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6CCL

Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with 1-benzyl-1H-imidazo[4,5-b]pyridine

Summary for 6CCL
Entry DOI10.2210/pdb6ccl/pdb
DescriptorPhosphopantetheine adenylyltransferase, 1-benzyl-1H-imidazo[4,5-b]pyridine, SULFATE ION, ... (5 entities in total)
Functional Keywordsppat coad fbdd phosphopantetheine adenylyltransferase gram-negative antibacterial antibiotic, transferase, transferase-antibiotic complex, transferase/antibiotic
Biological sourceEscherichia coli (strain K12)
Cellular locationCytoplasm : P0A6I6
Total number of polymer chains2
Total formula weight37220.70
Authors
Mamo, M.,Appleton, B.A. (deposition date: 2018-02-07, release date: 2018-03-14, Last modification date: 2024-03-13)
Primary citationMoreau, R.J.,Skepper, C.K.,Appleton, B.A.,Blechschmidt, A.,Balibar, C.J.,Benton, B.M.,Drumm, J.E.,Feng, B.Y.,Geng, M.,Li, C.,Lindvall, M.K.,Lingel, A.,Lu, Y.,Mamo, M.,Mergo, W.,Polyakov, V.,Smith, T.M.,Takeoka, K.,Uehara, K.,Wang, L.,Wei, J.R.,Weiss, A.H.,Xie, L.,Xu, W.,Zhang, Q.,de Vicente, J.
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61:3309-3324, 2018
Cited by
PubMed: 29498517
DOI: 10.1021/acs.jmedchem.7b01691
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

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