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2IEG

Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone

Summary for 2IEG
Entry DOI10.2210/pdb2ieg/pdb
Related2IEI
DescriptorGlycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycogen phosphorylase, glypho, diabetes, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains2
Total formula weight195854.43
Authors
Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.O.,Whalley, D.P.,Rowsell, S.,Pauptit, R.,Pannifer, A.,Breed, J.,Minshull, C. (deposition date: 2006-09-19, release date: 2006-12-26, Last modification date: 2011-07-13)
Primary citationBirch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.,Whalley, D.P.
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17:394-399, 2007
Cited by
PubMed: 17095214
DOI: 10.1016/j.bmcl.2006.10.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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