6QSX

Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.

This is a large structure.

Summary for 6QSX

DescriptorComplement factor B, SULFATE ION, [(2~{S},4~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]-4-methoxy-piperidin-2-yl]methanol, ... (5 entities in total)
Functional Keywordscomplement, immune, inhibitor, c3 convertase, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight67319.85
Authors
Primary citation
Adams, C.M.,Sellner, H.,Ehara, T.,Mac Sweeney, A.,Crowley, M.,Anderson, K.,Karki, R.,Mainolfi, N.,Valeur, E.,Sirockin, F.,Gerhartz, B.,Erbel, P.,Hughes, N.,Smith, T.M.,Cumin, F.,Argikar, U.,Mogi, M.,Sedrani, R.,Wiesmann, C.,Jaffee, B.,Maibaum, J.,Flohr, S.,Harrison, R.,Eder, J.,Schubart, A.,Liao, S.-M.,Littlewood-Evans, A.,Sarret, S.,Wiekzorek, G.,Perrot, L.,Dubost, V.,Flandre, T.,Zhang, Y.,Haraldsson, B.
Complement factor B protease domain in complex with the reversible inhibitor NVP-LNP023
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.77 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22720 1.6% 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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