDAZOL-2-YL)CYCLOPENTYL)BENZOIC ACID
Descriptor:Phosphopantetheine adenylyltransferase, 3-[(1S,2S)-2-(7-hydroxy-1H-benzimidazol-2-yl)cyclopentyl]benzoic acid, SULFATE ION
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6CCN
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH (R)-2,4-DIHYDROXY-N-(2-(4-HYDROXY-1H-BENZO[D]IMIDAZOL-2-YL)ETHYL)-3,3-DIMETHYLBUTANAMIDE
Descriptor:Phosphopantetheine adenylyltransferase, (2R)-2,4-dihydroxy-N-[2-(7-hydroxy-1H-benzimidazol-2-yl)ethyl]-3,3-dimethylbutanamide, SULFATE ION
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6CCQ
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH 2-(3-CHLOROPHENETHYL)-1H-BENZO[D]IMIDAZOL-4-OL
Descriptor:Phosphopantetheine adenylyltransferase, 2-[2-(3-chlorophenyl)ethyl]-1H-benzimidazol-7-ol, SULFATE ION
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6CCS
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CRYSTAL STRUCTURE OF E.COLI PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE (PPAT/COAD) IN COMPLEX WITH 2-(TRIFLUOROMETHYL)-1H-BENZO[D]IMIDAZOL-4-OL
Descriptor:Phosphopantetheine adenylyltransferase, 2-(trifluoromethyl)-1H-benzimidazol-7-ol, SULFATE ION
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6OAU
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APO STRUCTURE OF WT LIPOPROTEIN LIPASE IN COMPLEX WITH GPIHBP1 MUTANT N78D N82D PRODUCED IN GNTI-DEFICIENT HEK293-F CELLS
Descriptor:Lipoprotein lipase, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Arora, R., Horton, P.A., Benson, T.E., Romanowski, M.J.
Deposit date:2019-03-18
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure of lipoprotein lipase in complex with GPIHBP1.
Proc.Natl.Acad.Sci.USA, 2019
1QAW
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REGULATORY FEATURES OF THE TRP OPERON AND THE CRYSTAL STRUCTURE OF THE TRP RNA-BINDING ATTENUATION PROTEIN FROM BACILLUS STEAROTHERMOPHILUS.
Descriptor:TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN
Authors:Chen, X.-P., Antson, A.A., Yang, M., Baumann, C., Dodson, E.J., Dodson, G.G., Gollnick, P.
Deposit date:1999-03-31
Release date:1999-04-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus.
J.Mol.Biol., 289, 1999
6OB0
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COMPOUND 2 BOUND STRUCTURE OF WT LIPOPROTEIN LIPASE IN COMPLEX WITH GPIHBP1 MUTANT N78D N82D PRODUCED IN HEK293-F CELLS
Descriptor:Lipoprotein lipase, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Arora, R., Horton, P.A., Benson, T.E., Romanowski, M.J.
Deposit date:2019-03-19
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structure of lipoprotein lipase in complex with GPIHBP1.
Proc.Natl.Acad.Sci.USA, 2019
6OAZ
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APO STRUCTURE OF WT LIPOPROTEIN LIPASE IN COMPLEX WITH GPIHBP1 MUTANT N78D N82D PRODUCED IN HEK293-F CELLS
Descriptor:Lipoprotein lipase, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Arora, R., Horton, P.A., Benson, T.E., Romanowski, M.J.
Deposit date:2019-03-19
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structure of lipoprotein lipase in complex with GPIHBP1.
Proc.Natl.Acad.Sci.USA, 2019