3KEX
Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)
Summary for 3KEX
Entry DOI | 10.2210/pdb3kex/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | kinase domain, inactive kinase, her3, erbb3, atp-binding, cell membrane, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860 |
Total number of polymer chains | 2 |
Total formula weight | 73959.42 |
Authors | Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J. (deposition date: 2009-10-26, release date: 2009-12-22, Last modification date: 2024-04-03) |
Primary citation | Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J. Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc.Natl.Acad.Sci.USA, 106:21608-21613, 2009 Cited by PubMed: 20007378DOI: 10.1073/pnas.0912101106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.797 Å) |
Structure validation
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