Author results

4FVQ
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CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN (MG-ATP-BOUND FORM)
Descriptor:Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
2FAT
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AN ANTI-UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (UPAR) ANTIBODY: CRYSTAL STRUCTURE AND BINDING EPITOPE
Descriptor:FAB ATN-615, light chain, heavy chain
Authors:Li, Y., Parry, G., Shi, X., Chen, L., Callahan, J.A., Mazar, A.P., Huang, M.
Deposit date:2005-12-07
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope
J.Mol.Biol., 365, 2007
2FD6
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STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR IN COMPLEX WITH UROKINASE RECEPTOR AND AN ANTI-UPAR ANTIBODY AT 1.9 A
Descriptor:Urokinase-type plasminogen activator, L chain of Fab of ATN-615 anti-uPAR antibody, H chain of Fab of ATN-615 anti-uPAR antibody, ...
Authors:Huang, M., Huai, Q., Li, Y.
Deposit date:2005-12-13
Release date:2006-02-21
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311, 2006
2I9A
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CRYSTAL STRUCTURE OF THE FREE AMINOTERMINAL FRAGMENT OF UROKINASE TYPE PLASMINOGEN ACTIVATOR (ATF)
Descriptor:Urokinase-type plasminogen activator, PHOSPHATE ION
Authors:Lubkowski, J., Barinka, C.
Deposit date:2006-09-05
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
4FVR
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CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN MUTANT V617F (MG-ATP-BOUND FORM)
Descriptor:Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
5IIW
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CORKSCREW ASSEMBLY OF SOD1 RESIDUES 28-38 WITHOUT POTASSIUM IODIDE
Descriptor:Superoxide dismutase [Cu-Zn]
Authors:Sangwan, S., Zhao, A., Sawaya, M.R., Eisenberg, D.
Deposit date:2016-03-01
Release date:2017-06-28
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4FVP
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CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN (APO FORM)
Descriptor:Tyrosine-protein kinase JAK2, GLYCEROL
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
5DLI
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CORKSCREW ASSEMBLY OF SOD1 RESIDUES 28-38
Descriptor:Superoxide dismutase [Cu-Zn], GLYCEROL, IODIDE ION
Authors:Sangwan, S., Zhao, A., Sawaya, M.R., Eisenberg, D.
Deposit date:2015-09-05
Release date:2016-09-14
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3VW7
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CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM
Descriptor:Proteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate, ...
Authors:Zhang, C., Srinivasan, Y., Arlow, D.H., Fung, J.J., Palmer, D., Zheng, Y., Green, H.F., Pandey, A., Dror, R.O., Shaw, D.E., Weis, W.I., Coughlin, S.R., Kobilka, B.K.
Deposit date:2012-08-07
Release date:2012-12-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High-resolution crystal structure of human protease-activated receptor 1
Nature, 492, 2012
3G6G
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EQUALLY POTENT INHIBITION OF C-SRC AND ABL BY COMPOUNDS THAT RECOGNIZE INACTIVE KINASE CONFORMATIONS
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, GLYCEROL
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3G6H
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SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
4HK0
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UCA FAB (UNBOUND) FROM CH65-CH67 LINEAGE
Descriptor:UCA heavy chain, UCA light chain
Authors:Schmidt, A.G., Harrison, S.C.
Deposit date:2012-10-14
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
3BT2
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
4HKX
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INFLUENZA HEMAGGLUTININ IN COMPLEX WITH CH67 FAB
Descriptor:Hemagglutinin HA1, CH67 heavy chain, CH67 light chain, ...
Authors:Schmidt, A.G., Harrison, S.C.
Deposit date:2012-10-15
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
4U97
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CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER
Descriptor:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R., Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
3KEX
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CRYSTAL STRUCTURE OF THE CATALYTICALLY INACTIVE KINASE DOMAIN OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3)
Descriptor:Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
2I9B
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CRYSTAL STRUCTURE OF ATF-UROKINASE RECEPTOR COMPLEX
Descriptor:Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lubkowski, J., Barinka, C.
Deposit date:2006-09-05
Release date:2007-01-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
3BT1
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, Urokinase plasminogen activator surface receptor, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
4U9A
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SULPHUR ANOMALOUS CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER
Descriptor:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R., Liu, Q., Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
4YGA
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CDPK1, FROM TOXOPLASMA GONDII, BOUND TO INHIBITORY VHH-1B7
Descriptor:Calmodulin-domain protein kinase 1, VHH-1B7, CALCIUM ION
Authors:Knockenhauer, K.E., Schwartz, T.U.
Deposit date:2015-02-26
Release date:2015-08-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Allosteric activation of apicomplexan calcium-dependent protein kinases.
Proc.Natl.Acad.Sci.USA, 112, 2015
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
4RIY
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-E909G MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4HK3
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I2 FAB (UNBOUND) FROM CH65-CH67 LINEAGE
Descriptor:I2 heavy chain, I2 light chain
Authors:Schmidt, A.G., Harrison, S.C.
Deposit date:2012-10-14
Release date:2012-11-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
4RIW
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIX
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CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
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