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2IEG
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH 3,4-DIHYDRO-2-QUINOLONE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Birch, A.M., Kenny, P.W., Oikonomakos, N.G., Otterbein, L., Schofield, P., Whittamore, P.R.O., Whalley, D.P., Rowsell, S., Pauptit, R., Pannifer, A., Breed, J., Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2IEI
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CRYSTAL STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH 3,4-DIHYDRO-2-QUINOLONE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Birch, A.M., Kenny, P.W., Oikonomakos, N.G., Otterbein, L., Schofield, P., Whittamore, P.R.O., Whalley, D.P., Rowsell, S., Pauptit, R., Pannifer, A., Breed, J., Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2GJ4
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STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH LIGAND
Descriptor:Glycogen phosphorylase, muscle form, SULFATE ION, ...
Authors:Otterbein, L.R., Pannifer, A.D., Tucker, J., Breed, J., Oikonomakos, N.G., Rowsell, S., Pauptit, R.A., Claire, M.
Deposit date:2006-03-30
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16, 2006
2GM9
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STRUCTURE OF RABBIT MUSCLE GLYCOGEN PHOSPHORYLASE IN COMPLEX WITH THIENOPYRROLE
Descriptor:Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ...
Authors:Otterbein, L.R., Pannifer, A.D., Tucker, J., Breed, J., Oikonomakos, N.G., Minshull, C., Rowsell, S., Pauptit, R.A.
Deposit date:2006-04-06
Release date:2007-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16, 2006
3UPA
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A GENERAL STRATEGY FOR THE GENERATION OF HUMAN ANTIBODY VARIABLE DOMAINS WITH INCREASED AGGREGATION RESISTANCE
Descriptor:kappa light chain variable domain
Authors:Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D.
Deposit date:2011-11-17
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
3UPC
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A GENERAL STRATEGY FOR THE GENERATION OF HUMAN ANTIBODY VARIABLE DOMAINS WITH INCREASED AGGREGATION RESISTANCE
Descriptor:heavy chain variable domain, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ...
Authors:Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D.
Deposit date:2011-11-17
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
4HFR
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HUMAN 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 IN COMPLEX WITH AN ORALLY BIOAVAILABLE ACIDIC INHIBITOR AZD4017.
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid
Authors:Ogg, D.J., Gerhardt, S., Hargreaves, D.
Deposit date:2012-10-05
Release date:2012-10-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
J.Med.Chem., 55, 2012
4N1C
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STRUCTURAL EVIDENCE FOR ANTIGEN RECEPTOR EVOLUTION
Descriptor:immunoglobulin variable light chain domain, Lysozyme C
Authors:Langley, D.B., Rouet, R., Roome, B., Stock, D., Christ, D.
Deposit date:2013-10-03
Release date:2014-10-29
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural reconstruction of protein ancestry.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4N1E
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STRUCTURAL EVIDENCE FOR ANTIGEN RECEPTOR EVOLUTION
Descriptor:immunoglobulin variable light chain domain, Lysozyme C
Authors:Langley, D.B., Rouet, R., Stock, D., Christ, D.
Deposit date:2013-10-04
Release date:2014-10-29
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural reconstruction of protein ancestry.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5J7C
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A PICOMOLAR AFFINITY FN3 DOMAIN IN COMPLEX WITH HEN EGG-WHITE LYSOZYME
Descriptor:Lysozyme C, FNfn10-anti-lysozyme (DE0.4.1)
Authors:Porebski, B.T., Drinkwater, N., McGowan, S., Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016
5J7K
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LOOP GRAFTING ONTO A HIGHLY STABLE FN3 SCAFFOLD
Descriptor:FN3con-a-lys, ZINC ION
Authors:Porebski, B.T., Drinkwater, N., McGowan, S., Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016
5V8G
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PEKIN DUCK LYSOZYME ISOFORM I (DEL-I)
Descriptor:lysozyme isoform I, THIOCYANATE ION, CHLORIDE ION
Authors:Langley, D.B., Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5V92
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PEKIN DUCK EGG LYSOZYME ISOFORM III (DEL-III), ORTHORHOMBIC FORM
Descriptor:lysozyme isoform III, PHOSPHATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Langley, D.B., Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5V94
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PEKIN DUCK EGG LYSOZYME ISOFORM III (DEL-III), CUBIC FORM
Descriptor:lysozyme isoform III, PHOSPHATE ION, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Langley, D.B., Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5VAS
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PEKIN DUCK EGG LYSOZYME ISOFORM III (DEL-III), ORTHORHOMBIC FORM
Descriptor:Lysozyme, PHOSPHATE ION, GLYCEROL
Authors:Christie, M., Christ, D., Langley, D.B.
Deposit date:2017-03-27
Release date:2018-04-18
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5VJO
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COMPLEX BETWEEN HYHEL10 FAB FRAGMENT HEAVY CHAIN MUTANT I29F AND PEKIN DUCK EGG LYSOZYME ISOFORM I (DEL-I)
Descriptor:HyHEL10 heavy chain Fab fragment carrying I29F mutation., HyHEL10 light chain Fab fragment, lysozyme isoform I (DEL-I), ...
Authors:Langley, D.B., Christ, D.
Deposit date:2017-04-19
Release date:2018-04-11
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
5VJQ
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COMPLEX BETWEEN HYHEL10 FAB FRAGMENT HEAVY CHAIN MUTANT (I29F, S52T, Y53F) AND PEKIN DUCK EGG LYSOZYME ISOFORM I (DEL-I)
Descriptor:HyHEL10 heavy chain Fab fragment carrying three mutations; I29F, S52T, Y53F, ...
Authors:Langley, D.B., Christ, D.
Deposit date:2017-04-19
Release date:2018-04-11
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
6BFT
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STRUCTURE OF BEVACIZUMAB FAB MUTANT IN COMPLEX WITH VEGF
Descriptor:Avastin Light Chain Fab fragment mutant, Avastin Heavy Chain Fab fragment mutant, Vascular endothelial growth factor A, ...
Authors:Christie, M., Christ, D.
Deposit date:2017-10-27
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Stable human IgG antibody therapeutics with native framework structure
To Be Published
6BGT
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STRUCTURE OF TRASTUZUMAB FAB MUTANT IN COMPLEX WITH HER2 EXTRACELLULAR DOMAIN
Descriptor:Receptor tyrosine-protein kinase erbB-2, Herceptin light chain mutant, Herceptin heavy chain Fab fragment mutant, ...
Authors:Christie, M., Christ, D.
Deposit date:2017-10-29
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stable human IgG antibody therapeutics with native framework structure
To Be Published
6MH2
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STRUCTURE OF HERCEPTIN FAB WITHOUT ANTIGEN
Descriptor:Herceptin Fab arm light chain, Herceptin Fab arm heavy chain
Authors:Luthra, A., Langley, D.B., Christie, M., Christ, D.
Deposit date:2018-09-17
Release date:2019-05-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Antibody Bispecifics through Phage Display Selection.
Biochemistry, 58, 2019