Author results

4KPY
  • Download 4kpy
  • View 4kpy
Molmil generated image of 4kpy
DNA BINDING PROTEIN AND DNA COMPLEX STRUCTURE
分子名称:Uncharacterized protein, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-05-14
公開日2014-01-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N41
  • Download 4n41
  • View 4n41
Molmil generated image of 4n41
STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 15-MER TARGET DNA
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N47
  • Download 4n47
  • View 4n47
Molmil generated image of 4n47
STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 12-MER TARGET DNA
分子名称:Argonaute, 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.823 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N76
  • Download 4n76
  • View 4n76
Molmil generated image of 4n76
STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND CLEAVED TARGET DNA WITH MN2+
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-15
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCA
  • Download 4nca
  • View 4nca
Molmil generated image of 4nca
STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA 19-MER AND TARGET DNA IN THE PRESENCE OF MN2+
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-24
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.489 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCB
  • Download 4ncb
  • View 4ncb
Molmil generated image of 4ncb
STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 19-MER TARGET DNA WITH MG2+
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-24
公開日2014-01-15
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2.189 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
5XOU
  • Download 5xou
  • View 5xou
Molmil generated image of 5xou
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 7T8 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XOW
  • Download 5xow
  • View 5xow
Molmil generated image of 5xow
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'A7' ON THE TARGET STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*(TD)P*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*AP*CP*CP*UP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XP8
  • Download 5xp8
  • View 5xp8
Molmil generated image of 5xp8
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 4A5 ON THE GUIDE STRAND
分子名称:TtAgo, DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPA
  • Download 5xpa
  • View 5xpa
Molmil generated image of 5xpa
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 9'U10' ON THE TARGET STRAND
分子名称:Uncharacterized protein Ago, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*AP*UP*AP*CP*AP*AP*CP*CP*GP*UP*UP*CP*UP*AP*CP*UP*CP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPG
  • Download 5xpg
  • View 5xpg
Molmil generated image of 5xpg
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'U7' ON THE TARGET STRAND
分子名称:Uncharacterized protein, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*A P*GP*T)-3', 5'-R(*UP*AP*U*AP*CP*AP*AP*CP*CP*UP*AP*CP*AP*UP*AP*CP*CP*UP*CP* G)-3', ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-02
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XQ2
  • Download 5xq2
  • View 5xq2
Molmil generated image of 5xq2
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 5A6 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D., Wang, Y.
登録日2017-06-06
公開日2017-10-04
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
3NCU
  • Download 3ncu
  • View 3ncu
Molmil generated image of 3ncu
STRUCTURAL AND FUNCTIONAL INSIGHTS INTO PATTERN RECOGNITION BY THE INNATE IMMUNE RECEPTOR RIG-I
分子名称:RIG-I, 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3', ZINC ION
著者Sheng, G., Li, H.
登録日2010-06-05
公開日2010-06-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.
Nat.Struct.Mol.Biol., 17, 2010
4U7U
  • Download 4u7u
  • View 4u7u
Molmil generated image of 4u7u
CRYSTAL STRUCTURE OF RNA-GUIDED IMMUNE CASCADE COMPLEX FROM E.COLI
分子名称:CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasE, ...
著者Zhao, H., Sheng, G., Wang, J., Wang, M., Bunkoczi, G., Gong, W., Wei, Z., Wang, Y.
登録日2014-07-31
公開日2014-08-27
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
Nature, 515, 2014
3DLB
  • Download 3dlb
  • View 3dlb
Molmil generated image of 3dlb
CRYSTAL STRUCTURE OF THE GUIDE-STRAND-CONTAINING ARGONAUTE PROTEIN SILENCING COMPLEX
分子名称:argonaute, DNA (5'-D(*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DA)-3')
著者Wang, Y., Sheng, G., Patel, D.J.
登録日2008-06-26
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
3DLH
  • Download 3dlh
  • View 3dlh
Molmil generated image of 3dlh
CRYSTAL STRUCTURE OF THE GUIDE-STRAND-CONTAINING ARGONAUTE PROTEIN SILENCING COMPLEX
分子名称:Argonaute, DNA (5'-D(DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DAP*DTP*DAP*DGP*DT)-3'), MAGNESIUM ION, ...
著者Wang, Y., Sheng, G., Patel, D.J.
登録日2008-06-27
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
3F73
  • Download 3f73
  • View 3f73
Molmil generated image of 3f73
ALIGNMENT OF GUIDE-TARGET SEED DUPLEX WITHIN AN ARGONAUTE SILENCING COMPLEX
分子名称:ARGONAUTE, DNA (5'-D(P*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DA*DTP*DAP*DGP*DT)-3'), RNA (5'-R(*UP*AP*UP*AP*CP*AP*A*CP*UP*CP*AP*CP*UP*AP*CP*CP*UP*CP*GP*U)-3'), ...
著者Wang, Y., Li, H., Sheng, G., Juranek, S., Tuschl, T., Patel, D.J.
登録日2008-11-07
公開日2008-12-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.
Nature, 456, 2008
3HJF
  • Download 3hjf
  • View 3hjf
Molmil generated image of 3hjf
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE E546 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 15-NT RNA TARGET STRAND
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-05-21
公開日2009-10-06
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.056 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HK2
  • Download 3hk2
  • View 3hk2
Molmil generated image of 3hk2
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N478 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-05-22
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HM9
  • Download 3hm9
  • View 3hm9
Molmil generated image of 3hm9
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-05-28
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HO1
  • Download 3ho1
  • View 3ho1
Molmil generated image of 3ho1
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N546 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 12-NT RNA TARGET STRAND
分子名称:argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*T*AP*GP*T)-3', 5'-R(P*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-06-01
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HVR
  • Download 3hvr
  • View 3hvr
Molmil generated image of 3hvr
CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND WITH TWO MG2+ AT THE CLEAVAGE SITE
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-06-16
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.211 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HXM
  • Download 3hxm
  • View 3hxm
Molmil generated image of 3hxm
STRUCTURE OF AN ARGONAUTE COMPLEXED WITH GUIDE DNA AND TARGET RNA DUPLEX CONTAINING TWO MISMATCHES.
分子名称:Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*UP*CP*AP*CP*UP*AP*CP*CP*UP*CP*GP*U)-3'), ...
著者Wang, Y., Li, H., Sheng, G., Patel, D.J.
登録日2009-06-21
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
4N77
  • Download 4n77
  • View 4n77
Molmil generated image of 4n77
CRYSTAL STRUCTURE OF CAS PROTEIN
分子名称:Uncharacterized protein
著者Tian, W., Sheng, G., Zhao, H., Wang, J., Wang, Y.
登録日2013-10-15
公開日2014-10-15
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal strucute studies of CasD
To be Published
5DLJ
  • Download 5dlj
  • View 5dlj
Molmil generated image of 5dlj
CRYSTAL STRUCTURE OF CAS-DNA-N1 COMPLEX
分子名称:CRISPR-associated endonuclease Cas1, 39-mer DNA N1-F, 39-mer DNA N1-R, ...
著者Wang, J., Li, J., Zhao, H., Sheng, G., Wang, M., Yin, M., Wang, Y.
登録日2015-09-05
公開日2015-11-11
最終更新日2015-11-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems.
Cell, 163, 2015
<12>