2IEG

Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone

Summary for 2IEG

Related2IEI
DescriptorGlycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycogen phosphorylase, glypho, diabetes, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains2
Total molecular weight195854.43
Authors
Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.O.,Whalley, D.P.,Rowsell, S.,Pauptit, R.,Pannifer, A.,Breed, J.,Minshull, C. (deposition date: 2006-09-19, release date: 2006-12-26, Last modification date: 2011-07-13)
Primary citation
Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.,Whalley, D.P.
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17:394-399, 2007
PubMed: 17095214 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2006.10.037
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27280.3%4.9%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution